Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Alex Brackbill"'
Autor:
Stefan W. Metz, Ashlie Thomas, Alex Brackbill, John Forsberg, Michael J. Miley, Cesar A. Lopez, Helen M. Lazear, Shaomin Tian, Aravinda M. de Silva
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
Many human antibodies that neutralize Zika virus recognize quaternary epitopes on the envelope (E) protein. Here, Metz et al. engineer stable recombinant homodimers of Zika virus E protein and show that it induces neutralizing antibodies in mice that
Externí odkaz:
https://doaj.org/article/e36de0074bf54f54a8a6e3c49a2d1323
Autor:
Stefan W. Metz, Emily N. Gallichotte, Alex Brackbill, Lakshmanane Premkumar, Michael J. Miley, Ralph Baric, Aravinda M. de Silva
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract Zika virus (ZIKV) and the 4 dengue virus (DENV) serotypes are mosquito-borne Flaviviruses that are associated with severe neuronal and hemorrhagic syndromes. The mature flavivirus infectious virion has 90 envelope (E) protein homo-dimers tha
Externí odkaz:
https://doaj.org/article/124462baa03a44d88e19b793bcc298bf
Autor:
Stefan W Metz, Ashlie Thomas, Alex Brackbill, Yi Xianwen, Michele Stone, Katie Horvath, Michael J Miley, Chris Luft, Joseph M DeSimone, Shaomin Tian, Aravinda M de Silva
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 9, p e0006793 (2018)
Dengue virus (DENV) is the causative agent of dengue fever and dengue hemorrhagic shock syndrome. Dengue vaccine development is challenging because of the need to induce protection against four antigenically distinct DENV serotypes. Recent studies in
Externí odkaz:
https://doaj.org/article/a436f753500142288d12edd9e04f8822
Autor:
Aravinda M. de Silva, Molly Paul, Shaomin Tian, J. Christopher Luft, Michael J. Miley, Jason E. Coffman, Joseph M. DeSimone, Alex Brackbill, Stefan W. Metz
Publikováno v:
Bioconjugate Chemistry. 29:1544-1552
The dengue virus (DENV) causes over 350 million infections, resulting in ∼25,000 deaths per year globally. An effective dengue vaccine requires generation of strong and balanced neutralizing antibodies against all four antigenically distinct seroty
Autor:
Ashlie Thomas, Michael J. Miley, Aravinda M. de Silva, Cesar A. Lopez, John Forsberg, Alex Brackbill, Helen M. Lazear, Stefan W. Metz, Shaomin Tian
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
The current leading Zika vaccine candidates in clinical testing are based on live or killed virus platforms, which have safety issues, especially in pregnant women. Zika subunit vaccines, however, have shown poor performance in preclinical studies, m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3871d8e6076ce7c2e7f730a8d1187fa3
Autor:
Ralph S. Baric, Alex Brackbill, Stefan W. Metz, Emily N. Gallichotte, Lakshmanane Premkumar, Aravinda M. de Silva, Michael J. Miley
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Zika virus (ZIKV) and the 4 dengue virus (DENV) serotypes are mosquito-borne Flaviviruses that are associated with severe neuronal and hemorrhagic syndromes. The mature flavivirus infectious virion has 90 envelope (E) protein homo-dimers that pack ti
Autor:
Michele Stone, Ashlie Thomas, Aravinda M. de Silva, Katie Horvath, Chris Luft, Stefan W. Metz, Alex Brackbill, Yi Xianwen, Shaomin Tian, Joseph M. DeSimone, Michael J. Miley
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 9, p e0006793 (2018)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
Dengue virus (DENV) is the causative agent of dengue fever and dengue hemorrhagic shock syndrome. Dengue vaccine development is challenging because of the need to induce protection against four antigenically distinct DENV serotypes. Recent studies in