Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Alex C. Keene"'
Autor:
Rachel L. Moran, Emilie J. Richards, Claudia Patricia Ornelas-García, Joshua B. Gross, Alexandra Donny, Jonathan Wiese, Alex C. Keene, Johanna E. Kowalko, Nicolas Rohner, Suzanne E. McGaugh
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Laboratory studies have demonstrated that a single phenotype can be produced by many different genotypes; however, in natural systems, it is frequently found that phenotypic convergence is due to parallel genetic changes. This suggests a sub
Externí odkaz:
https://doaj.org/article/e1ecb67146714372a74c4bc5a5a56f23
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102517- (2023)
Summary: In this protocol, we describe a comparative approach to study the evolution of brain function in the Mexican tetra, Astyanax mexicanus. We developed surface fish and two independent populations of cavefish with pan-neuronal expression of the
Externí odkaz:
https://doaj.org/article/28953b50d8854651b088ad39ef4e4eec
Autor:
Alexandra Paz, Karla J. Holt, Anik Clarke, Ari Aviles, Briana Abraham, Alex C. Keene, Erik R. Duboué, Yaouen Fily, Johanna E. Kowalko
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107431- (2023)
Summary: Collective motion emerges from individual interactions which produce group-wide patterns in behavior. While adaptive changes to collective motion are observed across animal species, how local interactions change when these collective behavio
Externí odkaz:
https://doaj.org/article/064040fd6306475da05d78670e68ee4e
Autor:
Roberto Rodriguez-Morales, Paola Gonzalez-Lerma, Anders Yuiska, Ji Heon Han, Yolanda Guerra, Lina Crisostomo, Alex C. Keene, Erik R. Duboue, Johanna E. Kowalko
Publikováno v:
BMC Ecology and Evolution, Vol 22, Iss 1, Pp 1-15 (2022)
Abstract Background Aggression is observed across the animal kingdom, and benefits animals in a number of ways to increase fitness and promote survival. While aggressive behaviors vary widely across populations and can evolve as an adaptation to a pa
Externí odkaz:
https://doaj.org/article/9fda268271e64db1a61398f1dd34f380
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Chronic adversity in early childhood is associated with increased anxiety and a propensity for substance abuse later in adulthood, yet the effects of early life stress (ELS) on brain development remain poorly understood. The zebrafish, Danio
Externí odkaz:
https://doaj.org/article/581ded49db87447b8c38c0fc8e8ada52
Autor:
Valentina Botero, Bethany A. Stanhope, Elizabeth B. Brown, Eliza C. Grenci, Tamara Boto, Scarlet J. Park, Lanikea B. King, Keith R. Murphy, Kenneth J. Colodner, James A. Walker, Alex C. Keene, William W. Ja, Seth M. Tomchik
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Neurofibromatosis type 1 (NF1) is a genetic disorder caused by mutations in neurofibromin and associated with disruptions in physiology and behavior. Here the authors show that neurofibromin regulates metabolic homeostasis via a discrete brain circui
Externí odkaz:
https://doaj.org/article/9bdfedfd53ef4415959b9f694b37b1af
Publikováno v:
Biochemistry and Biophysics Reports, Vol 30, Iss , Pp 101280- (2022)
The ability of organisms to sense their nutritional environment and adjust their behavior accordingly is critical for survival. Insulin-like peptides (ilps) play major roles in controlling behavior and metabolism; however, the tissues and cells that
Externí odkaz:
https://doaj.org/article/657b1cde006f4d0b87cade3dc9096e52
Autor:
Wesley C. Warren, Tyler E. Boggs, Richard Borowsky, Brian M. Carlson, Estephany Ferrufino, Joshua B. Gross, LaDeana Hillier, Zhilian Hu, Alex C. Keene, Alexander Kenzior, Johanna E. Kowalko, Chad Tomlinson, Milinn Kremitzki, Madeleine E. Lemieux, Tina Graves-Lindsay, Suzanne E. McGaugh, Jeffrey T. Miller, Mathilda T. M. Mommersteeg, Rachel L. Moran, Robert Peuß, Edward S. Rice, Misty R. Riddle, Itzel Sifuentes-Romero, Bethany A. Stanhope, Clifford J. Tabin, Sunishka Thakur, Yoshiyuki Yamamoto, Nicolas Rohner
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Mexican Tetra cavefish have long been of interest in understanding adaptation to severe environmental change. Here the authors present a chromosome-level genome for the proxy-ancestral surface fish, and use CRISPR gene-editing to show the role of the
Externí odkaz:
https://doaj.org/article/e0b3331ea2974ca4af008dc49760b084
Autor:
Rachel L. Moran, James B. Jaggard, Emma Y. Roback, Alexander Kenzior, Nicolas Rohner, Johanna E. Kowalko, Claudia Patricia Ornelas-García, Suzanne E. McGaugh, Alex C. Keene
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103778- (2022)
Summary: Introgressive hybridization may play an integral role in local adaptation and speciation (Taylor and Larson, 2019). In the Mexican tetra Astyanax mexicanus, cave populations have repeatedly evolved traits including eye loss, sleep loss, and
Externí odkaz:
https://doaj.org/article/749872d3f675472d9811dc4df10e564c
Autor:
Maria E. Yurgel, Kreesha D. Shah, Elizabeth B. Brown, Carter Burns, Ryan A. Bennick, Justin R. DiAngelo, Alex C. Keene
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 11, Pp 3385-3395 (2018)
Metabolic state is a potent modulator of sleep and circadian behavior, and animals acutely modulate their sleep in accordance with internal energy stores and food availability. Across phyla, hormones secreted from adipose tissue act in the brain to c
Externí odkaz:
https://doaj.org/article/2a55de5e372549fea87855861029d0ed