Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Alex C. Minella"'
Loss of Fbxw7 triggers mammary tumorigenesis associated with E2F/c-Myc activation and Trp53 mutation
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 11, Pp 644-658 (2020)
Fbw7 is a tumor suppressor that regulates the degradation of oncogenic substrates such as c-Jun, c-Myc, Notch1 intracellular domain (ICD), and cyclin E by functioning as the substrate recognition protein in the Skp1-Cullin-F-box (SCF) ubiquitin ligas
Externí odkaz:
https://doaj.org/article/e98e9fee939c438fb87958eaec708063
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy, vol 29, iss 11
Mol Ther
Mol Ther
The development of CRISPR-derived genome editing technologies has enabled the precise manipulation of DNA sequences within the human genome. In this review, we discuss the initial development and cellular mechanism of action of CRISPR nucleases and D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb85bb0d9c00614a1cc660b322626041
https://doi.org/10.1016/j.ymthe.2021.09.027
https://doi.org/10.1016/j.ymthe.2021.09.027
Loss of Fbxw7 triggers mammary tumorigenesis associated with E2F/c-Myc activation and Trp53 mutation
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 11, Pp 644-658 (2020)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Fbw7 is a tumor suppressor that regulates the degradation of oncogenic substrates such as c-Jun, c-Myc, Notch1 intracellular domain (ICD), and cyclin E by functioning as the substrate recognition protein in the Skp1-Cullin-F-box (SCF) ubiquitin ligas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d07b03020077085bd898b3002eac5e6e
http://www.sciencedirect.com/science/article/pii/S1476558620301329
http://www.sciencedirect.com/science/article/pii/S1476558620301329
Autor:
Virginie Olive, Erich Sabio, Margaux J Bennett, Caitlin S De Jong, Anne Biton, James C McGann, Samantha K Greaney, Nicole M Sodir, Alicia Y Zhou, Asha Balakrishnan, Mona Foth, Micah A Luftig, Andrei Goga, Terence P Speed, Zhenyu Xuan, Gerard I Evan, Ying Wan, Alex C Minella, Lin He
Publikováno v:
eLife, Vol 2 (2013)
mir-17-92, a potent polycistronic oncomir, encodes six mature miRNAs with complex modes of interactions. In the Eμ-myc Burkitt’s lymphoma model, mir-17-92 exhibits potent oncogenic activity by repressing c-Myc-induced apoptosis, primarily through
Externí odkaz:
https://doaj.org/article/40ffbb1f349b467aad6234770c960db3
Autor:
Sridhar Rao, Kiran V. Paul, Joseph B. Fisher, Manoj M. Pillai, Tushar Murthy, Georg Seelig, Alexander B. Rosenberg, Abhishek K. Gupta, Alex C. Minella, Oscar Ramirez
Publikováno v:
Nucleic Acids Research
Cancer-associated mutations of the core splicing factor 3 B1 (SF3B1) result in selection of novel 3′ splice sites (3′SS), but precise molecular mechanisms of oncogenesis remain unclear. SF3B1 stabilizes the interaction between U2 snRNP and branch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6075be3da8bba614de1c6b3a64be266
https://doi.org/10.1093/nar/gky1161
https://doi.org/10.1093/nar/gky1161
Autor:
Sridhar Rao, Tushar Murthy, Michael Reimer, Alex C. Minella, Theresa Bluemn, Abhishek K. Gupta, Manoj M. Pillai
Publikováno v:
Journal of Biological Chemistry. 293:10220-10234
Splicing factor 3B1 (SF3B1) is a core splicing protein that stabilizes the interaction between the U2 snRNA and the branch point in the mRNA target during splicing. SF3B1 is heavily phosphorylated at its N terminus and a substrate of cyclin-dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e931b326eb5f05313307d65a4e471776
