Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Alex Chitsazan"'
Autor:
Çiğdem Ak, Zeynep Sayar, Guillaume Thibault, Erik A. Burlingame, M.J. Kuykendall, Jennifer Eng, Alex Chitsazan, Koei Chin, Andrew C. Adey, Christopher Boniface, Paul T. Spellman, George V. Thomas, Ryan P. Kopp, Emek Demir, Young Hwan Chang, Vasilis Stavrinides, Sebnem Ece Eksi
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110668- (2024)
Summary: Mapping the spatial interactions of cancer, immune, and stromal cell states presents novel opportunities for patient stratification and for advancing immunotherapy. While single-cell studies revealed significant molecular heterogeneity in pr
Externí odkaz:
https://doaj.org/article/af29b6f146c548339d8565cc10e61ec6
Autor:
Sebnem Ece Eksi, Alex Chitsazan, Zeynep Sayar, George V. Thomas, Andrew J. Fields, Ryan P. Kopp, Paul T. Spellman, Andrew C. Adey
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
High tumour heterogeneity hinders the identification of molecular subtypes in prostate cancer. Here, the authors integrate single-cell chromatin accessibility data with multiplex imaging and reveal distinct chromatin features and transcriptional fact
Externí odkaz:
https://doaj.org/article/9f8c75a4a6604f2d9bd47a929b95d244
Autor:
Nikolas L. Jorstad, Matthew S. Wilken, Levi Todd, Connor Finkbeiner, Paul Nakamura, Nicholas Radulovich, Marcus J. Hooper, Alex Chitsazan, Brent A. Wilkerson, Fred Rieke, Thomas A. Reh
Publikováno v:
Cell Reports, Vol 30, Iss 7, Pp 2195-2208.e5 (2020)
Summary: Müller glia (MG) serve as sources for retinal regeneration in non-mammalian vertebrates. We find that this process can be induced in mouse MG, after injury, by transgenic expression of the proneural transcription factor Ascl1 and the HDAC i
Externí odkaz:
https://doaj.org/article/92d77537dc5a471fb270672b687e7c22
Autor:
Akshayalakshmi Sridhar, Akina Hoshino, Connor R. Finkbeiner, Alex Chitsazan, Li Dai, Alexandra K. Haugan, Kayla M. Eschenbacher, Dana L. Jackson, Cole Trapnell, Olivia Bermingham-McDonogh, Ian Glass, Thomas A. Reh
Publikováno v:
Cell Reports, Vol 30, Iss 5, Pp 1644-1659.e4 (2020)
Summary: To study the development of the human retina, we use single-cell RNA sequencing (RNA-seq) at key fetal stages and follow the development of the major cell types as well as populations of transitional cells. We also analyze stem cell (hPSC)-d
Externí odkaz:
https://doaj.org/article/301d277002ca428997541036a5fd4375
Autor:
Andy Wing Chun Pang, Karena Kosco, Nikhil Sahajpal, Arthi Sridhar, Jen Hauenstein, Benjamin Clifford, Joey Estabrook, Alex Chitsazan, Trilochan Sahoo, Anwar Iqbal, Ravindra Kolhe, Gordana Raca, Alex R. Hastie, Alka Chaubey
Structural variations (SVs) play a key role in the pathogenicity of hematological malignancies. Standard-of-care (SOC) methods such as karyotyping and fluorescencein situhybridization (FISH), employed globally for the past three decades have signific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3acdb39d23a193048996e091cf331449
https://doi.org/10.1101/2022.12.27.22283973
https://doi.org/10.1101/2022.12.27.22283973
Publikováno v:
Cancer Research. 83:2224-2224
Disease monitoring is important to detect cancer relapse, often as a result of a treatment-surviving cancer cell population. Detection of relapse is critical to determine the intensity and length of treatments and to predict the outcome of those trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9537b7c912582ae7d06db43c3d0cee7
https://doi.org/10.1158/1538-7445.am2023-2224
https://doi.org/10.1158/1538-7445.am2023-2224
Autor:
Ece Sebnem Eksi, Zeynep Sayar, Alex Chitsazan, George T. Thomas, Andrew Adey, Paul T. Spellman, Ryan Kopp
Publikováno v:
Cancer Research. 82:999-999
Identifying precise molecular subtypes attributable to specific stages of localized prostate cancer has proven difficult due to high levels of heterogeneity. Bulk assays represent a population-average, which mask the heterogeneity that exists at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1d06d2e90a2ac9bf57245c53a2e3772
https://doi.org/10.1158/1538-7445.am2022-999
https://doi.org/10.1158/1538-7445.am2022-999
Autor:
Beth L. Worley, Katherine Pelz, Grace McCarthy, Heike Mendez, Roberto Di Niro, Alex Chitsazan, Jonathan Brody, Aaron Grossberg
Publikováno v:
Cancer Research. 82:2373-2373
Objective: Cachexia, a wasting condition defined by chronic loss of fat and muscle, is a frequent complication of pancreatic ductal adenocarcinoma (PDAC) that negatively impacts quality of life and confers poor patient survival. Cachectic wasting can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9dc768f3db77c4e3b57edd7e00340ac
https://doi.org/10.1158/1538-7445.am2022-2373
https://doi.org/10.1158/1538-7445.am2022-2373
Autor:
Heather L Zebroski, Brent A. Wilkerson, Connor Finkbeiner, Alex Chitsazan, Renee C Zhang, Kylie E Beach, Nilasha Sen, Olivia Bermingham-McDonogh
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
This study provides transcriptomic characterization of the cells of the crista ampullaris, sensory structures at the base of the semicircular canals that are critical for vestibular function. We performed single-cell RNA-seq on ampullae microdissecte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4834c63e756a3f2e20d869ec23ca2a7d
https://doi.org/10.7554/elife.60108
https://doi.org/10.7554/elife.60108
Autor:
Nilasha Sen, Olivia Bermingham-McDonogh, Renee C Zhang, Kylie E Beach, Brent A. Wilkerson, Connor Finkbeiner, Heather L Zebroski, Alex Chitsazan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1517b74fdc1095555f8f4cbe07ebf71
https://doi.org/10.7554/elife.60108.sa2
https://doi.org/10.7554/elife.60108.sa2