Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Alex B Blair"'
Autor:
Ding Ding, Linda Chen, Lei Zheng, May Tun Saung, Stephen Muth, Kenji Fujiwara, Hao Jing, Brian Herbst, MacKenzie Zarecki, Annie Wu, Elaine Bigelow, Keyu Li, Neolle Jurcak, Alex B Blair, Michael Wichroski, Jordan Blum, Nathan Cheadle, Jennifer Koenitzer
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Radiation therapy (RT) has the potential to enhance the efficacy of immunotherapy, such as checkpoint inhibitors, which has dramatically altered the landscape of treatments for many cancers, but not yet for pancreatic ductal adenocarcinoma
Externí odkaz:
https://doaj.org/article/468e45316311472f8fc837a650b30475
Autor:
Keyu Li, Junke Wang, Rui Zhang, Jiawei Zhou, Birginia Espinoza, Nan Niu, Jianxin Wang, Noelle Jurcak, Noah Rozich, Arsen Osipov, MacKenzie Henderson, Vanessa Funes, Melissa Lyman, Alex B. Blair, Brian Herbst, Mengni He, Jialong Yuan, Diego Trafton, Chunhui Yuan, Michael Wichroski, Xubao Liu, Juan Fu, Lei Zheng
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-6 (2024)
Abstract Due to the challenge for intratumoral administration, innate agonists have not made it beyond preclinical studies for efficacy testing in most tumor types. Pancreatic ductal adenocarcinoma (PDAC) has a hostile tumor microenvironment that ren
Externí odkaz:
https://doaj.org/article/bfd08d1266be4922922c25e98fb0b353
Autor:
Logan R. McNeil, BA, Alex B. Blair, MD, Robert W. Krell, MD, Chunmeng Zhang, MD, Aslam Ejaz, MD, MPH, Vincent P. Groot, MD, PhD, Georgios Gemenetzis, MD, James C. Padussis, MD, Massimo Falconi, MD, Christopher L. Wolfgang, MD, PhD, Matthew J. Weiss, MD, Chandrakanth Are, MD, MBA, Jin He, MD, PhD, Bradley N. Reames, MD, MS
Publikováno v:
Surgery Open Science, Vol 10, Iss , Pp 97-105 (2022)
Background: Recent literature suggests wide variations exist in the international management of locally advanced pancreatic cancer. This study sought to evaluate how geography contributes to variations in management of locally advanced pancreatic can
Externí odkaz:
https://doaj.org/article/411b220dbef84f7aaf33c5c02f42df44
Autor:
Victoria M. Kim, Alex B. Blair, Peter Lauer, Kelly Foley, Xu Che, Kevin Soares, Tao Xia, Stephen T. Muth, Jennifer Kleponis, Todd D. Armstrong, Christopher L. Wolfgang, Elizabeth M. Jaffee, Dirk Brockstedt, Lei Zheng
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-13 (2019)
Abstract Background Immune checkpoint inhibitors are not effective for pancreatic ductal adenocarcinoma (PDAC) as single agents. Vaccine therapy may sensitize PDACs to checkpoint inhibitor treatments. Annexin A2 (ANXA2) is a pro-metastasis protein, p
Externí odkaz:
https://doaj.org/article/54280b372b12429ab75fc9c756155e36
Autor:
May Tun Saung, Stephen Muth, Ding Ding, Dwayne L. Thomas, Alex B. Blair, Takahiro Tsujikawa, Lisa Coussens, Elizabeth M. Jaffee, Lei Zheng
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-11 (2018)
Abstract Background The pancreatic cancer vaccine, GVAX, induces novel lymphoid aggregates in the otherwise immune quiescent pancreatic ductal adenocarcinoma (PDAC). GVAX also upregulates the PD-1/PD-L1 pathway, and a pre-clinical model demonstrated
Externí odkaz:
https://doaj.org/article/67cbbd738fa74cc7b79e195ba66bac18
Autor:
Lei Zheng, Christopher L. Wolfgang, Richard A. Burkhart, Jin He, Lisa M. Coussens, Takahiro Tsujikawa, Elizabeth M. Jaffee, Todd D. Armstrong, Barbara Blouw, Nathalie Lokker, May Tun Saung, Stephen T. Muth, Victoria M. Kim, Alex B. Blair
