Propagation of temporal and rate signals in cultured multilayer networks

Autor: Jérémie Barral, Xiao-Jing Wang, Alex D. Reyes

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

The nature of the signals that propagate through feedforward networks is not well understood. Here, the authors combine microfabrication, multilayer cortical cultures, and optogenetic stimulation to show that NMDA-mediated synaptic current generates

Externí odkaz: https://doaj.org/article/d5e4b1225b22452ebff3e4d288959398

Mathematical framework for place coding in the auditory system

Autor: Alex D. Reyes

Publikováno v: PLoS Computational Biology, Vol 17, Iss 8, p e1009251 (2021)
PLoS Computational Biology

In the auditory system, tonotopy is postulated to be the substrate for a place code, where sound frequency is encoded by the location of the neurons that fire during the stimulus. Though conceptually simple, the computations that allow for the repres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea2907189dc61d71d59fac593cc7d375
https://doaj.org/article/90f15faace2b48958af6992d5ec7fb25

Voluntary Wheel Running Exercise Evoked by Food-Restriction Stress Exacerbates Weight Loss of Adolescent Female Rats But Also Promotes Resilience by Enhancing GABAergic Inhibition of Pyramidal Neurons in the Dorsal Hippocampus

Autor: Chiye Aoki, Yi Wen Chen, Kei Tateyama, Alex D. Reyes, Jia Yi Wang, Irene Yu, Tara G. Chowdhury, Gauri S. Wable

Publikováno v: Cereb Cortex

Adolescence is marked by increased vulnerability to mental disorders and maladaptive behaviors, including anorexia nervosa. Food-restriction (FR) stress evokes foraging, which translates to increased wheel running exercise (EX) for caged rodents, a m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::804bd7b190c15a5ab1beaa7fbe8791f5
https://doi.org/10.1093/cercor/bhy283

Propagation of temporal and rate signals in cultured multilayer networks

Autor: Xiao Jing Wang, Alex D. Reyes, Jérémie Barral

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), ⟨10.1038/s41467-019-11851-0⟩
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

Analyses of idealized feedforward networks suggest that several conditions have to be satisfied in order for activity to propagate faithfully across layers. Verifying these concepts experimentally has been difficult owing to the vast number of variab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::310493d36d7dc0b622e6af996a7c6d8e
http://europepmc.org/articles/PMC6722076

A breakthrough method that became vital to neuroscience

Autor: Alex D. Reyes

Publikováno v: Nature. 575:38-39

Originally developed to record currents of ions flowing through channel proteins in the membranes of cells, the patch-clamp technique has become a true stalwart of the neuroscience toolbox. An innovative technique to record the electrical activity of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5793b6d8a4a31df09fc4381a06d24146
https://doi.org/10.1038/d41586-019-02836-6