Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Alex Azhayev"'
Autor:
Alex Azhayev, Tuomo A. Keinänen, Mervi T. Hyvönen, Elena S. Matyugina, Anastasia L. Khandazhinskaya, Maria I. Kharitonova, Konstantinova Im, Vladimir Barai, Katherine L. Seley-Radtke, Sergey N. Kochetkov, Barbara Z. Eletskaya, Ilja V. Fateev, Alex R. Khomutov
Publikováno v:
Organicbiomolecular chemistry. 19(34)
Nucleoside analogues have long served as key chemotherapeutic drugs for the treatment of viral infections and cancers. Problems associated with the development of drug resistance have led to a search for the design of nucleosides capable of bypassing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ae17770268059e11cd7279ac794e75
https://pubmed.ncbi.nlm.nih.gov/34198312
https://pubmed.ncbi.nlm.nih.gov/34198312
Autor:
Markus Vehniäinen, Markku Syrjänpää, Tuomas Huovinen, Eeva Christine Brockmann, Urpo Lamminmäki, Qi Wang, Hanna Sanmark, Alex Azhayev
Publikováno v:
Protein Engineering, Design and Selection. 26(10):683-693
In directed evolution experiments, a single randomization scheme of an antibody gene does not provide optimal diversity for recognition of all sizes of antigens. In this study, we have expanded the recognition potential of our universal library, term
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2433a59849b3c76858f11309a74342e2
http://juuli.fi/Record/0040044913
http://juuli.fi/Record/0040044913
Autor:
Alexey L Kayushin, Alex Azhayev, Maria Korosteleva, Alexandra Demekhina, Anatoly I. Miroshnikov
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 30:490-502
A phosphoramidite linker unit, based on glycerol backbone and containing a biotin residue attached through a tetraethylene glycol spacer arm, was synthesized. DMTr-Glycidol and tetraethylene glycol were used as starting materials. After conversion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcf4cd54fc82f2bc751efd4e1089c72a
https://doi.org/10.1080/15257770.2011.587702
https://doi.org/10.1080/15257770.2011.587702
Publikováno v:
Tetrahedron. 66:2210-2221
In the presence of aqueous trialkylammonium hydrogen carbonate, the Staudinger reaction leads to the intermediate formation of the corresponding isocyanate, which, in turn, reacts further with a nucleophilic reagent also present in the mixture and re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d2887e6ab979b9d6d0d2d2b3f988025
https://doi.org/10.1016/j.tet.2010.01.017
https://doi.org/10.1016/j.tet.2010.01.017
Autor:
Andrey Yagodkin, Alex Azhayev
Publikováno v:
Arkivoc. 2009:187-197
Universal Linker phosphoramidite was synthesized and employed for conversion of conventional nucleoside bound solid phase into the universal support. The latter was successfully tested in preparation of the 20mer oligonucleotide.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09a9de4d63eb20ff15fc2f020171ee75
https://doi.org/10.3998/ark.5550190.0010.315
https://doi.org/10.3998/ark.5550190.0010.315
Publikováno v:
Bioconjugate Chemistry. 19:1361-1367
The present work demonstrates that the relatively low molecular weight synthetic peptide-oligonucleotide conjugates are capable of stable and selective three-component complex formation with complementary 72-100mer DNA oligonucleotides and a cardiac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47f560573869fa654e8c21b39d3064a9
https://doi.org/10.1021/bc700457y
https://doi.org/10.1021/bc700457y
Autor:
Tiina Laitala-Leinonen, Tuula Tennilä, Ranga N. Parthasarathy, Elena Azhayeva, Anthony J. Janckila, Pirkko Muhonen, H. Kalervo Väänänen, Alex Azhayev
Publikováno v:
Chemistry & Biodiversity. 4:858-873
Short interfering RNA (siRNA) molecules with good gene-silencing properties are needed for drug development based on RNA interference (RNAi). An initial step in RNAi is the activation of the RNA-induced silencing complex RISC, which requires degradat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be618df8b8cea22b21c46c61c7c199ec
https://doi.org/10.1002/cbdv.200790073
https://doi.org/10.1002/cbdv.200790073
Autor:
Kaisa Ketomäki, Harri Lönnberg, Piia Penttinen, Elena Azhayeva, Tuula Tennilä, Unni Tengvall, Alex Azhayev, Seppo Auriola
Publikováno v:
Chemistry & Biodiversity. 1:609-625
The synthesis of disulfide-cross-linked circular oligonucleotides, employing two different approaches, was accomplished. Several circular oligomers, which bear a C(5)-aminoalkyl-tethered thymidine unit, were labeled with photoluminescent europium(III
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebd6d616ff6338f78ee19b42d2a78a7c
https://doi.org/10.1002/cbdv.200490052
https://doi.org/10.1002/cbdv.200490052
Autor:
Alexei L. Kayushin, Alex Azhayev, Anatoly I. Miroshnikov, Timo Mauriala, Seppo Auriola, Maria Korosteleva
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 34:199-206
Trimeric nucleotide building blocks are valuable in synthesis of randomized oligonucleotides. In this study, we have developed HPLC-MS and HPLC-MS/MS methods for quality control of protected trinucleotides. C18 reversed-phase HPLC was used for purity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae26c00b6f57d5457d8decd47c98df0c
https://doi.org/10.1016/j.japna.2003.07.004
https://doi.org/10.1016/j.japna.2003.07.004
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 32:581-590
Covalent post-synthesis or solid-phase conjugation of peptides to oligonucleotides has been reported as a possible method of delivering antisense oligonucleotides into cells. While synthesis strategies for preparing these conjugates have been widely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc970fdf53d7822cd99c457e31150a4
https://doi.org/10.1016/s0731-7085(03)00165-1
https://doi.org/10.1016/s0731-7085(03)00165-1