Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Alex C. Kwan"'
Autor:
Farhan Ali, Danielle M. Gerhard, Katherine Sweasy, Santosh Pothula, Christopher Pittenger, Ronald S. Duman, Alex C. Kwan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The authors show that a subanesthetic dose of ketamine markedly elevate calcium signals in apical dendritic spines in the mouse prefrontal cortex. This effect is driven by a local-circuit mechanism that involves the suppression of somatostatin intern
Externí odkaz:
https://doaj.org/article/8227533bb0654c70a5cd7563059e67a7
Autor:
Clara Liao, Alex C. Kwan
Publikováno v:
Chronic Stress, Vol 5 (2021)
Rodent models are an invaluable tool for studying the pathophysiological mechanisms underlying stress and depressive disorders. However, the widely used behavioral assays to measure depressive-like states in rodents have serious limitations. In this
Externí odkaz:
https://doaj.org/article/7a17bc31b3f946c3b348d6a25c064676
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Investigating cell death in living organisms is hampered by a lack of techniques to induce apoptosis with spatial and temporal precision without collateral damage. Here the authors develop two-photon chemical apoptotic targeted ablation (2Phatal), al
Externí odkaz:
https://doaj.org/article/1d11ab96b908497fa624c67b497b8069
Autor:
Farhan Ali, Danielle M. Gerhard, Katherine Sweasy, Santosh Pothula, Christopher Pittenger, Ronald S. Duman, Alex C. Kwan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20634-x
Externí odkaz:
https://doaj.org/article/a4c5251e83b4474dad44088c83419c3b
Publikováno v:
Cognitive, Affective, & Behavioral Neuroscience.
Autor:
Sarah J. Jefferson, Ian Gregg, Mark Dibbs, Clara Liao, Hao Wu, Pasha A. Davoudian, Samuel C. Woodburn, Patrick H. Wehrle, Jeffrey S. Sprouse, Alexander M. Sherwood, Alfred P. Kaye, Christopher Pittenger, Alex C. Kwan
Publikováno v:
Neuropsychopharmacology.
Autor:
Lieselot L.G. Carrette, Adam Kimbrough, Pasha A. Davoudian, Alex C. Kwan, Andres Collazo, Olivier George
Publikováno v:
eNeuro, vol 10, iss 6
bioRxiv
bioRxiv
Chronic nicotine results in dependence with withdrawal symptoms upon discontinuation of use, through desensitization of nicotinic acetylcholine receptors and altered cholinergic neurotransmission. Nicotine withdrawal is associated with increased whol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9acfd51182b08647c610b958d2d3ce3d
https://doi.org/10.1101/2023.03.29.534836
https://doi.org/10.1101/2023.03.29.534836
Publikováno v:
Curr Biol
Psychedelics are compounds that alter consciousness by acting on serotonin receptors in the brain. The term 'psychedelic', from the Greek for mind manifesting, refers to the drugs' subjective effects and was first proposed by Humphry Osmond in 1956.
Autor:
Sarah J. Jefferson, Ian Gregg, Mark Dibbs, Clara Liao, Hao Wu, Pasha A. Davoudian, Jeffrey S. Sprouse, Alexander M. Sherwood, Alfred P. Kaye, Christopher Pittenger, Alex C. Kwan
Serotonergic psychedelics are gaining increasing interest as potential therapeutics for a range of mental illnesses. Compounds with short-lived subjective effects may be clinically useful because dosing time would be reduced, which may improve patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e5a5ec2b0e54fcc34b1df2125a7c46c
https://doi.org/10.1101/2022.11.03.515044
https://doi.org/10.1101/2022.11.03.515044
Autor:
Wen-Liang Zhou, Kristen Kim, Farhan Ali, Steven T. Pittenger, Cali A. Calarco, Yann S. Mineur, Charu Ramakrishnan, Karl Deisseroth, Alex C. Kwan, Marina R. Picciotto
Publikováno v:
Science advances. 8(42)
Dopamine signaling from the ventral tegmental area (VTA) plays critical roles in reward-related behaviors, but less is known about the functions of neighboring VTA GABAergic neurons. We show here that a primary target of VTA GABA projection neurons i