Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Alex B, Burgin"'
Autor:
Lisa Brenan, Aleksandr Andreev, Ofir Cohen, Sasha Pantel, Atanas Kamburov, Davide Cacchiarelli, Nicole S. Persky, Cong Zhu, Mukta Bagul, Eva M. Goetz, Alex B. Burgin, Levi A. Garraway, Gad Getz, Tarjei S. Mikkelsen, Federica Piccioni, David E. Root, Cory M. Johannessen
Publikováno v:
Cell Reports, Vol 17, Iss 4, Pp 1171-1183 (2016)
Tumor-specific genomic information has the potential to guide therapeutic strategies and revolutionize patient treatment. Currently, this approach is limited by an abundance of disease-associated mutants whose biological functions and impacts on ther
Externí odkaz:
https://doaj.org/article/57cdb9a4187d4248b7ec2fc37e170d43
Autor:
Matthew C Clifton, David M Dranow, Alison Leed, Ben Fulroth, James W Fairman, Jan Abendroth, Kateri A Atkins, Ellen Wallace, Dazhong Fan, Guoping Xu, Z J Ni, Doug Daniels, John Van Drie, Guo Wei, Alex B Burgin, Todd R Golub, Brian K Hubbard, Michael H Serrano-Wu
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0125010 (2015)
Crystallization of a maltose-binding protein MCL1 fusion has yielded a robust crystallography platform that generated the first apo MCL1 crystal structure, as well as five ligand-bound structures. The ability to obtain fragment-bound structures advan
Externí odkaz:
https://doaj.org/article/1fecc03a2b9c44169e845be5165ab56e
Autor:
Victor Seguritan, Nelson Alves, Michael Arnoult, Amy Raymond, Don Lorimer, Alex B Burgin, Peter Salamon, Anca M Segall
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 8, p e1002657 (2012)
Phages play critical roles in the survival and pathogenicity of their hosts, via lysogenic conversion factors, and in nutrient redistribution, via cell lysis. Analyses of phage- and viral-encoded genes in environmental samples provide insights into t
Externí odkaz:
https://doaj.org/article/3fcd19c29c714c9c8afaeb6dc4345047
Autor:
David A. Fox, Bruce Carrington, Rachel Davis, Alex Vugler, John Robert Porter, Timothy John Norman, Benjamin P. Cossins, Boris Kroeplien, Fabien Claude Lecomte, David McMillan, Alastair D. G. Lawson, Alex B. Burgin, Tim Bourne, Stephen Edward Rapecki, Tom Ceska, O'connell James Philip, Alison Maloney, Tracy Arakaki
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Tumour necrosis factor (TNF) is a cytokine belonging to a family of trimeric proteins; it has been shown to be a key mediator in autoimmune diseases such as rheumatoid arthritis and Crohn’s disease. While TNF is the target of several successful bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba75e1e459ecf691ae457ba06c464cbc
https://doi.org/10.1038/s41467-019-13616-1
https://doi.org/10.1038/s41467-019-13616-1
Autor:
Wim Versées, Zhenyu Yue, Giambattista Guaitoli, Alex B. Burgin, Christian Johannes Gloeckner, Egon Deyaert, Felix von Zweydorf, Francesco Raimondi, Fabiana Renzi, Pravin Kumar Ankush Jagtap, Arjan Kortholt, Katja Gotthardt, Adam Schaffner, Karsten Boldt, Xianting Li, Iban Ubarretxena-Belandia, Yacob Gomez-Llorente, Donald D. Lorimer, Nebojsa Janjic, Bernd K Gilsbach, Michael Sattler, Marius Ueffing
Publikováno v:
'Proceedings of the National Academy of Sciences of the USA ', vol: 113, pages: E4357-E4366 (2016)
Proceedings of the National Academy of Sciences of the United States of America, 113(30), E4357-E4366. NATL ACAD SCIENCES
Proceedings of the National Academy of Sciences of the United States of America 113(30), E4357-E4366 (2016). doi:10.1073/pnas.1523708113
Proceedings of the National Academy of Sciences of the United States of America, 113(30), E4357-E4366. NATL ACAD SCIENCES
Proceedings of the National Academy of Sciences of the United States of America 113(30), E4357-E4366 (2016). doi:10.1073/pnas.1523708113
