Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Alex C. Conner"'
Autor:
Philip Kitchen, Mootaz M. Salman, Mohammed Abir-Awan, Tamim Al-Jubair, Susanna Törnroth- Horsefield, Alex C. Conner, Roslyn M. Bill
Publikováno v:
STAR Protocols, Vol 1, Iss 3, Pp 100157- (2020)
Summary: Aquaporins (AQPs) are membrane channel proteins that facilitate the movement of water down osmotic gradients across biological membranes. This protocol allows measurements of AQP-mediated water transport across the plasma membrane of live ma
Externí odkaz:
https://doaj.org/article/09f4c22380c54f5eb2674a12b11cd820
Autor:
Mootaz M. Salman, Philip Kitchen, M. Nicola Woodroofe, Roslyn M. Bill, Alex C. Conner, Paul R. Heath, Matthew T. Conner
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
Hypothermia is increasingly used as a therapeutic measure to treat brain injury. However, the cellular mechanisms underpinning its actions are complex and are not yet fully elucidated. Astrocytes are the most abundant cell type in the brain and are l
Externí odkaz:
https://doaj.org/article/c8691420063745908904d0e3c1ebc902
Publikováno v:
Cells, Vol 7, Iss 10, p 174 (2018)
After injury to the spinal cord, edema contributes to the underlying detrimental pathophysiological outcomes that lead to worsening of function. Several related membrane proteins called aquaporins (AQPs) regulate water movement in fluid transporting
Externí odkaz:
https://doaj.org/article/5b6cbc5b9c334e44a84f9fba54adf8e8
Autor:
Alex C. Conner, Philip Kitchen, Jordan Jennings, Mootaz M. Salman, Matthew T. Conner, Simone U. Pickel, Susanna Törnroth-Horsefield, Roslyn M. Bill
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
Aquaporins (AQPs) are a ubiquitous family of transmembrane water channel proteins. A subgroup of AQP water channels also facilitates transmembrane diffusion of small, polar solutes. A constriction within the pore, the aromatic/arginine (ar/R) selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd5f49cd27bb9556ae61a7a30f91320
http://link.springer.com/article/10.1038/s41598-019-56814-z
http://link.springer.com/article/10.1038/s41598-019-56814-z
Autor:
Chandy George, Israel Hanukoglu, Aguan D. Wei, Jane F. Armstrong, John A. Peters, Roslyn M. Bill, Steve A.N. Goldstein, Lucia G. Sivilotti, Mootaz M. Salman, Heike Wulff, Paul Davies, Michael Zhu, Stephan Kellenberger, Elena Faccenda, Michael F. Jarvis, Dejian Ren, Stefanie Fenske, Emma L. Veale, Jörg Striessnig, Verena Hammelmann, Brian F. King, Terrance P. Snutch, Trevor G. Smart, Leonard K. Kaczmarek, Brenda T. Winn, Eamonn Kelly, Philip Kitchen, Richard W. Aldrich, Jamie A. Davies, Charlotte Van den Eynde, Lachlan D. Rash, Edward Perez-Reyes, Elvir Becirovic, Christopher Southan, Joris Vriens, William A. Catterall, Jinbin Tian, Martin Biel, Adam J. Pawson, Leigh D. Plant, Alistair Mathie, Kotdaji Ha, James S. Trimmer, Bernard Attali, Anders A. Jensen, Lixia Yue, Joseph W. Lynch, Austin M. Baggetta, Haoxing Xu, Charles Kennedy, Xiaoli Zhang, Stephen P.H. Alexander, Simon D. Harding, Markus Delling, Simonetta Falzoni, Stephan Grissmer, Francesco Di Virgilio, Alex C. Conner
Publikováno v:
British journal of pharmacology, vol. 178 Suppl 1, pp. S157-S245
Alexander, S P, Mathie, A, Peters, J A, Veale, E L, Striessnig, J, Kelly, E, Armstrong, J F, Faccenda, E, Harding, S D, Pawson, A J, Southan, C, Davies, J A, Aldrich, R W, Attali, B, Baggetta, A M, Becirovic, E, Biel, M, Bill, R M, Catterall, W A, Conner, A C, Davies, P, Delling, M, Virgilio, F D, Falzoni, S, Fenske, S, George, C, Goldstein, S A N, Grissmer, S, Ha, K, Hammelmann, V, Hanukoglu, I, Jarvis, M, Jensen, A A, Kaczmarek, L K, Kellenberger, S, Kennedy, C, King, B, Kitchen, P, Lynch, J W, Perez-Reyes, E, Plant, L D, Rash, L, Ren, D, Salman, M M, Sivilotti, L G, Smart, T G, Snutch, T P, Tian, J, Trimmer, J S, Van den Eynde, C, Vriens, J, Wei, A D, Winn, B T, Wulff, H, Xu, H, Yue, L, Zhang, X & Zhu, M 2021, ' The concise guide to pharmacology 2021/22 : Ion channels ', British Journal of Pharmacology, vol. 178, no. Suppl. 1, pp. S157-S245 . https://doi.org/10.1111/bph.15539
