Zobrazeno 1 - 10 of 133 pro vyhledávání: '"Alex B Blair"'
1
Akademický článek
Overcome the challenge for intratumoral injection of STING agonist for pancreatic cancer by systemic administration
Autor: Keyu Li, Junke Wang, Rui Zhang, Jiawei Zhou, Birginia Espinoza, Nan Niu, Jianxin Wang, Noelle Jurcak, Noah Rozich, Arsen Osipov, MacKenzie Henderson, Vanessa Funes, Melissa Lyman, Alex B. Blair, Brian Herbst, Mengni He, Jialong Yuan, Diego Trafton, Chunhui Yuan, Michael Wichroski, Xubao Liu, Juan Fu, Lei Zheng
Publikováno v: Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-6 (2024)
Abstract Due to the challenge for intratumoral administration, innate agonists have not made it beyond preclinical studies for efficacy testing in most tumor types. Pancreatic ductal adenocarcinoma (PDAC) has a hostile tumor microenvironment that ren
Externí odkaz: https://doaj.org/article/bfd08d1266be4922922c25e98fb0b353
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2
Akademický článek
Geographic variation in attitudes regarding management of locally advanced pancreatic cancer
Autor: Logan R. McNeil, BA, Alex B. Blair, MD, Robert W. Krell, MD, Chunmeng Zhang, MD, Aslam Ejaz, MD, MPH, Vincent P. Groot, MD, PhD, Georgios Gemenetzis, MD, James C. Padussis, MD, Massimo Falconi, MD, Christopher L. Wolfgang, MD, PhD, Matthew J. Weiss, MD, Chandrakanth Are, MD, MBA, Jin He, MD, PhD, Bradley N. Reames, MD, MS
Publikováno v: Surgery Open Science, Vol 10, Iss , Pp 97-105 (2022)
Background: Recent literature suggests wide variations exist in the international management of locally advanced pancreatic cancer. This study sought to evaluate how geography contributes to variations in management of locally advanced pancreatic can
Externí odkaz: https://doaj.org/article/411b220dbef84f7aaf33c5c02f42df44
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3
Akademický článek
Inhibition of focal adhesion kinase enhances antitumor response of radiation therapy in pancreatic cancer through CD8+ T cells
Autor: Arsen Osipov, Alex B. Blair, Juliane Liberto, Jianxin Wang, Keyu Li, Brian Herbst, Yao Xu, Shiqi Li, Nan Niu, Rufiaat Rashid, Ding Ding, Yanan Liu, Zaiqi Wang, Christopher L. Wolfgang, Richard A. Burkhart, Daniel Laheru, Lei Zheng
Publikováno v: Cancer Biology & Medicine, Vol 18, Iss 1, Pp 206-214 (2021)
Objective: Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy, due in large part to its resistance to conventional therapies, including radiotherapy (RT). Despite RT exerting a modest antitumor response, it has also been shown to promote
Externí odkaz: https://doaj.org/article/39e6bd391a9843878fe8179f827b11f3
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4
Akademický článek
A contemporary evidence basis for neoadjuvant chemotherapy in upfront resectable pancreatic adenocarcinoma: a systematic review of the literature
Autor: David P. Stonko, MD, MS, Jin He, MD, PhD, Lei Zheng, MD, PhD, Alex B. Blair, MD
Publikováno v: Journal of Pancreatology, Vol 3, Iss 1, Pp 12-20 (2020)
Abstract. Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor survival. Local control through surgical resection paired with radiotherapy and chemotherapy comprise the primary tenets of treatment. Debate exists regarding the tim
Externí odkaz: https://doaj.org/article/fcd2d234b2864288916afb91a7f0f8b4
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5
Akademický článek
Anti-pancreatic tumor efficacy of a Listeria-based, Annexin A2-targeting immunotherapy in combination with anti-PD-1 antibodies
Autor: Victoria M. Kim, Alex B. Blair, Peter Lauer, Kelly Foley, Xu Che, Kevin Soares, Tao Xia, Stephen T. Muth, Jennifer Kleponis, Todd D. Armstrong, Christopher L. Wolfgang, Elizabeth M. Jaffee, Dirk Brockstedt, Lei Zheng
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-13 (2019)
Abstract Background Immune checkpoint inhibitors are not effective for pancreatic ductal adenocarcinoma (PDAC) as single agents. Vaccine therapy may sensitize PDACs to checkpoint inhibitor treatments. Annexin A2 (ANXA2) is a pro-metastasis protein, p
Externí odkaz: https://doaj.org/article/54280b372b12429ab75fc9c756155e36
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8
Akademický článek
Interrogating the immune-modulating roles of radiation therapy for a rational combination with immune-checkpoint inhibitors in treating pancreatic cancer
Autor: Kenji Fujiwara, Hao Jing, Brian Herbst, MacKenzie Zarecki, Annie Wu, Elaine Bigelow, Keyu Li, Neolle Jurcak, Alex B Blair, Michael Wichroski, Jordan Blum, Nathan Cheadle, Jennifer Koenitzer
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Radiation therapy (RT) has the potential to enhance the efficacy of immunotherapy, such as checkpoint inhibitors, which has dramatically altered the landscape of treatments for many cancers, but not yet for pancreatic ductal adenocarcinoma
Externí odkaz: https://doaj.org/article/468e45316311472f8fc837a650b30475
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9
Akademický článek
Targeting myeloid-inflamed tumor with anti-CSF-1R antibody expands CD137+ effector T-cells in the murine model of pancreatic cancer
Autor: May Tun Saung, Stephen Muth, Ding Ding, Dwayne L. Thomas, Alex B. Blair, Takahiro Tsujikawa, Lisa Coussens, Elizabeth M. Jaffee, Lei Zheng
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-11 (2018)
Abstract Background The pancreatic cancer vaccine, GVAX, induces novel lymphoid aggregates in the otherwise immune quiescent pancreatic ductal adenocarcinoma (PDAC). GVAX also upregulates the PD-1/PD-L1 pathway, and a pre-clinical model demonstrated
Externí odkaz: https://doaj.org/article/67cbbd738fa74cc7b79e195ba66bac18
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