The adaptive immune response to Trichuris in wild versus laboratory mice: An established model system in context.

Autor: Iris Mair, Jonathan Fenn, Andrew Wolfenden, Ann E Lowe, Alex Bennett, Andrew Muir, Jacob Thompson, Olive Dieumerci, Larisa Logunova, Susanne Shultz, Janette E Bradley, Kathryn J Else

Publikováno v: PLoS Pathogens, Vol 20, Iss 4, p e1012119 (2024)

Laboratory model organisms have provided a window into how the immune system functions. An increasing body of evidence, however, suggests that the immune responses of naive laboratory animals may differ substantially to those of their wild counterpar

Externí odkaz: https://doaj.org/article/4e1bbbd0da5f4873a3dc7c3561733d58

3299 Dynamic Afterload Cardiac Microtissue Model To Examine Molecular Pathways of Heart Failure

Autor: Abhinay Ramachandran, Carissa Livingston, Elise Corbin, Alexia Vite, Alex Bennett, Kenneth Margulies

Publikováno v: Journal of Clinical and Translational Science, Vol 3, Pp 9-9 (2019)

OBJECTIVES/SPECIFIC AIMS: This project aims to determine the key molecular pathways that link increased myocardial wall stress to cardiomyocyte hypertrophy and subsequent heart failure. We will use a cardiac microtissue (CMT) model with dynamically t

Externí odkaz: https://doaj.org/article/f1e47140cdaf4bae9124cb86e292d54d

The wild mouse bone marrow has a unique myeloid and lymphoid composition and phenotype

Autor: Andrew Muir, Alex Bennett, Hannah Smith, Larisa Logunova, Andrew Wolfenden, Jonathan Fenn, Ann E Lowe, Andy Brass, John R Grainger, Joanne E Konkel, Janette E Bradley, Iris Mair, Kathryn J Else

Publikováno v: Discovery Immunology. 2

The murine bone marrow has a central role in immune function and health as the primary source of leukocytes in adult mice. Laboratory mice provide a human-homologous, genetically manipulable and reproducible model that has enabled an immeasurable vol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::178b6e95d06c8f094e5299c48b72d178
https://doi.org/10.1093/discim/kyad005

FUNCTIONAL CLASS AND PHYSICIAN-PERCEIVED SEVERITY ARE SIMILAR IN TREATED AND UNTREATED PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION: A REAL-WORLD SURVEY

Autor: Kelly Chin, Gina Nelson, Dave Mottola, Mark Small, Robert Roscigno, Vallerie V. McLaughlin, Lawrence S. Zisman, Alex Bennett, Roham T. Zamanian

Publikováno v: Chest. 160:A2258-A2260

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::102f6b2b829ffceda7d6bdbc11b36573
https://doi.org/10.1016/j.chest.2021.07.1985

A lesson from the wild: The natural state of eosinophils is Ly6Ghi

Autor: Hannah Smith, Ann Lowe, Jonathan Fenn, Janette E. Bradley, Kathryn J. Else, Alex Bennett, Andrew Muir, Andrew Wolfenden, Iris Mair

Publikováno v: Mair, I, Wolfenden, A, Lowe, A E, Bennett, A, Muir, A, Smith, H, Fenn, J, Bradley, J E & Else, K J 2021, ' A lesson from the wild: The natural state of eosinophils is Ly6Ghi ', Immunology, vol. 164, no. 4, pp. 766-776 . https://doi.org/10.1111/imm.13413
Immunology

With a long history of promoting pathological inflammation, eosinophils are now emerging as important regulatory cells. Yet, findings from controlled laboratory experiments so far lack translation to animals, including humans, in their natural enviro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43ffe7db3d122262e802b01dfa7a58d7
https://www.research.manchester.ac.uk/portal/en/publications/a-lesson-from-the-wild-the-natural-state-of-eosinophils-is-ly6ghi(f1c18248-2d75-47f1-a40b-c40393277131).html