Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Alex B. Kleinpeter"'
Publikováno v:
Viruses, Vol 15, Iss 10, p 2063 (2023)
The Influenza A virus is a continuous threat to public health that causes yearly epidemics with the ever-present threat of the virus becoming the next pandemic. Due to increasing levels of resistance, several of our previously used antivirals have be
Externí odkaz:
https://doaj.org/article/8df904fcec104916bf1636350744aba9
Autor:
Luiza Mendonça, Dapeng Sun, Jiying Ning, Jiwei Liu, Abhay Kotecha, Mateusz Olek, Thomas Frosio, Xiaofeng Fu, Benjamin A. Himes, Alex B. Kleinpeter, Eric O. Freed, Jing Zhou, Christopher Aiken, Peijun Zhang
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Mendonça et al. determine the structures of both in vitro assemblies of the HIV structural precursor protein Gag and Gag viral-like particles (VLPs) to 4.2 Å and 4.5 Å resolutions, using cryo-electron tomography and subtomogram averaging. This stu
Externí odkaz:
https://doaj.org/article/9ab2d7c26554447ba2a91fac3949925b
Autor:
Alex B. Kleinpeter, Eric O. Freed
Publikováno v:
Viruses, Vol 12, Iss 9, p 940 (2020)
Since the emergence of HIV and AIDS in the early 1980s, the development of safe and effective therapies has accompanied a massive increase in our understanding of the fundamental processes that drive HIV biology. As basic HIV research has informed th
Externí odkaz:
https://doaj.org/article/ed45f22dd7544b0a8e49ba0061513fd4
Autor:
Adolfo Saiardi, Mariia Novikova, Alex B. Kleinpeter, K. M. Rifat Faysal, Leo Kiss, Leo C. James, Eric O. Freed, Zunlong Ke, Bilal Ahsan, Nadine Renner, Miranda S. C. Wilson, Till Böcking, John A. G. Briggs, Donna L. Mallery
Publikováno v:
Science Advances
HIV virion assembly begins with the construction of an immature lattice consisting of Gag hexamers. Upon virion release, protease-mediated Gag cleavage leads to a maturation event in which the immature lattice disassembles and the mature capsid assem
Autor:
Alex B. Kleinpeter, Eric O. Freed
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
A large number of human immunodeficiency virus 1 (HIV-1) integrase (IN) alterations, referred to as class II substitutions, exhibit pleiotropic effects during virus replication. However, the underlying mechanism for the class II phenotype is not know
Autor:
Alex B. Kleinpeter, Jing Zhou, Jiying Ning, Abhay Kotecha, Dapeng Sun, Thomas Frosio, Xiaofeng Fu, Jiwei Liu, Mateusz Olek, Luiza Mendonça, Peijun Zhang, Christopher Aiken, Benjamin A. Himes, Eric O. Freed
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Gag is the HIV structural precursor protein which is cleaved by viral protease to produce mature infectious viruses. Gag is a polyprotein composed of MA (matrix), CA (capsid), SP1, NC (nucleocapsid), SP2 and p6 domains. SP1, together with the last ei
Autor:
Xiaofeng Fu, Benjamin A. Himes, Peijun Zhang, Mateusz Olek, Dapeng Sun, Jiying Ning, Christopher Aiken, Jing Zhou, Jiwei Liu, Eric O. Freed, Thomas Frosio, Abhay Kotecha, Alex B. Kleinpeter, Luiza Mendonça
Gag is the major HIV-1 structural polyprotein precursor. The Gag SP1 domain with the last residues of CA have been hypothesized to form a six-helix bundle necessary for particle assembly, but this bundle has not been fully resolved. Here, we determin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b37f6ac34f04371108f47ff0fdd97b5f
https://doi.org/10.1101/2020.10.31.363382
https://doi.org/10.1101/2020.10.31.363382
Autor:
Donna L, Mallery, Alex B, Kleinpeter, Nadine, Renner, K M Rifat, Faysal, Mariia, Novikova, Leo, Kiss, Miranda S C, Wilson, Bilal, Ahsan, Zunlong, Ke, John A G, Briggs, Adolfo, Saiardi, Till, Böcking, Eric O, Freed, Leo C, James
Publikováno v:
Science Advances
HIV immature lattice stability affects capsid maturation by altering IP6 packaging.
HIV virion assembly begins with the construction of an immature lattice consisting of Gag hexamers. Upon virion release, protease-mediated Gag cleavage leads to
HIV virion assembly begins with the construction of an immature lattice consisting of Gag hexamers. Upon virion release, protease-mediated Gag cleavage leads to
Publikováno v:
J Biol Chem
A critical role of influenza A virus nonstructural protein 1 (NS1) is to antagonize the host cellular antiviral response. NS1 accomplishes this role through numerous interactions with host proteins, including the cytoplasmic pathogen recognition rece
Autor:
Alex B. Kleinpeter, Chad M. Petit, Alexander S. Jureka, Gabriel Cornilescu, Claudia C. Cornilescu
Publikováno v:
Structure. 23(11):2001-2010
The influenza non-structural protein 1 (NS1) plays a critical role in antagonizing the innate immune response to infection. One interaction that facilitates this function is between NS1 and RIG-I, one of the main sensors of influenza virus infection.