Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Alex E. Pozhitkov"'
Publikováno v:
Data in Brief, Vol 10, Iss C, Pp 30-32 (2017)
This article provides supporting data for the research article ‘Microbial Signatures of Oral Dysbiosis, Periodontitis and Edentulism Revealed by Gene Meter Methodology’ (M.C. Hunter, A.E. Pozhitkov, P.A. Noble, 2016) [1]. In that article, we dete
Externí odkaz:
https://doaj.org/article/bf5aacd3680d43edba9714a02339780d
Autor:
Aine Knott, Chengcheng Meng, Abigail E Case, Prafulla C. Gokhale, Alex E. Pozhitkov, Ruben D. Carrasco, Yin P Hung, Moshe Lapidot, James D. Griffin, Sunil Sharma, Martin Sattler, Raphael Bueno, Klaus Podar, David A. Frank, Sarah R. Walker, Srinivas Vinod Saladi, Swati Garg, Ellen Weisberg, Ravi Salgia, Prakash Kulkarni, Wei Ni
Publikováno v:
British Journal of Cancer
Background Malignant pleural mesothelioma (MPM) is a highly aggressive cancer with a dismal prognosis. There is increasing interest in targeting chromatin regulatory pathways in difficult-to-treat cancers. In preliminary studies, we found that KDM4A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b722840cbc4dafad4ce4ec4a441cbfc
http://europepmc.org/articles/PMC8368004
http://europepmc.org/articles/PMC8368004
Autor:
Alex E. Pozhitkov, Rafik Neme, Tomislav Domazet-Lošo, Brian G. Leroux, Shivani Soni, Diethard Tautz, Peter A. Noble
Publikováno v:
Open Biology, Vol 7, Iss 1 (2017)
In life, genetic and epigenetic networks precisely coordinate the expression of genes—but in death, it is not known if gene expression diminishes gradually or abruptly stops or if specific genes and pathways are involved. We studied this by identif
Externí odkaz:
https://doaj.org/article/cc6b5641f32446f9b557e92a49b58b1a
Autor:
Amrita Krishnan, Yafan Wang, Thomas P. Slavin, Xiewei Wu, Jinhui Wang, Kelly Peng, F. Lennie Wong, Stephen J. Forman, Matthew Mei, Saro H. Armenian, Hanjun Qin, Jeffrey N. Weitzel, Raju Pillai, Alex E. Pozhitkov, Jennifer Berano Teh, Kevin Karwing Tsang
Publikováno v:
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
Clonal hematopoiesis (CH), characterized by the accumulation of acquired somatic mutations in the blood, is associated with an elevated risk of aging-related diseases and premature mortality in non-cancer populations. Patients who undergo autologous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b181f8fb72d44c1e9d2ff8ad4a809ef
https://doi.org/10.1016/j.bbmt.2019.08.013
https://doi.org/10.1016/j.bbmt.2019.08.013
Autor:
Alex E. Pozhitkov, Naini Seth, Trilokesh D. Kidambi, Michael W. Lew, Srisairam Achuthan, John L. Raytis
BackgroundThe American Society of Anesthesiologists (ASA) Physical Status Classification System defines peri-operative patient scores as 1 (healthy) thru 6 (brain dead). The scoring is used by the anesthesiologists to classify surgical patients based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1943c4a432ad9071bd8f8c6b0e363a08
https://doi.org/10.1101/2021.10.05.21264585
https://doi.org/10.1101/2021.10.05.21264585
Autor:
Alex E Pozhitkov, Diane Daubert, Ashley Brochwicz Donimirski, Douglas Goodgion, Mikhail Y Vagin, Brian G Leroux, Colby M Hunter, Thomas F Flemmig, Peter A Noble, James D Bryers
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140393 (2015)
Peri-implantitis is an inflammatory disease that results in the destruction of soft tissue and bone around the implant. Titanium implant corrosion has been attributed to the implant failure and cytotoxic effects to the alveolar bone. We have document
Externí odkaz:
https://doaj.org/article/8879f13078dc4481b8adbc6091522481
Autor:
Yuan Chen, Grace Aldana-Masangkay, Li Du, Steven T. Rosen, Wei Liu, Flavia Pichiorri, Alex E. Pozhitkov
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-16 (2022)
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-16 (2022)
Background Multiple myeloma (MM) is an incurable plasma cell malignancy. Although Dexamethasone (Dex) is the most widely used therapeutic drug in MM treatment, patients develop Dex resistance leading to progressive disease, demanding an urgent need t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f2d2dbaf9d012581c1a51db1f5ed6e9
https://pubmed.ncbi.nlm.nih.gov/34983615
https://pubmed.ncbi.nlm.nih.gov/34983615
Autor:
Domenico Viola, Hongzhi Li, Xiwei Wu, Flavia Pichiorri, James F. Sanchez, Timothy W. Synold, Steven T. Rosen, Ralf Buettner, Michael Rosenzweig, Austin Christofferson, Amrita Krishnan, Jonathan J Keats, Alex E. Pozhitkov, Nagarajan Vaidehi, Estelle Troadec, Joycelynne Palmer, Jihane Khalife, Enrico Caserta, Guido Marcucci, Corey Morales, Emine Gulsen Gunes
Publikováno v:
Blood Advances. 3:1027-1032
Key Points Teriflunomide, the active metabolite of leflunomide, downregulates c-Myc expression through inhibition of PIM kinases. Leflunomide together with lenalidomide significantly extended survival in an in vivo MM model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8baa13a1c126dc88b70a6953690f13
https://doi.org/10.1182/bloodadvances.2018027227
https://doi.org/10.1182/bloodadvances.2018027227
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91295 (2014)
BackgroundAlthough microarrays are analysis tools in biomedical research, they are known to yield noisy output that usually requires experimental confirmation. To tackle this problem, many studies have developed rules for optimizing probe design and
Externí odkaz:
https://doaj.org/article/fdf5a812d497451fbe8f072c77f9784e
Autor:
Bolot Mambetsariev, Mohd W. Nasser, Ravi Salgia, Karen L. Reckamp, Yi-Hung Carol Tan, Tamara Mirzapoiazova, Yingyu Wang, Prakash Kulkarni, Alex E. Pozhitkov, Dan J. Raz, Ka Ming Pang, Yanfang Zheng, Surinder K. Batra, Yang Wang, Edward Wang, Jiale Wang
Publikováno v:
Cancer Biology & Therapy
The receptor tyrosine kinase MET is frequently involved in malignant transformation and inhibiting its activity in MET-dependent cancers is associated with improved clinical outcomes. Emerging evidence also suggests that mitochondria play an essentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23462e992b342091d0f35138bf62dfc1
https://doi.org/10.1080/15384047.2018.1472193
https://doi.org/10.1080/15384047.2018.1472193