Takotsubo Cardiomyopathy ‘Clustering’: A Novel Observation Associated With an Unprecedented Flooding Event

Autor: Alice Pearlman, David Amos, Alex Elder, Harry C. Lowe, Ruth Arnold

Publikováno v: Heart, Lung and Circulation. 32:e36-e37

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e9ef5c907ad93644ea7c176fd37f9d4
https://doi.org/10.1016/j.hlc.2023.02.008

Epigenetic Regulator Genes Direct the Fate of Multipotent Progenitor Cell of Origin in Lineage Switched MLL-AF4 Leukaemia

Autor: Simon Bomken, James C. Mulloy, Peter Carey, Zoya Kingsbury, Josef Vormoor, Paul Milne, Christine J. Harrison, Helen Blair, Jennifer Becq, Lisa J. Russell, Peter N. Cockerill, Jean-Baptiste Cazier, Constanze Bonifer, Daniel Williamson, James M Allan, Paul Evans, Anetta Ptasinska, Sirintra Nakjang, Maria Rosaria Imperato, Elena Zerkalenkova, Rolf Marschalek, Michael J. Thirman, Shan Lin, Alex Smith, Natalia Miakova, Muzlifa Haniffa, Ricky Tirtakusuma, Simon Bailey, Salam A. Assi, Catherine Cargo, Pierre Cauchy, Y Shi, Hesta McNeill, Yulia Olshanskaya, Fotini Vogiatzi, Claus Meyer, Sarah E. Fordham, Alex Elder, Matthew Collin, Roderick Skinner, Venetia Bigley, Olaf Heidenreich, A Komkov, Cornelia Eckert, Deepali Pal, Denis M. Schewe, N Martinez-Soria, Oskar A. Haas

Publikováno v: SSRN Electronic Journal.

SummaryThe translocation MLL-AF4 defines a high-risk subtype of acute leukaemia which, uniquely amongst MLL translocations, is almost exclusively associated with a pro-B lymphoid phenotype. However, the ability to switch lineage at relapse allowed in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8147925f93c78a7360a68fde7683cdc4
https://doi.org/10.2139/ssrn.3432467

The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation

Autor: Natalia Martinez-Soria, Lynsey McKenzie, Julia Draper, Anetta Ptasinska, Hasan Issa, Sandeep Potluri, Helen J. Blair, Anna Pickin, Asmida Isa, Paulynn Suyin Chin, Ricky Tirtakusuma, Daniel Coleman, Sirintra Nakjang, Salam Assi, Victoria Forster, Mojgan Reza, Ed Law, Philip Berry, Dorothee Mueller, Cameron Osborne, Alex Elder, Simon N. Bomken, Deepali Pal, James M. Allan, Gareth J. Veal, Peter N. Cockerill, Christian Wichmann, Josef Vormoor, Georges Lacaud, Constanze Bonifer, Olaf Heidenreich

Publikováno v: Martinez-Soria, N, McKenzie, L, Draper, J, Ptasinska, A, Issa, H, Potluri, S, Blair, H J, Pickin, A, Isa, A, Chin, P S, Tirtakusuma, R, Coleman, D, Nakjang, S, Assi, S, Forster, V, Reza, M, Law, E, Berry, P, Mueller, D, Osborne, C, Elder, A, Bomken, S N, Pal, D, Allan, J M, Veal, G J, Cockerill, P N, Wichmann, C, Vormoor, J, Lacaud, G, Bonifer, C & Heidenreich, O 2018, ' The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation ', Cancer Cell, vol. 34, no. 4, pp. 705 . https://doi.org/10.1016/j.ccell.2018.08.015, https://doi.org/10.1016/j.ccell.2019.03.012
Cancer Cell
Martinez-Soria, N, McKenzie, L, Draper, J, Ptasinska, A, Issa, H, Potluri, S, Blair, H J, Pickin, A, Isa, A, Chin, P S, Tirtakusuma, R, Coleman, D, Nakjang, S, Assi, S, Forster, V, Reza, M, Law, E, Berry, P, Mueller, D, Elder, A, Bomken, S N, Pal, D, Allan, J M, Veal, G J, Cockerill, P N, Wichmann, C, Vormoor, J, Lacaud, G, Bonifer, C & Heidenreich, O 2018, ' The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation ', Cancer Cell, vol. 34, no. 4, pp. 626-642.e8 . https://doi.org/10.1016/j.ccell.2018.08.015

Summary Oncogenic transcription factors such as the leukemic fusion protein RUNX1/ETO, which drives t(8;21) acute myeloid leukemia (AML), constitute cancer-specific but highly challenging therapeutic targets. We used epigenomic profiling data for an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acacb6b896402d3704032615136e9045
https://research.manchester.ac.uk/en/publications/c8ac0ff2-d9af-420f-aa3b-957c35c55420

CD19: A multifunctional immunological target molecule and its implications for Blineage acute lymphoblastic leukemia

Autor: Steffen Koschmieder, Josef Vormoor, Olaf Heidenreich, Victoria J. Forster, Judith Weiland, Alex Elder

Publikováno v: Pediatric Blood & Cancer. 62:1144-1148

Over the last 20-30 years CD19 has gained attention as a potential target in the therapy of B-cell malignancies. In particular, targeting CD19 with the bispecific T-cell engager (BiTE) antibody Blinatumomab and T-cells modified by chimeric antigen re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a91c4e1f0d3ebe74d17eb6a4fc1cc42
https://doi.org/10.1002/pbc.25462

Differential expression of miR-17∼92 identifies BCL2 as a therapeutic target in BCR-ABL-positive B-lineage acute lymphoblastic leukemia

Autor: Anke Schröder, Andreas Pich, Helen J. Blair, Josef Vormoor, Olaf Heidenreich, Michaela Scherr, Oliver G. Ottmann, Alex Elder, Letizia Venturini, Karin Battmer, Denise Hilfiker-Kleiner, Melanie Ricke-Hoch, David Barzan, Matthias Eder, Arnold Ganser, Simon Bomken

Publikováno v: Leukemia

Despite advances in allogeneic stem cell transplantation, BCR-ABL-positive acute lymphoblastic leukaemia (ALL) remains a high-risk disease, necessitating the development of novel treatment strategies. As the known oncomir, miR-17~92, is regulated by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7348f34187d21282aab1fe16f4b3e33
http://europepmc.org/articles/PMC3948162