Výsledky vyhledávání - "Alex C. A. Kluppel"

Myocardial infarction does not further impair renal damage in 5/6 nephrectomized rats

Autor: Ying Xu, Robert H. Henning, Willemijn A.K.M. Windt, Richard P. E. van Dokkum, Dick de Zeeuw, Alex C. A. Kluppel

Publikováno v: Nephrology Dialysis Transplantation, 23(10), 3103-3110. Oxford University Press

Background. Recent observational studies show that reduced renal function is an independent risk factor for the development of cardiovascular disease. Previously, we reported that myocardial infarction (MI) indeed enhanced mild renal function decline

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e872820eab6d16aac59322bc81d9dd64
https://doi.org/10.1093/ndt/gfn233

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Urine collection in the freely moving rat

Autor: de Paul Jong, Alex C. A. Kluppel, Frits Moolenaar, Dirk K. F. Meijer, M Haas, de Dick Zeeuw

Publikováno v: Journal of Pharmacological and Toxicological Methods, 38(1), 47-51

Studies on short-term renal responses to (pharmacological) intervention require accurate and multiple collection of urine samples. Several invasive techniques have been described for frequent urine collection of the conscious rat, each having their o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca054481534d69ac6c2b8f20f1de5eb
https://hdl.handle.net/11370/9d87697b-df7d-400a-b92a-153c31ad241e

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Renal endothelial function and blood flow predict the individual susceptibility to adriamycin-induced renal damage

Autor: Richard P. E. van Dokkum, Peter Ochodnicky, Alex C. A. Kluppel, Hendrik Buikema, Robert H. Henning, Dick de Zeeuw, Marjolein van Wattum

Publikováno v: Nephrology Dialysis Transplantation, 24(2), 413-420. Oxford University Press
Nephrology, dialysis, transplantation, 24(2), 413-420. Oxford University Press

Background. Susceptibility to renal injury varies among individuals. Previously, we found that individual endothelial function of healthy renal arteries in vitro predicted severity of renal damage after 5/6 nephrectomy. Here we hypothesized that indi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e283311d0702c4dee207c88686f5df5
https://research.rug.nl/en/publications/a5d91209-475f-4895-9bc6-252a6e92817a

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Early, but not late therapy with a vasopressin V1a-antagonist ameliorates the development of renal damage after 5/6 nephrectomy

Autor: Atsua Tahara, Richard P. E. van Dokkum, Dick de Zeeuw, Willemijn A.K.M. Windt, Robert H. Henning, Alex C. A. Kluppel

Publikováno v: Journal of the Renin-Angiotensin-Aldosterone System, 7(4), 217-224
Journal of the Renin-Angiotensin-Aldosterone System, Vol 7 (2006)

Introduction. Vasopressin, mainly through the V1a-receptor, is thought to be a major player in the maintenance of hyperfiltration. Its inhibition could therefore lead to a decrease in progression of chronic renal failure.To this end, the effect of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f726a0bdd3153d2ec292ea3f2605b8b
https://research.rug.nl/en/publications/5cd2a824-e7a2-4de0-bbb9-89aad76de940

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Renal damage after myocardial infarction is prevented by renin-angiotensin-aldosterone-system intervention

Autor: Stefan Schäfer, Dick de Zeeuw, Hans L. Hillege, Willemijn A.K.M. Windt, Robert H. Henning, Wouter B.A. Eijkelkamp, Richard P. E. van Dokkum, Alex C. A. Kluppel, Pieter A. de Graeff

Publikováno v: Journal of the American Society of Nephrology, 17(11), 3059-3066. AMER SOC NEPHROLOGY

Recently, it was shown that myocardial infarction aggravates preexistent mild renal damage that is elicited by unilateral nephrectomy in rats. The mechanism behind this cardiorenal interaction likely involves the renin-angiotensin-aldosterone-system

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d210f2b7b8b3d7fda49ef3192c41b405
https://pubmed.ncbi.nlm.nih.gov/17005935

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Myocardial infarction enhances progressive renal damage in an experimental model for cardio-renal interaction

Autor: Wouter B.A. Eijkelkamp, Pieter A. de Graeff, Dirk J. van Veldhuisen, Harry van Goor, Dick de Zeeuw, Marin Citgez, Robert H. Henning, Willemijn A.K.M. Windt, Richard P. E. van Dokkum, Alex C. A. Kluppel

Publikováno v: Journal of the American Society of Nephrology, 15(12), 3103-3110. AMER SOC NEPHROLOGY

Studied were the effects of myocardial infarction (MI) on mild renal function loss in unilateral nephrectomized (UnX) rats. UnX was performed, followed after 1 wk by a variable MI (UnX + MI; n = 24). Rats with only UnX (n = 15) or MI (n = 9) and doub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceda6cd4085f3b10b632ed75d7e029b4
https://pubmed.ncbi.nlm.nih.gov/15579513

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Drug-targeting to the kidney: renal delivery and degradation of a naproxen-lysozyme conjugate in vivo

Autor: Paul E. de Jong, Dick de Zeeuw, Frits Moolenaar, Ellen S. Wartna, M Haas, Alex C. A. Kluppel, Dirk K. F. Meijer

Publikováno v: Kidney International, 52(6), 1693-1699. ELSEVIER SCIENCE INC

Drug-targeting to the kidney: Renal delivery and degradation of a naproxen-lysozyme conjugate in vivo. A renal-specific controlled release of an active drug may enable a reduction of the required dose and may provide a reduction of extra-renal toxici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a58c40664c58c3459c3112e41cac6d6
https://pubmed.ncbi.nlm.nih.gov/9407519

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Determination of dopaminergic prodrugs by high-performance liquid chromatography followed by post-column ion-pair extraction

Autor: Dick de Zeeuw, M Haas, Dirk K. F. Meijer, Durk Dijkstra, Frits Moolenaar, Alex C. A. Kluppel

Publikováno v: Journal of Chromatography B, 693(2), 484-488
University of Groningen

One possibility to optimize the therapeutic application of dopaminergic compounds with a catechol function is the reversible protection of this moiety using a prodrug approach. Important features in this respect are a proper chemical stability in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06840edf41c41293f88c9d8aec79320e
https://pubmed.ncbi.nlm.nih.gov/9210456

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