Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Alex Chatel"'
Publikováno v:
Vaccine. 38(20)
The increasing importance of viral vaccine manufacturing has driven the need for high cell density process optimization that allows for higher production levels. Vero cells are one of the more popular adherent cell lines used for viral vaccine produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b6810421e4c6d029b148d3b0f605334
https://pubmed.ncbi.nlm.nih.gov/32247568
https://pubmed.ncbi.nlm.nih.gov/32247568
Publikováno v:
Current Opinion in Chemical Engineering. 14:150-157
The sensitivity of biological materials to shear stress conditions encountered during large-scale bioprocessing makes successful scale up from the bench challenging. Ultra scale-down technologies seek to use just millilitre quantities to enhance our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::502e7eae28e4551f8036a4d782ffe1e6
Publikováno v:
Biotechnology Progress
Ultra scale‐down (USD) methods operating at the millilitre scale were used to characterise full‐scale processing of E. coli fermentation broths autolysed to different extents for release of a domain antibody. The focus was on the primary clarific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8438bc7ee041c37e6d536d5707cae69b
https://doi.org/10.1002/btpr.2220
https://doi.org/10.1002/btpr.2220
Autor:
Alex Chatel, Andrea C. M. E. Rayat, Lara Fernandez-Cerezo, Jennifer M. Pollard, Mike Hoare, Gary J. Lye
Publikováno v:
Journal of Membrane Science. 596:117606
The lack of available material during early stage bioprocess development poses numerous processing challenges such as limiting the number of full-scale experiments. Extended fundamental process understanding could be gained with the use of an ultra s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e272a89d792ebfb800de75e04188dcb8
https://doi.org/10.1016/j.memsci.2019.117606
https://doi.org/10.1016/j.memsci.2019.117606
Autor:
Lara, Fernandez-Cerezo, Andrea C M E, Rayat, Alex, Chatel, Jennifer M, Pollard, Gary J, Lye, Michael, Hoare
Publikováno v:
Biotechnology and Bioengineering
The availability of material for experimental studies is a key constraint in the development of full‐scale bioprocesses. This is especially true for the later stages in a bioprocess sequence such as purification and formulation, where the product i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b4dcb1ac3536f3e58adb2a57b8b24790
https://pubmed.ncbi.nlm.nih.gov/30411315
https://pubmed.ncbi.nlm.nih.gov/30411315
Publikováno v:
Biotechnology and Bioengineering. 111:913-924
The processing of harvested E. coli cell broths is examined where the expressed protein product has been released into the extracellular space. Pre-treatment methods such as freeze–thaw, flocculation, and homogenization are studied. The resultant s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::717cadf5bc8bcb39dd73c7bb43b417c7
https://doi.org/10.1002/bit.25164
https://doi.org/10.1002/bit.25164
Publikováno v:
Biotechnology and bioengineering. 109(8)
An ultra scale-down (USD) device that provides insight of how industrial homogenization impacts bioprocess performance is desirable in the biopharmaceutical industry, especially at the early stage of process development where only a small quantity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b61d7ea5e58e28059bb08734a96473
https://pubmed.ncbi.nlm.nih.gov/22383367
https://pubmed.ncbi.nlm.nih.gov/22383367
Publikováno v:
New Biotechnology. 31:S115-S116
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c5e792016f708099e3fc59de710f1e4
https://doi.org/10.1016/j.nbt.2014.05.1891
https://doi.org/10.1016/j.nbt.2014.05.1891