Alexander, S P, Mathie, A, Peters, J A, Veale, E L, Striessnig, J, Kelly, E, Armstrong, J F, Faccenda, E, Harding, S D, Pawson, A J, Southan, C, Davies, J A, Aldrich, R W, Attali, B, Baggetta, A M, Becirovic, E, Biel, M, Bill, R M, Catterall, W A, Conner, A C, Davies, P, Delling, M, Virgilio, F D, Falzoni, S, Fenske, S, George, C, Goldstein, S A N, Grissmer, S, Ha, K, Hammelmann, V, Hanukoglu, I, Jarvis, M, Jensen, A A, Kaczmarek, L K, Kellenberger, S, Kennedy, C, King, B, Kitchen, P, Lynch, J W, Perez-Reyes, E, Plant, L D, Rash, L, Ren, D, Salman, M M, Sivilotti, L G, Smart, T G, Snutch, T P, Tian, J, Trimmer, J S, Van den Eynde, C, Vriens, J, Wei, A D, Winn, B T, Wulff, H, Xu, H, Yue, L, Zhang, X & Zhu, M 2021, ' The concise guide to pharmacology 2021/22 : Ion channels ', British Journal of Pharmacology, vol. 178, no. Suppl. 1, pp. S157-S245 . https://doi.org/10.1111/bph.15539
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d921561f4575efc693e15cc0f59fd20
https://serval.unil.ch/resource/serval:BIB_8F1855C9FD25.P001/REF.pdf
https://serval.unil.ch/resource/serval:BIB_8F1855C9FD25.P001/REF.pdf
Autor:
Susanna Törnroth-Horsefield, Mootaz M. Salman, Andrea M. Halsey, Alex C. Conner, Jerome Badaut, Marie Xun Wang, Roslyn M. Bill, Jeffrey J. Iliff, Philip Kitchen
Publikováno v:
Brain-A Journal of Neurology
Brain-A Journal of Neurology, Oxford University Press (OUP), 2021, ⟨10.1093/brain/awab311/6367770⟩
Brain-A Journal of Neurology, Oxford University Press (OUP), 2021, ⟨10.1093/brain/awab311/6367770⟩
Aquaporin channels facilitate bidirectional water flow in all cells and tissues. AQP4 is highly expressed in astrocytes. In the CNS, it is enriched in astrocyte endfeet, at synapses, and at the glia limitans, where it mediates water exchange across t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d68443c052ca0c071a44d1007959b02d
https://hal-cnrs.archives-ouvertes.fr/hal-03366666
https://hal-cnrs.archives-ouvertes.fr/hal-03366666
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2021
Aquaporins and aquaglyceroporins are membrane channels that allow the permeation of water and certain other small solutes across the cell membrane, or in the case of AQP6, AQP11 and AQP12A, intracellular membranes, such as vesicles and the endoplasmi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e76e266615f0e121f4d9d8a9ac5de679
https://doi.org/10.2218/gtopdb/f119/2021.3
https://doi.org/10.2218/gtopdb/f119/2021.3
Autor:
Hans J. Vogel, Alex C. Conner, Roslyn M. Bill, Hiroaki Ishida, Philip Kitchen, Justin A. MacDonald
Aquaporin 4 (AQP4) is a water transporting, transmembrane channel protein that has important regulatory roles in maintaining cellular water homeostasis. Several other AQP proteins exhibit calmodulin (CaM)-binding properties, and CaM has recently been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0808f476946f129a00899c2bc7eb477b
https://doi.org/10.1101/2021.06.29.450403
https://doi.org/10.1101/2021.06.29.450403
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2020
Aquaporins and aquaglyceroporins are membrane channels that allow the permeation of water and certain other small solutes across the cell membrane, or in the case of AQP6, AQP11 and AQP12A, intracellular membranes, such as vesicles and the endoplasmi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67a958dd5917c80a12e73e4e7f9e04bf
https://doi.org/10.2218/gtopdb/f119/2020.4
https://doi.org/10.2218/gtopdb/f119/2020.4
Autor:
Charlotte Clarke-Bland, Andrea M. Halsey, Hiroaki Ishida, Matthew T. Conner, Alex C. Conner, Philip Kitchen, Ann Logan, Susanna Törnroth-Horsefield, Julie Winkel Missel, Mootaz M. Salman, Pontus Gourdon, Sharif Almutiri, Stefan Kreida, Hans J. Vogel, Zubair Ahmed, Roslyn M. Bill, Tamim Al-Jubair, Justin A. MacDonald
Publikováno v:
Kitchen, P, Salman, M M, Halsey, A M, Clarke-Bland, C, MacDonald, J A, Ishida, H, Vogel, H J, Almutiri, S, Logan, A, Kreida, S, Al-Jubair, T, Winkel Missel, J, Gourdon, P, Törnroth-Horsefield, S, Conner, M T, Ahmed, Z, Conner, A C & Bill, R M 2020, ' Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema ', Cell, vol. 181, no. 4, pp. 784-799 . https://doi.org/10.1016/j.cell.2020.03.037
Cell
Cell
Summary Swelling of the brain or spinal cord (CNS edema) affects millions of people every year. All potential pharmacological interventions have failed in clinical trials, meaning that symptom management is the only treatment option. The water channe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c988cdd7f5d6e5a62e364529ce9b2792
https://curis.ku.dk/ws/files/244572535/OA_Targeting_Aquaporin_4_Subcellular_Localization_to_Treat_Central_Nervous_System_Edema.pdf
https://curis.ku.dk/ws/files/244572535/OA_Targeting_Aquaporin_4_Subcellular_Localization_to_Treat_Central_Nervous_System_Edema.pdf