Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Alex Dexter"'
Autor:
Alex Dexter, Dimitrios Tsikritsis, Natalie A. Belsey, Spencer A. Thomas, Jenny Venton, Josephine Bunch, Marina Romanchikova
Publikováno v:
Journal of Molecular Pathology, Vol 3, Iss 3, Pp 168-181 (2022)
Digital pathology is revolutionising the analysis of histological features and is becoming more and more widespread in both the clinic and research. Molecular pathology extends the tissue morphology information provided by conventional histopathology
Externí odkaz:
https://doaj.org/article/f13033b1294e4748a06c222097a58975
Autor:
Marina Romanchikova, Spencer Angus Thomas, Alex Dexter, Mike Shaw, Ignacio Partarrieau, Nadia Smith, Jenny Venton, Michael Adeogun, David Brettle, Robert James Turpin
Publikováno v:
Journal of Pathology Informatics, Vol 13, Iss , Pp 100157- (2022)
Background: Pathology services experienced a surge in demand during the COVID-19 pandemic. Digitalisation of pathology workflows can help to increase throughput, yet many existing digitalisation solutions use non-standardised workflows captured in pr
Externí odkaz:
https://doaj.org/article/c7ad0b43cb304806aad039b74861d302
Autor:
Heather E. Hulme, Lynsey M. Meikle, Hannah Wessel, Nicole Strittmatter, John Swales, Carolyn Thomson, Anna Nilsson, Robert J. B. Nibbs, Simon Milling, Per E. Andren, C. Logan Mackay, Alex Dexter, Josephine Bunch, Richard J. A. Goodwin, Richard Burchmore, Daniel M. Wall
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Salmonella Typhimurium causes a self-limiting gastroenteritis that may lead to systemic disease. Bacteria invade the small intestine, crossing the intestinal epithelium from where they are transported to the mesenteric lymph nodes (MLNs) wit
Externí odkaz:
https://doaj.org/article/3a24c8a8c4bd40bd88a9c66a0de21e92
Autor:
Aateka Patel, Ewelina Hoffman, Doug Ball, Jan Klapwijk, Rory T. Steven, Alex Dexter, Josephine Bunch, Daniel Baker, Darragh Murnane, Victoria Hutter, Clive Page, Lea Ann Dailey, Ben Forbes
Publikováno v:
Pharmaceutics, Vol 11, Iss 7, p 345 (2019)
‘Foamy’ alveolar macrophages (FAM) observed in nonclinical toxicology studies during inhaled drug development may indicate drug-induced phospholipidosis, but can also derive from adaptive non-adverse mechanisms. Orally administered amiodarone is
Externí odkaz:
https://doaj.org/article/44dbe4fdc29849178e81e17d591fdd1c
Autor:
Johan Vande Voorde, Arafath K. Najumudeen, Rory T. Steven, Chelsea J. Nikula, Alex Dexter, Lucas B. Zeiger, Efstathios A. Elia, Ammar Nasif, Ariadna Gonzalez-Fernandez, Teresa Murta, Michael Gillespie, Catriona A. Ford, Tamsin R.M. Lannagan, Nikola Vlahov, Rachel A. Ridgway, Colin Nixon, Kathryn Gilroy, David M. Gay, Amy Burton, Bin Yan, Katherine Sellers, Vincen Wu, Yuchen Xiang, Engy Shokry, William Clark, Vivian S.W. Li, Simon T. Barry, Richard J.A. Goodwin, Zoltan Takats, Oliver D.K. Maddocks, David Sumpton, Mariia O. Yuneva, Andrew D. Campbell, Josephine Bunch, Owen J. Sansom
With colorectal cancer (CRC) being the second most common cause of cancer-related deaths worldwide1, there is an urgent need for better diagnostic tools and new, more targeted therapies. Here we used genetically engineered mouse models (GEMMs), and m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d49a1f23b41d8dcc99c9cad29a72865
https://doi.org/10.1101/2023.03.12.531945
https://doi.org/10.1101/2023.03.12.531945
Autor:
Adam J. Taylor, Dimitrios Tsikritsis, Alex Dexter, Amy Burton, Josephine Bunch, Natalie A. Belsey
Publikováno v:
Journal of Chemometrics. 36
Autor:
Bin Yan, Chelsea J. Nikula, Owen J. Sansom, Spencer A. Thomas, Teresa Murta, Rory T. Steven, Alex Dexter, Andrew D. Campbell, Efstathios A Elia, Richard J. A. Goodwin, Zoltan Takats, Josephine Bunch, Lucas B. Zeiger
Publikováno v:
Analytical Chemistry. 93:2309-2316
Mass spectrometry imaging can produce large amounts of complex spectral and spatial data. Such data sets are often analyzed with unsupervised machine learning approaches, which aim at reducing their complexity and facilitating their interpretation. H
Autor:
Owen J. Sansom, John R. P. Knight, Simon T. Barry, Rachel A. Ridgway, David Sumpton, Rory T. Steven, Giovanny Rodriguez-Blanco, Eyal Gottlieb, Gaurav Malviya, William C. Clark, Douglas Strathdee, Emma R. Johnson, Holly Hall, Alex Dexter, Teresa Murta, David Y. Lewis, Saverio Tardito, Gregory Hamm, Gavin Brown, Colin Nixon, Kathryn Gilroy, Zoltan Takats, Sudhir B Malla, Dmitry Solovyev, Sigrid K. Fey, Fatih Ceteci, Gillian M. Mackay, Susan E. Critchlow, Ann Hedley, Nikola Vlahov, Alan M. Race, Martin Bushell, Andrew D. Campbell, Arafath Kaja Najumudeen, Richard J. A. Goodwin, Josephine Bunch, Chelsea J. Nikula, Agata Mrowinska, Philip D Dunne, Rene Jackstadt, Joshua D.G. Leach
Publikováno v:
Nature Genetics. 53:16-26
Oncogenic KRAS mutations and inactivation of the APC tumor suppressor co-occur in colorectal cancer (CRC). Despite efforts to target mutant KRAS directly, most therapeutic approaches focus on downstream pathways, albeit with limited efficacy. Moreove
Autor:
Alex Dexter, Doug Ball, Aateka Patel, Clive P. Page, Lea Ann Dailey, Josephine Bunch, Ben Forbes, Jan Klapwijk, Rory T. Steven, Adam J. Taylor
Publikováno v:
Analytical and Bioanalytical Chemistry
Within drug development and pre-clinical trials, a common, significant and poorly understood event is the development of drug-induced lipidosis in tissues and cells. In this manuscript, we describe a mass spectrometry imaging strategy, involving repe
Autor:
M Shaw, Alex Dexter, Chelsea J. Nikula, Teresa Murta, C Dondi, I Partarrieu, J Venton, Spencer A. Thomas, Josephine Bunch, M Romanchikova, N Smith, Adam J. Taylor, M Adeogun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ced9f8211adfe011183351f4eca46054
https://doi.org/10.47120/npl.as102
https://doi.org/10.47120/npl.as102