Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Alex C. Lam"'
Publikováno v:
Genetics, 180(3), 1691-1698. GENETICS SOCIETY AMERICA
Combining global gene-expression profiling and genetic analysis of natural allelic variation (genetical genomics) has great potential in dissecting the genetic pathways underlying complex phenotypes. Efficient use of microarrays is paramount in exper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d486b6ba9cb4d508b08d292eef81dc5
https://doi.org/10.1534/genetics.108.090308
https://doi.org/10.1534/genetics.108.090308
Autor:
Georgina Bowden, Deborah J. Smyth, Jennifer Masters, Kjersti S. Rønningen, Jason D. Cooper, Felicity Payne, Neil Walker, Dag E. Undlien, John A. Todd, Alex C. Lam, Constantin Ionescu-Tirgoviste, Lisa Godfrey, Luc J. Smink, Rebecca Pask, Rebecca C.J. Twells, Oliver S. Burren, Cristian Guja, Sarah Nutland, Jeffrey S. Szeszko, Helen E. Rance, William Y.S. Wang
Publikováno v:
Biochemical and Biophysical Research Communications. 331:435-441
Susceptibility to the autoimmune disease type 1 diabetes has been linked to human chromosome 6q27 and, moreover, recently associated with one of the genes in the region, TATA box-binding protein (TBP). Using a much larger sample of T1D families than
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36fdc28ba894c85a338517722b5466b0
https://doi.org/10.1016/j.bbrc.2005.03.203
https://doi.org/10.1016/j.bbrc.2005.03.203
Autor:
Gustavo Glusman, Vincent H. Everett, Alex C. Lam, Erin Helton, Josyf C. Mychaleckyj, Geoffrey E. Dolman, Nathan Goodman, Davide Laneri, Linda S. Wicker, Christopher C. Cavnor, John A. Todd, Barry C. Healy, Daisy Flamez, Oliver S. Burren, Lee Rowen, Neil Walker, David B. Burdick, Yang Wang, Helen Schuilenburg, Decio L. Eizirik, Luc J. Smink
Publikováno v:
Nucleic Acids Research
NUCLEIC ACIDS RESEARCH
NUCLEIC ACIDS RESEARCH
T1DBase (http://T1DBase.org) is a public website and database that supports the type 1 diabetes (T1D) research community. The site is currently focused on the molecular genetics and biology of T1D susceptibility and pathogenesis. It includes the foll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb68e259ddd3e1dff611bc2402cbde5
http://europepmc.org/articles/PMC540049
http://europepmc.org/articles/PMC540049
Autor:
Dag E. Undlien, Constantin Ionescu-Tı̂irgovişte, David A. Savage, Cristian Guja, Bryan J. Barratt, Eva Tuomilehto-Wolf, Jason D. Cooper, Alex C. Lam, Christopher E. Lowe, John S. Hulme, Joanna M. M. Howson, John A. Todd, Rebecca C.J. Twells, Jaakko Tuomilehto, Luc J. Smink
Publikováno v:
Diabetes. 53:2479-2482
Prior data associating the expression of lymphocyte-specific protein tyrosine kinase (LCK) with type 1 diabetes, its critical function in lymphocytes, and the linkage of the region to diabetes in the nonobese diabetic (NOD) mouse model make LCK a pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f99c3c4878c8cfb02153cf63b8a0301f
https://doi.org/10.2337/diabetes.53.9.2479
https://doi.org/10.2337/diabetes.53.9.2479
Autor:
Bryan J. Barratt, Jason D. Cooper, Luc J. Smink, Alex C. Lam, John A. Todd, Helen E. Rance, Sarah Nutland, Neil Walker, Rebecca C.J. Twells, Rebecca Pask, Felicity Payne, Deborah J. Smyth
Publikováno v:
Diabetes. 53:505-509
The diabetes-prone BioBreeding (BB) and Komeda diabetes-prone (KDP) rats are both spontaneous animal models of human autoimmune, T-cell-associated type 1 diabetes. Both resemble the human disease, and consequently, susceptibility genes for diabetes f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::989e8a46ef7cfb8e27232a78dd7dbfd1
