Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Alex D. Hoffman"'
Autor:
Richard C. Kolanczyk, Laura E. Solem, Mark A. Tapper, Alex D. Hoffman, Barbara R. Sheedy, Patricia K. Schmieder, James M. McKim
Publikováno v:
Fishes, Vol 9, Iss 8, p 311 (2024)
The microsomal metabolism of phenol (11 °C) over an annual reproductive cycle from June to December was studied using fall spawning adult brook trout (Salvelinus fontinalis). Hepatic microsomes were isolated from three male and three female fish eac
Externí odkaz:
https://doaj.org/article/5b71169f2b4c48a39adcf6458b4b3392
Publikováno v:
Environmental Toxicology and Chemistry.
Publikováno v:
Environ Toxicol Chem
Environmental contaminants frequently occur as part of a chemical mixture, potentially resulting in competitive inhibition among multiple substrates metabolized by the same enzyme. Trout liver S9 fractions were used to evaluate the biotransformation
Publikováno v:
Environ Toxicol Chem
The activity of a trout liver S9 substrate depletion assay has been shown to decline over time, presumably due to proteolytic degradation of biotransformation enzymes. To address this problem, assay performance was evaluated following the addition of
Autor:
John A. Frew, Martin Sadilek, John W. Nichols, Christian E. Grue, Alex D. Hoffman, Patrick N. Fitzsimmons, Jacob T. Brown
Publikováno v:
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 205:34-42
Imidacloprid (IMI) is the largest selling insecticide internationally. Little is known about the toxicokinetics of IMI in fish, however. In vivo time-course studies were conducted to study the distribution and elimination of IMI in rainbow trout. Ani
Publikováno v:
Environ Toxicol Chem
The present study investigated the dietary bioaccumulation and biotransformation of hydrophobic organic sunscreen agents, 2-ethylhexyl-4-methoxycinnamate (EHMC) and octocrylene (OCT), in rainbow trout using a modified Organisation for Economic Co-ope
Publikováno v:
Environmental Toxicology and Chemistry. 36:463-471
Isolated hepatocytes and liver S9 fractions have been used to collect in vitro biotransformation data for fish as a means of improving modeled estimates of chemical bioaccumulation. To date, however, there have been few direct comparisons of these 2
Autor:
John W. Nichols, Patricia A. Kosian, Alex D. Hoffman, Daniel M. Consoer, Patrick N. Fitzsimmons
Publikováno v:
Environmental Toxicology and Chemistry. 35:717-727
Rainbow trout (Oncorhynchus mykiss) confined to respirometer-metabolism chambers were dosed with perfluorooctane sulfonate (PFOS) by intra-arterial injection and sampled to obtain concentration time-course data for plasma and either urine or expired
Publikováno v:
Comparative biochemistry and physiology. Toxicologypharmacology : CBP. 214
Biotransformation may substantially impact the toxicity and accumulation of xenobiotic chemicals in fish. However, this activity can vary substantially within and among species. In this study, liver S9 fractions from rainbow trout (4–400 g) were us
Autor:
Jason P. Berninger, Russell J. Erickson, John W. Nichols, Bryan W. Brooks, C. Kevin Chambliss, Bowen Du, Alex D. Hoffman, Kristin A. Connors
Publikováno v:
Environmental Toxicology and Chemistry. 34:1425-1435
A need exists to better understand the influence of pH on the uptake and accumulation of ionizable pharmaceuticals in fish. In the present study, fathead minnows were exposed to diphenhydramine (DPH; disassociation constant = 9.1) in water for up to