Supplemental Data: Figure S1: Pathologic representation of hemispleen liver metastases; Figure S2: Treatment schema; Figure S3: Supplemental survival; Figure S4: FACS PD1/PDL1 expression; Figure S5: Myeloid cell FACS; Figure S6: Multiplex IHC of myel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::173c935d5d37b4ac9a455780845662b5
https://doi.org/10.1158/1078-0432.22471740
https://doi.org/10.1158/1078-0432.22471740
Autor:
Lei Zheng, Christopher L. Wolfgang, Richard A. Burkhart, Jin He, Lisa M. Coussens, Takahiro Tsujikawa, Elizabeth M. Jaffee, Todd D. Armstrong, Barbara Blouw, Nathalie Lokker, May Tun Saung, Stephen T. Muth, Victoria M. Kim, Alex B. Blair
Purpose:Myeloid cells are a prominent immunosuppressive component within the stroma of pancreatic ductal adenocarcinoma (PDAC). Previously, targeting myeloid cells has had limited success. Here, we sought to target the myeloid cells through modifying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::696664909a2932d434533b1e4556b1e1
https://doi.org/10.1158/1078-0432.c.6527988.v1
https://doi.org/10.1158/1078-0432.c.6527988.v1
Autor:
William H. Burns, Kelly J. Lafaro, Jin He, Richard A. Burkhart, Matthew J. Weiss, John L. Cameron, Christopher L. Wolfgang, James F. Griffin, Joseph R. Habib, Ross M. Beckman, Alex B. Blair
Publikováno v:
HPB (Oxford)
BACKGROUND: Main-duct (MD) intraductal papillary mucinous neoplasm (IPMN) is associated with malignancy risk. There is a lack of consensus on treatment (partial or total pancreatectomy) when the MD is diffusely involved. We sought to characterize the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda0ab3f3a2d7cb2973ca6795c7f8369
https://doi.org/10.1016/j.hpb.2021.09.013
https://doi.org/10.1016/j.hpb.2021.09.013
Autor:
Jin He, Chandrakanth Are, Matthew J. Weiss, Aslam Ejaz, Robert W. Krell, Vincent P. Groot, Alex B. Blair, James C. Padussis, Georgios Gemenetzis, Bradley N. Reames, Massimo Falconi, Christopher L. Wolfgang
Publikováno v:
Journal of Gastrointestinal Surgery. 25:2562-2571
There is limited high-level evidence to guide locally advanced pancreas cancer (LAPC) management. Recent work shows that surgeons' preferences in LAPC management vary broadly. We sought to examine whether surgeon volume was associated with attitudes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53db7904f15b557e8033270ebb283f59
https://doi.org/10.1007/s11605-021-05034-w
https://doi.org/10.1007/s11605-021-05034-w
Autor:
Hyung Il Seo, Michael D. Kluger, Ho-Seong Han, Wookyeong Song, Wonho Choo, Alex B. Blair, Wooil Kwon, Woo Jung Lee, Taesung Park, Nadine C.M. van Huijgevoort, Goro Honda, Takashi Hatori, Ching-Yao Yang, Shin E. Wang, Hyeong Seok Kim, Ki Byung Song, Satoshi Hirano, Hongbeom Kim, Tsutomu Fujii, Matthias Löhr, Yoo Seok Yoon, Song Cheol Kim, Yasushi Hashimoto, Hiroki Yamaue, Fuyuhiko Motoi, Marc G. Besselink, Masayuki Sho, Marco Del Chiaro, Jin He, Dong Wook Choi, Seong Ho Choi, Chang Moo Kang, Hiroaki Nagano, Hee Chul Yu, Yinmo Yang, Jin Seok Heo, Ippei Matsumoto, Sungyoung Lee, Wenhui Lou, Yi Ming Shyr, Christopher L. Wolfgang, Seungyeoun Lee, Yasuhiro Shimizu, Yuichi Nagakawa, Roberto Salvia, Jin-Young Jang, Jae Do Yang, Sang Geol Kim, Claudio Bassi, Youngmin Han, Sohei Satoi, Gloria H. Su, Jun Chul Chung, Giovanni Marchegiani, Masakazu Yamamoto, Roberto Valente, Seiko Hirono
Publikováno v:
Journal of hepato-biliary-pancreatic sciences. Wiley-Blackwell
Background Although we previously proposed a nomogram to predict malignancy in intraductal papillary mucinous neoplasms (IPMN) and validated it in an external cohort, its application is challenging without data on tumor markers. Moreover, existing no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7416d2eec9524f3c7256a261fe6a1e2d
https://doi.org/10.1002/jhbp.962
https://doi.org/10.1002/jhbp.962