Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Alex E Grill"'
Autor:
Matthew M Schaefers, Laura M Breshears, Michele J Anderson, Ying-Chi Lin, Alex E Grill, Jayanth Panyam, Peter J Southern, Patrick M Schlievert, Marnie L Peterson
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32813 (2012)
Staphylococcus aureus initiates infections and produces virulence factors, including superantigens (SAgs), at mucosal surfaces. The SAg, Toxic Shock Syndrome Toxin-1 (TSST-1) induces cytokine secretion from epithelial cells, antigen presenting cells
Externí odkaz:
https://doaj.org/article/c17c623621944dcd8060a4161ed46898
Autor:
Karin R. Vevang, Lin Zhang, Alex E. Grill, Dorothy K. Hatsukami, Ellen Meier, Sarah Oppeneer Nomura, Kim Robien, Lisa A. Peterson
Publikováno v:
Chemical Research in Toxicology. 36:157-161
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e86dd1ed06e29931debaf999ef825a4e
https://doi.org/10.1021/acs.chemrestox.2c00412
https://doi.org/10.1021/acs.chemrestox.2c00412
Autor:
Yen Yi Ho, Lin Zhang, Andrew DiLernia, Amanda Beauchamp, Lisa A. Peterson, Igor V. Ignatovich, Alex E. Grill
Publikováno v:
Chem Res Toxicol
Metabolic activation of many carcinogens leads to formation of reactive intermediates that form DNA adducts. These adducts are cytotoxic when they interfere with cell division. They can also cause mutations by miscoding during DNA replication. Theref
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a7162b7d1d30e5b8edfe81dc98433f
https://doi.org/10.1021/acs.chemrestox.9b00266
https://doi.org/10.1021/acs.chemrestox.9b00266
Publikováno v:
FASEB J
Oral consumption of curcumin, a natural polyphenol, is associated with reduced incidence of cancer. Yet, a significant amount of the orally dosed compound is eliminated in the feces, and a major fraction of the absorbed compound is metabolized to ina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a11879208430b6a3d44ccedfe6c4eef
https://pubmed.ncbi.nlm.nih.gov/31136203
https://pubmed.ncbi.nlm.nih.gov/31136203
Publikováno v:
Drug delivery and translational research. 8(2)
Curcumin has shown promising inhibitory activity against HER-2 positive tumor cells in vitro but suffers from poor oral bioavailability in vivo. Our lab has previously developed a polymeric microparticle formulation for sustained delivery of curcumin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc267cfa5c6ad0b49ac7bb046c66f97
https://pubmed.ncbi.nlm.nih.gov/28417445
https://pubmed.ncbi.nlm.nih.gov/28417445
Publikováno v:
Drug delivery and translational research. 4(4)
In spite of its well-documented anticancer chemopreventive and therapeutic activity, the clinical development of curcumin has been limited by its poor oral bioavailability. Curcumin has low aqueous solubility and undergoes extensive first pass metabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74fbc72dcef4c118b77b1e60daeba9f2
https://pubmed.ncbi.nlm.nih.gov/25422796
https://pubmed.ncbi.nlm.nih.gov/25422796
Autor:
Pramod Upadhyaya, Silvia Balbo, Pablo Leitzman, M. Gerard O'Sullivan, Bo Zhou, Sreekanth C. Narayanapillai, Chengguo Xing, Stephen S. Hecht, Junxuan Lu, Lisa A. Peterson, Alex E. Grill, Ahmad Ali Shaik
We have previously shown that kava and its flavokavain-free Fraction B completely blocked 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in A/J mice with a preferential reduction in NNK-induced O (6)-methylguanine (O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f188fe04fc647ce3b1d65d9299342abd
https://europepmc.org/articles/PMC4178470/
https://europepmc.org/articles/PMC4178470/
Autor:
Alex E. Grill, Judith A. Whittum-Hudson, Stephen Kalscheuer, Emilie Roger, Bharath Raja Guru, Ameya R. Kirtane, Jayanth Panyam
Publikováno v:
Molecular pharmaceutics. 9(7)
The oral absorption of drugs that have poor bioavailability can be enhanced by encapsulation in polymeric nanoparticles. Transcellular transport of nanoparticle-encapsulated drug, possibly through transcytosis, is likely the major mechanism through w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e76551d5d2055e4def5f823b9ece1f83
https://pubmed.ncbi.nlm.nih.gov/22670575
https://pubmed.ncbi.nlm.nih.gov/22670575
Autor:
Peter J. Southern, Jayanth Panyam, Ying Chi Lin, Matthew M. Schaefers, Marnie L. Peterson, Michele J. Anderson, Laura M. Breshears, Patrick M. Schlievert, Alex E. Grill
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32813 (2012)
PLoS ONE
PLoS ONE
Staphylococcus aureus initiates infections and produces virulence factors, including superantigens (SAgs), at mucosal surfaces. The SAg, Toxic Shock Syndrome Toxin-1 (TSST-1) induces cytokine secretion from epithelial cells, antigen presenting cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c6a59e7b8dbdf06c78769d953d6321
http://europepmc.org/articles/PMC3303796?pdf=render
http://europepmc.org/articles/PMC3303796?pdf=render
Publikováno v:
Cancer Research. 72:602-602
Our lab has developed novel curcumin loaded PLGA microparticles for effectively maintaining curcumin blood and tissue levels for at least 45 days. Efficacy of this system was tested in Balb-neuT mice, a transgenic model of HER2 driven breast cancer.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1eb3bfc088787b886e23635809d00455
https://doi.org/10.1158/1538-7445.am2012-602
https://doi.org/10.1158/1538-7445.am2012-602