Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Alex Dubrovskiy"'
Autor:
Steven A. Saenz, Andrea Local, Tiffany Carr, Arvind Shakya, Shivsmriti Koul, Haiqing Hu, Lisa Chourb, Justin Stedman, Jenna Malley, Laura Akullian D’Agostino, Veerabahu Shanmugasundaram, John Malona, C. Eric Schwartz, Lisa Beebe, Meghan Clements, Ganesh Rajaraman, John Cho, Lan Jiang, Alex Dubrovskiy, Matt Kreilein, Roman Shimanovich, Lawrence G. Hamann, Laure Escoubet, J. Michael Ellis
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
Retinoic acid receptor-related orphan nuclear receptor (ROR) γt is a member of the RORC nuclear hormone receptor family of transcription factors. RORγt functions as a critical regulator of thymopoiesis and immune responses. RORγt is expressed in m
Externí odkaz:
https://doaj.org/article/c77d178e9fdf4a27bb6fc2263243c22d
Autor:
Shivsmriti Koul, John Malona, Lisa Beebe, Laure Escoubet, Meghan Clements, Arvind Shakya, Veerabahu Shanmugasundaram, Lan Jiang, Lawrence G. Hamann, Matt M. Kreilein, Jenna Malley, C. Eric Schwartz, Roman Shimanovich, Ganesh Rajaraman, Alex Dubrovskiy, Laura Akullian D’Agostino, Justin Stedman, Andrea Local, J. Michael Ellis, Tiffany Carr, Steven A. Saenz, Haiqing Hu, John Cho, Lisa Chourb
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE, Vol 16, Iss 11, p e0248034 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 11, p e0248034 (2021)
PLoS ONE
Retinoic acid receptor-related orphan nuclear receptor (ROR) γt is a member of the RORC nuclear hormone receptor family of transcription factors. RORγt functions as a critical regulator of thymopoiesis and immune responses. RORγt is expressed in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43fdb7715b2c933851e25206e28f0210
https://doi.org/10.1101/2021.02.19.431952
https://doi.org/10.1101/2021.02.19.431952
Autor:
Andrew Scholte, Jinyu Liu, Maria Fitzgerald, Jie Ge, D. Niu, Haibo Liu, Beatriz Ospina, Michael Kothe, Laura Akullian D’Agostino, Joshua Murtie, Gang Zheng, Fangxian Sun, Elvis Shehu, Zhendong Zhu, Mcdonald Joseph John, Matthieu Barrague, Kelly Fahnoe, Darren Harvey, Mark Munson, Zhigang Wang, Jennifer Rocnik, Robert Tjin Tham Sjin, Keli Perron, Alex Dubrovskiy
Publikováno v:
ACS Med Chem Lett
[Image: see text] Hepatocellular carcinoma (HCC) accounts for a majority of primary liver cancer and is one of the most common forms of cancer worldwide. Aberrant signaling of the FGF19-FGFR4 pathway leads to HCC in mice and is hypothesized to be a d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee03507ad85093651df1a28b744e8bfd
https://pubmed.ncbi.nlm.nih.gov/33062171
https://pubmed.ncbi.nlm.nih.gov/33062171
Autor:
Prasoon Chaturvedi, Erica Evans, Russell Karp, Matthew T. Labenski, Heather Lounsbury, Martin I. Freed, Steven Richard Witowski, Hormoz Mazdiyasni, Richland Wayne Tester, M. Nacht, Sharon Aslanian, Michael Sheets, Russell C. Petter, Juswinder Singh, Zhendong Zhu, Alex Dubrovskiy, William F. Westlin
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 346:219-228
Targeted therapies that suppress B cell receptor (BCR) signaling have emerged as promising agents in autoimmune disease and B cell malignancies. Bruton's tyrosine kinase (Btk) plays a crucial role in B cell development and activation through the BCR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d61db1f19445091f3dba37c82d79cc38
https://doi.org/10.1124/jpet.113.203489
https://doi.org/10.1124/jpet.113.203489
Autor:
Robert Tjin, Kevin K. Lin, Juswinder Singh, Thia St. Martin, Henry J. Haringsma, Mitch Raponi, Kwangho Lee, Russell Karp, Kenichi Suda, Zhendong Zhu, Annette O. Walter, William F. Westlin, Deqiang Nu, Andrew M. Allen, Mariana Nacht, Tetsuya Mitsudomi, Petter Russell C, Alex Dubrovskiy
Publikováno v:
Cancer Research. 72:1791-1791
Introduction: Non-small cell lung cancer (NSCLC) patients with activating EGFR mutations initially respond well to the EGFR tyrosine kinase inhibitors (TKIs) erlotinib and gefitinib. However, clinical efficacy is limited by the development of resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e12b8a6fba2bbb64459423771ba4c75
https://doi.org/10.1158/1538-7445.am2012-1791
https://doi.org/10.1158/1538-7445.am2012-1791
Autor:
Russell C. Petter, Aravind Prasad, Michael Sheets, Robert Tjin Tham Sjin, Erica Evans, Zhendong Zhu, Thia St Martin, M. Nacht, Margit Hagel, Matthew Labinski, Juswinder Singh, Alex Dubrovskiy, William F. Westlin
Publikováno v:
MedChemComm. 3:780
Recently, the importance of targeted covalent inhibitors in addressing potency, selectivity and drug resistance has become of great interest, especially in the area of non-small cell lung cancer (NSCLC). Although several covalent EGFR TKIs that are a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d273198cd6351421bb3b7a99c518721
https://doi.org/10.1039/c2md20017a
https://doi.org/10.1039/c2md20017a
Autor:
Mitch Raponi, Henry J. Haringsma, Kwangho Lee, Russell Karp, Annette O. Walter, Thia St. Martin, Robert Tjin, Deqiang Niu, Petter Russell C, Alex Dubrovskiy, Mariana Nacht, William F. Westlin, Juswinder Singh, Andrew M. Allen, Zhendong Zhu, Kevin K. Lin
Publikováno v:
Molecular Cancer Therapeutics. 10:C189-C189
Introduction: Non-small cell lung cancer (NSCLC) patients with activating EGFR mutations initially respond well to EGFR tyrosine kinase inhibitors. However, clinical efficacy is limited by the development of resistance. The most common mechanism of r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3fe20ba3b377521f3594416a98e7d76
https://doi.org/10.1158/1535-7163.targ-11-c189
https://doi.org/10.1158/1535-7163.targ-11-c189