Leucine-rich repeat kinase 2 (LRRK2) is a large, multidomain protein containing two catalytic domains: a Ras of complex proteins (Roc) G-domain and a kinase domain. Mutations associated with familial and sporadic Parkinson's disease (PD) have been id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::874400366e144c61561b4b1271088eaa
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:44933
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:44933
Publikováno v:
Cellular Signalling. 26:657-663
Phosphodiesterase-4B (PDE4B) regulates the pro-inflammatory Toll Receptor –Tumor Necrosis Factor α (TNFα) pathway in monocytes, macrophages and microglial cells. As such, it is an important, although under-exploited molecular target for anti-infl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04754749c7bd3794c6466bdc35b7138c
https://doi.org/10.1016/j.cellsig.2013.12.003
https://doi.org/10.1016/j.cellsig.2013.12.003
Autor:
Donald D. Lorimer, Andriy Kryshtafovych, Hartmut Luecke, Torsten Schwede, Rhiju Das, Mark J. van Raaij, Carmela Garcia-Doval, Xiaolei Ma, Patrick M. Bales, Kornelius Zeth, Deborah Fass, Alex B. Burgin, Frank V. Cochran, Marco Biasini, Victor Seguritan, Daniel C. Nelson, Osnat Herzberg, Anca M. Segall, Chen Chen, J. Fernando Bazan, Timothy K. Craig, Forest Rohwer, John Moult
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 82:26-42
For the last two decades, CASP has assessed the state of the art in techniques for protein structure prediction and identified areas which required further development. CASP would not have been possible without the prediction targets provided by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2cfc91e8732a246339929403e2e99a0
https://doi.org/10.1002/prot.24489
https://doi.org/10.1002/prot.24489
Autor:
Pam Witte, Alex B. Burgin, Jan Abendroth, Anca M. Segall, Timothy K. Craig, Forest Rohwer, Robert Edwards, Jeremy A. Frank, Merry Youle, Don Lorimer
Publikováno v:
The ISME Journal
Bacteriophages encode auxiliary metabolic genes that support more efficient phage replication. For example, cyanophages carry several genes to maintain host photosynthesis throughout infection, shuttling the energy and reducing power generated away f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c34ace27527c7675d95632312b688e9
http://europepmc.org/articles/PMC3660681
http://europepmc.org/articles/PMC3660681
Autor:
Ben Butler-Cole, David J. Sherratt, Henrique Ferreira, Rachel Baker, Lidia K. Arciszewska, Alex B. Burgin
The tyrosine family site-specific recombinases XerC and XerD convert dimers of the Escherichia coli chromosome and many natural plasmids to monomers. The heterotetrameric recombination complex contains two molecules of XerC and two of XerD, with each
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7def1a4ddac46d619b8d220ef40dc528
https://doi.org/10.1016/s0022-2836(03)00558-8
https://doi.org/10.1016/s0022-2836(03)00558-8
Autor:
Tarjei S. Mikkelsen, Federica Piccioni, Sasha Pantel, Nicole S. Persky, Eva M. Goetz, Cong Zhu, Alex B. Burgin, Levi A. Garraway, Mukta Bagul, Cory M. Johannessen, Gad Getz, Ofir Cohen, Davide Cacchiarelli, Aleksandr Andreev, Atanas Kamburov, Lisa Brenan, David E. Root
Publikováno v:
Cell Reports, Vol 17, Iss 4, Pp 1171-1183 (2016)
SummaryTumor-specific genomic information has the potential to guide therapeutic strategies and revolutionize patient treatment. Currently, this approach is limited by an abundance of disease-associated mutants whose biological functions and impacts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf8cd95fcbe9784a9454903ce84dbeb8
http://hdl.handle.net/11588/700774
http://hdl.handle.net/11588/700774