Prenatal gestational diabetes mellitus exposure and accelerated offspring DNA methylation age in early childhood

Autor: Stephanie Shiau, Leishen Wang, Huikun Liu, Yinan Zheng, Alex Drong, Brian T. Joyce, Jun Wang, Weiqin Li, Junhong Leng, Yun Shen, Ru Gao, Gang Hu, Lifang Hou, Andrea A. Baccarelli

Publikováno v: Epigenetics, Vol 16, Iss 2, Pp 186-195 (2021)

Background: We investigated the association between prenatal GDM exposure and offspring DNA methylation (DNAm) age at 3–10 years of age in the Tianjin GDM Observational Study. Methods: This study included 578 GDM and 578 non-GDM mother-child pairs.

Externí odkaz: https://doaj.org/article/ed38859407534e27a6e4a719a2e371c9

Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria.

Autor: Felix Day, Tugce Karaderi, Michelle R Jones, Cindy Meun, Chunyan He, Alex Drong, Peter Kraft, Nan Lin, Hongyan Huang, Linda Broer, Reedik Magi, Richa Saxena, Triin Laisk, Margrit Urbanek, M Geoffrey Hayes, Gudmar Thorleifsson, Juan Fernandez-Tajes, Anubha Mahajan, Benjamin H Mullin, Bronwyn G A Stuckey, Timothy D Spector, Scott G Wilson, Mark O Goodarzi, Lea Davis, Barbara Obermayer-Pietsch, André G Uitterlinden, Verneri Anttila, Benjamin M Neale, Marjo-Riitta Jarvelin, Bart Fauser, Irina Kowalska, Jenny A Visser, Marianne Andersen, Ken Ong, Elisabet Stener-Victorin, David Ehrmann, Richard S Legro, Andres Salumets, Mark I McCarthy, Laure Morin-Papunen, Unnur Thorsteinsdottir, Kari Stefansson, andMe Research Team, Unnur Styrkarsdottir, John R B Perry, Andrea Dunaif, Joop Laven, Steve Franks, Cecilia M Lindgren, Corrine K Welt

Publikováno v: PLoS Genetics, Vol 14, Iss 12, p e1007813 (2018)

Polycystic ovary syndrome (PCOS) is a disorder characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian morphology. Affected women frequently have metabolic disturbances including insulin resistance and dysregulation of glucose

Externí odkaz: https://doaj.org/article/c68abd5b52b94dbab11b2cca436008a6

Single-Cell Multi-Omics Defines the Cell-Type Specific Impact of SF3B1 Splicing Factor Mutations on Hematopoietic Differentiation in Human Clonal Hematopoiesis and Myelodysplastic Syndromes

Autor: Sissel Juul, Alex Drong, Xiaoguang Dai, Celine Chen, Ariel Swett, Ronan Chaligne, Irene M. Ghobrial, Scott F. Hickey, Neville Dusaj, Daniel H. Wiseman, Paulina Chamely, Justin Taylor, Tarek H. Mouhieddine, Allegra G. Hawkins, Lloyd Kluegel, Omar Abdel-Wahab, Franco Izzo, John Beaulaurier, Dan A. Landau, Eoghan D. Harrington, Federico Gaiti

Publikováno v: Blood. 138:145-145

Splicing factor mutations are recurrent genetic alterations in blood disorders, highlighting the importance of alternative splicing regulation in hematopoiesis. Specifically, mutations in splicing factor 3B subunit 1 (SF3B1) are implicated in the pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a76e4f51d5b389bcaeca9695f2837ea
https://doi.org/10.1182/blood-2021-147529

Body mass index stratified meta-analysis of genome-wide association studies of polycystic ovary syndrome in women of European ancestry.

Autor: Burns, Kharis^1,2 (AUTHOR) kharis.burns@research.uwa.edu.au, Mullin, Benjamin H.^3,4 (AUTHOR), Moolhuijsen, Loes M. E.⁵ (AUTHOR), Laisk, Triin⁶ (AUTHOR), Tyrmi, Jaakko S.^7,8 (AUTHOR), Cui, Jinrui⁹ (AUTHOR), Actkins, Ky'Era V.^10,11,12 (AUTHOR), Louwers, Yvonne V.¹³ (AUTHOR), Metspalu, Andres (AUTHOR), Milani, Lili (AUTHOR), Esko, Tõnu (AUTHOR), Nelis, Mari (AUTHOR), Hudjashov, Georgi (AUTHOR), Davis, Lea K.^11,12 (AUTHOR), Dudbridge, Frank¹⁴ (AUTHOR), Azziz, Ricardo¹⁵ (AUTHOR), Goodarzi, Mark O.⁹ (AUTHOR), Laivuori, Hannele^7,16,17,18 (AUTHOR), Mägi, Reedik⁶ (AUTHOR), Visser, Jenny A.⁵ (AUTHOR)

Publikováno v: BMC Genomics. 2/26/2024, Vol. 25 Issue 1, p1-15. 15p.

Prenatal gestational diabetes mellitus exposure and accelerated offspring DNA methylation age in early childhood.

Autor: Shiau, Stephanie, Wang, Leishen, Liu, Huikun, Zheng, Yinan, Drong, Alex, Joyce, Brian T., Wang, Jun, Li, Weiqin, Leng, Junhong, Shen, Yun, Gao, Ru, Hu, Gang, Hou, Lifang, Baccarelli, Andrea A.

Publikováno v: Epigenetics; Jan-Feb2021, Vol. 16 Issue 2, p186-195, 10p