https://doi.org/10.1074/jbc.ra118.001654
https://doi.org/10.1074/jbc.ra118.001654
Autor:
Jonathan L. Kaufman, Ravi Vij, Suzanne Lentzsch, Anjali Sharma, Alex C. Minella, Deepu Madduri, Robin Lesley, Parameswaran Hari, Marc S. Raab, Andrew Spencer, Sikander Ailawadhi, Jeremy T. Larsen, Hans C. Lee, Prashant Kapoor, Zhao Yang, Faith E. Davies, Monique C. Minnema, Shinsuke Iida, Vijay V. Upreti, Simon J. Harrison
Publikováno v:
Blood. 136:28-29
Aims: To evaluate AMG 701, a BiTE® molecule binding BCMA on MM cells and CD3 on T cells, in RR MM (Amgen, NCT03287908); primary objective was to evaluate safety and tolerability and estimate a biologically active dose; secondary objectives were to c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d5656a3d092b1f5c81b3fdcbae6b7be
https://doi.org/10.1182/blood-2020-134063
https://doi.org/10.1182/blood-2020-134063
Autor:
Oscar Ramirez, Tushar Murthy, Alex C. Minella, Xiaodong Yang, Manoj M. Pillai, Abhishek K. Gupta, Anil K. Kesarwani
Publikováno v:
Oncogene
Recurrent mutations in core splicing factors have been reported in several clonal disorders, including cancers. Mutations in SF3B1, a component of the U2 splicing complex, are the most common. SF3B1 mutations are associated with aberrant pre-mRNA spl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc3bea3d9f7a6851043da657f7628cc
http://europepmc.org/articles/PMC5311031
http://europepmc.org/articles/PMC5311031
Autor:
J. Hudson, Ivor J. Benjamin, Qiang Dai, Justin L. P. Benesch, Elisabeth S. Christians, Rita Barresi, Alex C. Minella, Michael Grzybowski, Kate Bushby, Aron M. Geurts, Pattraranee Limphong, Elizabeth Wraige, Michael Riedel, Heinz Jungbluth, Mai T. Thao, Frances D.L. Kondrat, Shuping Lai, Huali Zhang, Melinda J. Choi, Wai-Meng Kwok, Qiang Lui, Graydon Taylor, Kurt D. Kolander, Katie A. Mitzelfelt
Publikováno v:
Mitzelfelt, K A, Limphong, P, Choi, M J, Kondrat, F D L, Lai, S, Kolander, K D, Kwok, W-M, Dai, Q, Grzybowski, M N, Zhang, H, Taylor, G M, Lui, Q, Thao, M T, Hudson, J A, Barresi, R, Bushby, K, Jungbluth, H, Wraige, E, Geurts, A M, Benesch, J L P, Riedel, M, Christians, E S, Minella, A C & Benjamin, I J 2016, ' Human 343delT HSPB5 Chaperone associated with Early-onset Skeletal Myopathy causes Defects in Protein Solubility ', Journal of Biological Chemistry . https://doi.org/10.1074/jbc.M116.730481
Mutations of HSPB5 (also known as CRYAB or αB-crystallin), a bona fide heat shock protein and molecular chaperone encoded by the HSPB5 (crystallin, alpha B) gene, are linked to various multisystem disorders featuring variable combinations of catarac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b85b51dad93daa504c4b792be2ca5fe7
https://doi.org/10.1074/jbc.m116.730481
https://doi.org/10.1074/jbc.m116.730481
Publikováno v:
Methods in Molecular Biology ISBN: 9781493988754
Mutational landscape of CLL is now known to include recurrent non-synonymous mutations in SF3B1, a core splicing factor. About 5-10% of newly diagnosed CLL harbor these mutations which are typically limited to HEAT domains in the carboxyl-terminus of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76f4fdbf2f0342fb490ec606d778a995
https://doi.org/10.1007/978-1-4939-8876-1_7
https://doi.org/10.1007/978-1-4939-8876-1_7
