Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Alex Blokhuis"'
RNA diversification by a self-reproducing ribozyme revealed by deep sequencing and kinetic modelling
Autor:
Sandeep Ameta, Camille N Lambert, Alex Blokhuis, Cyrille Jeancolas, Thomas Alline, Andrew D. Griffiths, Sandeep Krishna, Mykhailo Vybornyi, Philippe Nghe, Yoshiya J. Matsubara
Publikováno v:
Chemical Communications, 57(61), 7517-7520. ROYAL SOC CHEMISTRY
Chemical Communications (Cambridge, England)
Chemical Communications (Cambridge, England)
We demonstrate that a recombinase ribozyme achieves multiple functions in the same reaction network: self-reproduction, iterative elongation and circularization of other RNAs, leading to synthesis of diverse products predicted by a kinetic model. Thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eefbf9689632270e6facb197771c13b
https://doi.org/10.1039/d1cc02290c
https://doi.org/10.1039/d1cc02290c
Publikováno v:
Chemical Communications. 55:2090-2093
We report empirically and theoretically that multiple prebiotic minerals can selectively accumulate longer RNAs, with selectivity enhanced at higher temperatures. We further demonstrate that surfaces can be combined with a catalytic RNA to form longe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eb3d787298ee3af553202a9b83ba107
https://doi.org/10.1039/c8cc10319d
https://doi.org/10.1039/c8cc10319d
Autor:
Omer Markovitch, Ruth Dorel, Eise R. Nijboer, Lukas Pfeifer, Alex Blokhuis, Gregory B. Boursalian, Ben L. Feringa
Publikováno v:
Journal of the American Chemical Society, 142(39), 16868-16876. AMER CHEMICAL SOC
Unidirectional molecular rotation based on alternating photochemical and thermal isomerizations of overcrowded alkenes is well established, but rotary cycles based purely on photochemical isomerizations are rare. Herein we report three new second-gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bdb5c2bb47795dc1a70955af8d14314
https://research.rug.nl/en/publications/0f69b1bf-0286-4b55-bf63-47e942bfff51
https://research.rug.nl/en/publications/0f69b1bf-0286-4b55-bf63-47e942bfff51
Autocatalysis is an essential property for theories of abiogenesis and chemical evolution. However, the different formalisms proposed so far seemingly address different forms of autocatalysis and it remains unclear whether all of them have been captu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75ce826829f1f63f920f72061252870f
https://doi.org/10.26434/chemrxiv.12317273.v2
https://doi.org/10.26434/chemrxiv.12317273.v2
We extend a recently introduced framework for transient compartmentalization of replicators with selection dynamics, by including the effect of mutations and noise in such systems. In the presence of mutations, functional replicators (ribozymes) are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9def244b6638fc6a99b4d3a685cfa449
https://doi.org/10.1101/521211
https://doi.org/10.1101/521211
Publikováno v:
Journal of Theoretical Biology
Journal of Theoretical Biology, Elsevier, 2020, 487, pp.110110. ⟨10.1016/j.jtbi.2019.110110⟩
Journal of Theoretical Biology, Elsevier, 2020, 487, pp.110110. ⟨10.1016/j.jtbi.2019.110110⟩
Can prelife proceed without cell division? A recently proposed mechanism suggests that transient compartmentalization could have preceded cell division in prebiotic scenarios. Here, we study transient compartmentalization dynamics in the presence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a479b7123885424a5cce8ff1cfb341d
http://arxiv.org/abs/1901.04753
http://arxiv.org/abs/1901.04753
Publikováno v:
Journal of Chemical Physics
Journal of Chemical Physics, American Institute of Physics, 2018, 148 (14), pp.144902. ⟨10.1063/1.5022697⟩
Journal of Chemical Physics, American Institute of Physics, 2018, 148 (14), pp.144902. ⟨10.1063/1.5022697⟩
Kinetic theory and thermodynamics of reaction networks are extended to the out-of-equilibrium dynamics of continuous-flow stirred tank reactors (CSTR) and serial transfers. On the basis of their stoichiometry matrix, the conservation laws and the cyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::872b49e5f2bd80176ea628f8fea5ee7e
https://pubmed.ncbi.nlm.nih.gov/29655349
https://pubmed.ncbi.nlm.nih.gov/29655349
Publikováno v:
Physical Review Letters
Physical Review Letters, American Physical Society, 2018, 120 (15), ⟨10.1103/PhysRevLett.120.158101⟩
Physical Review Letters, American Physical Society, 2018, 120 (15), ⟨10.1103/PhysRevLett.120.158101⟩
Transient compartments have been recently shown to be able to maintain functional replicators in the context of prebiotic studies. Motivated by this experiment, we show that a broad class of selection dynamics is able to achieve this goal. We identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be0da73661c9fbaad63225a6ec9663f5
https://hal.archives-ouvertes.fr/hal-02371255
https://hal.archives-ouvertes.fr/hal-02371255
Autor:
Alex Blokhuis, David Lacoste
We describe the kinetics and thermodynamics of copolymers undergoing recombination reactions, which are important for prebiotic chemistry. We use two approaches: the first one, based on chemical rate equations and the mass-action law describes the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2526edd859164deabc81edfe205b5116
Publikováno v:
Physical review letters. 116(13)
We experimentally investigate active motion of spherical Janus colloidal particles in a viscoelastic fluid. Self-propulsion is achieved by a local concentration gradient of a critical polymer mixture which is imposed by laser illumination. Even in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c1598591870a77a70124490f15557c1
https://pubmed.ncbi.nlm.nih.gov/27082004
https://pubmed.ncbi.nlm.nih.gov/27082004