https://doi.org/10.2337/diabetes.53.2.505
https://doi.org/10.2337/diabetes.53.2.505
Autor:
Lisa M. Maier, E Tuomilehto-Wolf, Luc J. Smink, Joanna M. M. Howson, John A. Todd, Sarah Nutland, Jaakko Tuomilehto, Dag E. Undlien, Constantin Ionescu-Tirgoviste, David Clayton, Alex C. Lam, Cristian Guja, David A. Savage, Francesco Cucca, Helen E. Rance, Oliver S. Burren, Kjersti S. Rønningen, Deborah J. Smyth, Christopher Patterson, Neil Walker, Dennis Carson, Rebecca C.J. Twells
Publikováno v:
Genes & Immunity. 4:469-475
Variations in the interleukin 4 receptor A (IL4RA) gene have been reported to be associated with atopy, asthma, and allergy, which may occur less frequently in subjects with type 1 diabetes (T1D). Since atopy shows a humoral immune reactivity pattern
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4819da1b2b47dcb9a1cbbe8930956e87
https://doi.org/10.1038/sj.gene.6364007
https://doi.org/10.1038/sj.gene.6364007
Autor:
Timothy J. Foster, Pietro Speziale, Fiona M. Roche, Mark J. Pallen, Alex C. Lam, Ruth C. Massey, Nicholas P. J. Day, Livia Visai, Sharon J. Peacock
Publikováno v:
Microbiology. 149:643-654
Twenty-one genes encoding surface proteins belonging to the LPXTG family have been identified by in silico analysis of six Staphylococcus aureus genome sequences. Eleven genes encode previously described proteins, while 10 have not yet been character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6782ff116fea6a423b660340539915f7
https://doi.org/10.1099/mic.0.25996-0
https://doi.org/10.1099/mic.0.25996-0
Publikováno v:
Trends in Microbiology. 9:518-521
The tricorn protease is an archaeal protease that forms massive proteasome-like capsids with a hollow chamber. beta-Propeller and PDZ domains are thought to play a role in substrate selection. By analysis of predicted proteins from novel bacterial ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2129483fa72383b3f83aeb59b8a926b
https://doi.org/10.1016/s0966-842x(01)02199-0
https://doi.org/10.1016/s0966-842x(01)02199-0
Publikováno v:
Trends in Microbiology. 9:302-307
ADP-ribosylation is a post-translational modification that can be seen in many contexts, including as the primary mechanism of action of many important bacterial exotoxins. By data-mining complete and incomplete bacterial genome sequences, we have di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::545316016bfe7ab346d121ba1082b81e
https://doi.org/10.1016/s0966-842x(01)02074-1
https://doi.org/10.1016/s0966-842x(01)02074-1
Publikováno v:
Lam, A C, Powell, J, Wei, W-H, de Koning, D-J & Haley, C S 2009, ' A combined strategy for quantitative trait loci detection by genome-wide association ' vol. 3 Suppl 1, pp. S6 . DOI: 10.1186/1753-6561-3-S1-S6
BMC Proceedings
BMC Proceedings, Vol 3, Iss Suppl 1, p S6 (2009)
ResearcherID
BMC Proceedings
BMC Proceedings, Vol 3, Iss Suppl 1, p S6 (2009)
ResearcherID
Background We applied a range of genome-wide association (GWA) methods to map quantitative trait loci (QTL) in the simulated dataset provided by the 12th QTLMAS workshop in order to derive an effective strategy. Results A variance component linkage a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398b4398b53c84a57a1f94fb45fdcea7
https://doi.org/10.1186/1753-6561-3-s1-s6
https://doi.org/10.1186/1753-6561-3-s1-s6