Výsledky vyhledávání - "Alex C. Lafever"

Peer-Developed Modules on Basic Biostatistics and Evidence-Based Medicine Principles for Undergraduate Medical Education

Autor: Cody McIlvain, Jonathan S Taylor-Fishwick, Michelle Rogers-Johnson, Justin Yaworsky, Sean Whitty, April Adams Pace, Mark Schmitt, Anthony Pang, Alex C. Lafever, William Sherred-Smith, Daniel H Mai, Anca D. Dobrian

Publikováno v: MedEdPORTAL : the Journal of Teaching and Learning Resources
MedEdPORTAL, Vol 16 (2020)

Introduction Evidence-based medicine (EBM) is pivotal in shaping patient care, yet it is challenging to incorporate into undergraduate medical education (UME) due to a lack of dedicated resources within the preclinical curriculum. To address this cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e3f50a11a9262b4b9b009ec8e7fbc0
http://europepmc.org/articles/PMC7703476

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Unmet Clinical Need: Developing Prognostic Biomarkers and Precision Medicine to Forecast Early Tumor Relapse, Detect Chemo-Resistance and Improve Overall Survival in High-Risk Breast Cancer

Autor: Alex C. Lafever, Caroline Dasom Lee, Mary L. Guye, Rick J. Jansen, Robert E. Van Sciver, Richard A. Hoefer, Gagan K. Gupta, Amy H. Tang, Janet S. Winston, Billur Samli, Anthony Pang, Michael P. Lee, Angela M. Tang-Tan

Publikováno v: Annals of breast cancer and therapy

Chemo-resistant breast cancer is a major barrier to curative treatment for a significant number of women with breast cancer. Neoadjuvant chemotherapy (NACT) is standard first- line treatment for most women diagnosed with high-risk TNBC, HER2+, and lo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::269ce1c9aa3fc193a2ed3f86e8b17425
https://pubmed.ncbi.nlm.nih.gov/32542231

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Abstract 584: Conquering undruggable oncogenic K-RAS-driven incurable metastatic cancer, and delivering precision medicine at neoadjuvant settings

Autor: Cynthia A. Allen, Amber L. Collier, Elizaveta Svyatova, David Z. Chang, Janet S. Winston, L.D. Britt, Lauren L. Siewertsz van Reesema, Caroline Dasom Lee, Gloria M. Petersen, Michael P. Lee, Apoorva S. Iyer, Robert E. Van Sciver, Richard A. Hoefer, Kevin Kanda, Alex C. Lafever, Amy H. Tang

Publikováno v: Cancer Research. 78:584-584

SIAH is a new and potent anti-K-RAS drug target in human cancer. The oncogenic EGFR/HER2/K-RAS pathway activation is pivotal in driving uncontrolled tumor growth and systemic metastasis. Thus, counteracting ERBB/K-RAS hyperactivation in attempt to re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14c6e40e33ec478aa382e38b5d73103f
https://doi.org/10.1158/1538-7445.am2018-584

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A New Strategy to Control and Eradicate 'Undruggable' Oncogenic K-RAS-Driven Pancreatic Cancer: Molecular Insights and Core Principles Learned from Developmental and Evolutionary Biology

Autor: Alex C. Lafever, Angela M. Tang-Tan, Rebecca L. Schmidt, Minglei Bian, Lynn M. Matrisian, Robert E. Van Sciver, Vasilena Zheleva, Monicah N. Bwayi, Amber L. Collier, Lauren L. Siewertsz van Reesema, Caroline Dasom Lee, Gloria M. Petersen, Elizaveta Svyatova, Michael P. Lee, Amy H. Tang, Kevin Kanda

Publikováno v: Cancers

Oncogenic K-RAS mutations are found in virtually all pancreatic cancers, making K-RAS one of the most targeted oncoproteins for drug development in cancer therapies. Despite intense research efforts over the past three decades, oncogenic K-RAS has re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1307c42fb16d9d441c9a5731d9cccd5
https://doi.org/10.3390/cancers10050142

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