Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Alex C. Y. Chang"'
Autor:
Gaspard Pardon, Alison S. Vander Roest, Orlando Chirikian, Foster Birnbaum, Henry Lewis, Erica A. Castillo, Robin Wilson, Aleksandra K. Denisin, Cheavar A. Blair, Colin Holbrook, Kassie Koleckar, Alex C. Y. Chang, Helen M. Blau, Beth L. Pruitt
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) are powerful in vitro models to study the mechanisms underlying cardiomyopathies and cardiotoxicity. Quantification of the contractile function in single hiPSC-CMs
Externí odkaz:
https://doaj.org/article/1069e53e6dc340f895ccdf08770ab256
Autor:
Tengfei Wang, Shuxiang Shi, Yuanyuan Shi, Peipei Jiang, Ganlu Hu, Qinying Ye, Zhan Shi, Kexin Yu, Chenguang Wang, Guoping Fan, Suwen Zhao, Hanhui Ma, Alex C. Y. Chang, Zhi Li, Qian Bian, Chao-Po Lin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Chemicals or drugs can accumulate within biomolecular condensates formed through phase separation in cells. Here, we use super-resolution imaging to search for chemicals that induce phase transition within chromatin at the microscale. This m
Externí odkaz:
https://doaj.org/article/3515f8cbf8e5467ab24066c5ddff6073
Publikováno v:
npj Regenerative Medicine, Vol 7, Iss 1, Pp 1-11 (2022)
Abstract Duchenne muscular dystrophy (DMD) is a progressive genetic myopathy that leads to heart failure from dilated cardiomyopathy by early adulthood. Recent evidence suggests that tamoxifen, a selective estrogen receptor modulator widely used to t
Externí odkaz:
https://doaj.org/article/bcc03fc6d7194bfeb4c491a1753444ab
Autor:
Alian Zhang, Li Fan, Xiaolu Bao, Zuojun Xu, Zhaofang Yin, Yang Zhuo, Junfeng Zhang, Jun Gu, Alex C. Y. Chang, Yuqi Fan, Changqian Wang
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2022)
BackgroundTelomere shortening, an indicator of aging, is associated with age-related diseases. This study aims to investigate the association between leukocyte telomere length (LTL) and thin-capped fibroatheromata (TCFA) and the impact of using LTL c
Externí odkaz:
https://doaj.org/article/8cce4f9f732a459394b655c6eb39603b
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Duchenne muscular dystrophy (DMD) related cardiomyopathy is the leading cause of early mortality in DMD patients. There is an urgent need to gain a better understanding of the disease molecular pathogenesis and develop effective therapies to prevent
Externí odkaz:
https://doaj.org/article/9c2b59bac3454e25bfe0b3324ccce876
The association of leukocyte telomere length and intermediate coronary lesions-a retrospective study
Autor:
Alian Zhang, Li Fan, Ting Sun, Yuqi Fan, Zuojun Xu, Zhaofang Yin, Yang Zhuo, Junfeng Zhang, Jun Gu, Alex C. Y. Chang, Changqian Wang
Publikováno v:
Annals of palliative medicine. 11(4)
Intermediate coronary lesions (40-70% stenosis) present a higher risk for future cardiovascular events for instability of plaques. Shortened telomere is an indicator of cellular senescence, which is associated with age-related diseases. However, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce077fa566d3a761a0a3e9f3cfa0f1b
https://pubmed.ncbi.nlm.nih.gov/34894710
https://pubmed.ncbi.nlm.nih.gov/34894710
Publikováno v:
NPJ Regenerative medicine. 7(1)
Duchenne muscular dystrophy (DMD) is a progressive genetic myopathy that leads to heart failure from dilated cardiomyopathy by early adulthood. Recent evidence suggests that tamoxifen, a selective estrogen receptor modulator widely used to treat brea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6ba17f0cc568d2ff9a89c3e5e331dd8
https://pubmed.ncbi.nlm.nih.gov/35304486
https://pubmed.ncbi.nlm.nih.gov/35304486
Autor:
Alex C Y, Chang, Victoria C, Garside, Michele, Fournier, Justin, Smrz, Pavle, Vrljicak, Patricia, Umlandt, Megan, Fuller, Gordon, Robertson, Yongjun, Zhao, Angela, Tam, Steven J M, Jones, Marco A, Marra, Pamela A, Hoodless, Aly, Karsan
Publikováno v:
Developmental dynamics : an official publication of the American Association of Anatomists. 243(7)
Valvuloseptal defects are the most common congenital heart defects. Notch signaling-induced endothelial-to-mesenchymal transition (EMT) in the atrioventricular canal (AVC) cushions at murine embryonic day (E)9.5 is a required step during early valve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a638ec516263283816586a467b6cb4e4
https://pubmed.ncbi.nlm.nih.gov/24633789
https://pubmed.ncbi.nlm.nih.gov/24633789
Autor:
Pavle Vrljicak, Rebecca Cullum, Eric Xu, Alex C Y Chang, Elizabeth D Wederell, Mikhail Bilenky, Steven J M Jones, Marco A Marra, Aly Karsan, Pamela A Hoodless
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40815 (2012)
Malformations of the cardiovascular system are the most common type of birth defect in humans, frequently affecting the formation of valves and septa. During heart valve and septa formation, cells from the atrio-ventricular canal (AVC) and outflow tr
Externí odkaz:
https://doaj.org/article/7250fa1161ad4d2f80e77930d2507243