Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Alex Berndt"'
Autor:
Maren Heimhalt, Alex Berndt, Jane Wagstaff, Madhanagopal Anandapadamanaban, Olga Perisic, Sarah Maslen, Stephen McLaughlin, Conny Wing-Heng Yu, Glenn R Masson, Andreas Boland, Xiaodan Ni, Keitaro Yamashita, Garib N Murshudov, Mark Skehel, Stefan M Freund, Roger L Williams
Publikováno v:
eLife, Vol 10 (2021)
The mTORC1 kinase complex regulates cell growth, proliferation, and survival. Because mis-regulation of DEPTOR, an endogenous mTORC1 inhibitor, is associated with some cancers, we reconstituted mTORC1 with DEPTOR to understand its function. We find t
Externí odkaz:
https://doaj.org/article/f3e3156092d447fd9fa28ea08dad4816
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
The target of rapamycin (Tor) is a Ser/Thr protein kinase that regulates a wide range of anabolic and catabolic processes. Here the authors describe a sub-nanometer cryo-EM structure of a yeast Tor–Lst8 complex and propose an overall topology that
Externí odkaz:
https://doaj.org/article/495475276f274418a28c2305a92b7244
Autor:
Nathalie Hoang, Erik Schleicher, Sylwia Kacprzak, Jean-Pierre Bouly, Marie Picot, William Wu, Alex Berndt, Eva Wolf, Robert Bittl, Margaret Ahmad
Publikováno v:
PLoS Biology, Vol 6, Iss 8 (2008)
Externí odkaz:
https://doaj.org/article/fa4da5ca35bc4eb68300e46455cf7e4c
Autor:
Madhanagopal Anandapadamanaban, Andreas Boland, Alex Berndt, Olga Perisic, Xiaodan Ni, Stefan M.V. Freund, Jane L. Wagstaff, Roger L. Williams, Sarah L. Maslen, Stephen H. McLaughlin, Keitaro Yamashita, Conny Wing-Heng Yu, Mark Skehel, Maren Heimhalt, Garib N. Murshudov, Glenn R. Masson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c63a7d4c77d781be24fc078b87ff7f22
https://doi.org/10.7554/elife.68799.sa2
https://doi.org/10.7554/elife.68799.sa2
Autor:
Alex Berndt, Madhanagopal Anandapadamanaban, Keitaro Yamashita, Sarah L. Maslen, Mark Skehel, Glenn R. Masson, Stefan M.V. Freund, Maren Heimhalt, Garib N. Murshudov, Roger L. Williams, Olga Perisic, Conny Wing-Heng Yu, Xiaodan Ni, Jane L. Wagstaff, Stephen H. McLaughlin, Andreas Boland
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
mTORC1 is a kinase complex regulating cell growth, proliferation and survival. Because mis-regulation of DEPTOR, an endogenous mTORC1 inhibitor, is associated with some cancers, we reconstituted mTORC1 with DEPTOR to understand its function. We find
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb36120c04dfaa3fc5886b70680a712c
https://doi.org/10.1101/2021.04.28.441853
https://doi.org/10.1101/2021.04.28.441853
Autor:
Alberto Massarotti, Tracey Pirali, Silvio Aprile, Clarissa Landoni, Roger L. Williams, Valentina Mercalli, Alessia Griglio, Rangel L. Silva, Carlo Cosimo Campa, Jean Piero Margaria, Alex Berndt, Elisa Ciraolo, Emilio Hirsch, Marta Serafini, Giovanni Sorba, Giorgio Grosa, Gian Cesare Tron
Publikováno v:
'ChemMedChem ', vol: 12, pages: 1542-1554 (2017)
Chemmedchem
Chemmedchem
Activation of the phosphoinositide 3‐kinase (PI3K) pathway is a key signaling event in cancer, inflammation, and other proliferative diseases. PI3K inhibitors are already approved for some specific clinical indications, but their systemic on‐targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c8362b87328db7cdcf3eba819644e7
https://doi.org/10.1002/cmdc.201700340
https://doi.org/10.1002/cmdc.201700340
Autor:
Balaji Santhanam, Kacper B. Rogala, David M. Sabatini, Alex Berndt, Roger L. Williams, Glenn R. Masson, Olga Perisic, Christopher M. Johnson, Madhanagopal Anandapadamanaban, Jonathan Kaufman
Publikováno v:
PMC
Mastering regulation The mechanistic target of rapamycin complex 1 (mTORC1) is known as the master kinase, acknowledging its key role in integrating multiple signals to regulate cell growth. When nutrients are abundant, heterodimers of Rag, a class o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebde6578d1ef8a73da432ecb6f2b6642
https://pubmed.ncbi.nlm.nih.gov/33010258
https://pubmed.ncbi.nlm.nih.gov/33010258
Autor:
Alex Berndt, David M. Sabatini, Glenn R. Masson, Madhan Anandapadamanaban, Christopher M. Johnson, Roger L. Williams, Jonathan Kaufman, Olga Perisic, Stephen H. McLaughlin
Publikováno v:
Molecular Cancer Research. 18:IA10-IA10
Eukaryotic cells coordinate growth with the availability of nutrients through the protein kinase complex mTORC1, which is part of a pathway that is often upregulated in cancer. The mTORC1 complex is activated by association with two types of GTPases,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::844f02a36fdd1561612111c065134afe
https://doi.org/10.1158/1557-3125.pi3k-mtor18-ia10
https://doi.org/10.1158/1557-3125.pi3k-mtor18-ia10
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
The target of rapamycin (Tor) is a Ser/Thr protein kinase that regulates a range of anabolic and catabolic processes. Tor is present in two complexes, TORC1 and TORC2, in which the Tor–Lst8 heterodimer forms a common sub-complex. We have determined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd446dea7d4d44b4d5c33c7981faff59
https://doi.org/10.1038/ncomms11016
https://doi.org/10.1038/ncomms11016
Publikováno v:
Oncogene
Somatic missense mutations in PIK3CA, which encodes the p110α catalytic subunit of phosphoinositide 3-kinases (PI3Ks), occur frequently in human cancers. Activating mutations spread across multiple domains, some of which are located at inhibitory co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::103fd83243441837858a9decd1b0df50
https://doi.org/10.1038/onc.2011.532
https://doi.org/10.1038/onc.2011.532