Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Alex D Klausing"'
Publikováno v:
Psychopharmacology (Berl)
RATIONALE: Stress is related to cognitive impairments which are observed in most major brain diseases. Prior studies showed that the brain concentration of the tryptophan metabolite kynurenic acid (KYNA) is modulated by stress, and that changes in ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::688179b29f1994d52ddc2b293fc78895
https://doi.org/10.1007/s00213-020-05507-x
https://doi.org/10.1007/s00213-020-05507-x
Autor:
Shaowei Zhang, Robert Schwarcz, Derren J. Heyes, Carlo Breda, Christopher David Edlin, Flaviano Giorgini, Nigel S. Scrutton, Girdhar Singh Deora, Colin Levy, Kevin D. Read, Marina Wright Muelas, Douglas B. Kell, David Leys, Benjamin P. Ross, Philip J. R. Day, Alex D Klausing, Stephen O’Hagan, Michiyo Sakuma
Publikováno v:
Communications Biology, Vol 2, Iss 1, Pp 1-10 (2019)
Zhang, S, Sakuma, M, Deora, G S, Levy, C, Klausing, A, Breda, C, Read, K D, Ross, B P, Wright Muelas, M, Day, P, O'Hagan, S, Kell, D, Schwarcz, R, Leys, D, Heyes, D, Giorgini, F & Scrutton, N 2019, ' A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites ', Communications Biology . https://doi.org/10.1038/s42003-019-0520-5
Communications Biology
COMMUNICATIONS BIOLOGY
Zhang, S, Sakuma, M, Deora, G S, Levy, C, Klausing, A, Breda, C, Read, K D, Ross, B P, Wright Muelas, M, Day, P, O'Hagan, S, Kell, D, Schwarcz, R, Leys, D, Heyes, D, Giorgini, F & Scrutton, N 2019, ' A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites ', Communications Biology . https://doi.org/10.1038/s42003-019-0520-5
Communications Biology
COMMUNICATIONS BIOLOGY
Dysregulation of the kynurenine pathway (KP) leads to imbalances in neuroactive metabolites associated with the pathogenesis of several neurodegenerative disorders, including Huntington’s disease (HD). Inhibition of the enzyme kynurenine 3-monooxyg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cef15ca27e150c8aaa51693da774887
http://link.springer.com/article/10.1038/s42003-019-0520-5
http://link.springer.com/article/10.1038/s42003-019-0520-5