Zobrazeno 1 - 10
of 428
pro vyhledávání: '"Alex Dickson"'
Autor:
Christian Greb, Esin Aktan, Roman Adam, Alex Dickson, Cédric Sire, Viktoria E. Nefedova, François Sylla, Rodrigo Lopez-Martens, Claus M. Schneider, Jérôme Faure, Markus Büscher
Publikováno v:
Instruments, Vol 8, Iss 3, p 40 (2024)
We present a laser–plasma electron accelerator module designed to be driven by high-repetition-rate lasers for industrial applications of laser-driven electron beams. It consists of a single vacuum chamber containing all the necessary components fo
Externí odkaz:
https://doaj.org/article/115d58da4b1045caa426e9ffef188be1
Autor:
Tom Dixon, Derek MacPherson, Barmak Mostofian, Taras Dauzhenka, Samuel Lotz, Dwight McGee, Sharon Shechter, Utsab R. Shrestha, Rafal Wiewiora, Zachary A. McDargh, Fen Pei, Rajat Pal, João V. Ribeiro, Tanner Wilkerson, Vipin Sachdeva, Ning Gao, Shourya Jain, Samuel Sparks, Yunxing Li, Alexander Vinitsky, Xin Zhang, Asghar M. Razavi, István Kolossváry, Jason Imbriglio, Artem Evdokimov, Louise Bergeron, Wenchang Zhou, Jagat Adhikari, Benjamin Ruprecht, Alex Dickson, Huafeng Xu, Woody Sherman, Jesus A. Izaguirre
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-24 (2022)
The formation of ternary degrader-protein complexes is a key step in the targeted degradation of proteins of interest. Here, the authors explore the structure and dynamics of such complexes applying high-performance computer simulations augmented wit
Externí odkaz:
https://doaj.org/article/c2e5bdee6705479cb8aa835a2985b507
Autor:
Samuel D. Lotz, Alex Dickson
Publikováno v:
ACS Omega, Vol 5, Iss 49, Pp 31608-31623 (2020)
Externí odkaz:
https://doaj.org/article/ab48f98d0c23492287862cf174e932b6
Autor:
Nicole M. Roussey, Alex Dickson
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Improper reaction coordinates can pose significant problems for path-based binding free energy calculations. Particularly, omission of long timescale motions can lead to over-estimation of the energetic barriers between the bound and unbound states.
Externí odkaz:
https://doaj.org/article/4481a80e6543426891530637a882e78c
Publikováno v:
Games, Vol 13, Iss 6, p 83 (2022)
We investigate observed rent dissipation—the ratio of the total costs of rent seeking to the monetary value of the rent—in winner-take-all and share contests, where preferences are more general than usually assumed in the literature. With concave
Externí odkaz:
https://doaj.org/article/f6072ba191694d9c8f5a337d7a00aee1
Autor:
Claire Soave, Charles Ducker, Naeyma Islam, Seongho Kim, Sally Yurgelevic, Nathan I. Nicely, Luke Pardy, Yanfang Huang, Peter E. Shaw, Gregory Auner, Alex Dickson, Manohar Ratnam
Publikováno v:
Molecular Pharmacology. 103:211-220
Autor:
Nicole M. Roussey, Alex Dickson
Publikováno v:
Journal of Computational Chemistry. 44:935-947
The prediction of (un)binding rates and free energies is of great significance to the drug design process. Although many enhanced sampling algorithms and approaches have been developed, there is not yet a reliable workflow to predict these quantities
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
The free energy of a process is the fundamental quantity that determines its spontaneity or propensity at a given temperature. In particular, the binding free energy of a drug candidate to its biomolecular target is used as an objective quantity in d
Externí odkaz:
https://doaj.org/article/a0097719619747808b7b6341dab3fe9b
Autor:
Rebecca J. Wood, Angelique R. Ormsby, Mona Radwan, Dezerae Cox, Abhishek Sharma, Tobias Vöpel, Simon Ebbinghaus, Mikael Oliveberg, Gavin E. Reid, Alex Dickson, Danny M. Hatters
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
A pool of quality control proteins (QC) maintains the protein-folding homeostasis in the cell, but its quantitative analysis is challenging. Here the authors develop a FRET sensor based on the protein barnase, able to quantify QC holdase activity and
Externí odkaz:
https://doaj.org/article/6391112b918e4b36a3854c8ea904fe80
Publikováno v:
The Scandinavian Journal of Economics. 124:677-708
We develop a generalized theory of resource conflict. We demonstrate that the existence of a resource curse (or blessing) relies on two fundamental elements: (i) market conditions; and (ii) the production technology or agents’ preferences, dependin