Quantification of protein abundance and interaction defines a mechanism for operation of the circadian clock

Autor: James S Bagnall, Alex A Koch, Nicola J Smyllie, Nicola Begley, Antony D Adamson, Jennifer L Fribourgh, David G Spiller, Qing-Jun Meng, Carrie L Partch, Korbinian Strimmer, Thomas A House, Michael H Hastings, Andrew SI Loudon

Publikováno v: Koch, A, Bagnall, J, Smyllie, N J, Begley, N, Adamson, A, Fribourgh, J L, Spiller, D, Meng, Q-J, Partch, C L, Strimmer, K, House, T, Hastings, M H & Loudon, A 2022, ' Quantification of protein abundance and interaction defines a mechanism for operation of the circadian clock ', eLife, vol. 11, e73976 . https://doi.org/10.7554/eLife.73976

The mammalian circadian clock exerts control of daily gene expression through cycles of DNA binding. Here, we develop a quantitative model of how a finite pool of BMAL1 protein can regulate thousands of target sites over daily time scales. We used qu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda5ec2b702d72fdf720c555831088b1
https://research.manchester.ac.uk/en/publications/238e144d-a42e-4255-b827-1bca6bd15350

Quantification of circadian interactions and protein abundance defines a mechanism for operational stability of the circadian clock

Autor: Michael H. Hastings, Korbinian Strimmer, Andrew S. I. Loudon, Nicola J. Smyllie, Alex A. Koch, Thomas House, Nicola Begley, Carrie L. Partch, Antony Adamson, David G. Spiller, Qing-Jun Meng, Jennifer L. Fribourgh, James Bagnall

The mammalian circadian clock exerts substantial control of daily gene expression through cycles of DNA binding. Understanding of mechanisms driving the circadian clock is hampered by lack of quantitative data, without which predictive mathematical m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::331ede3812dadd198d35b62e38ea7712
https://doi.org/10.1101/2021.08.27.456017

Electromyographic comparison of the ab-slide and crunch exercises

Autor: Michael Bird, Alex J. Koch, Kate M. Fletcher

Publikováno v: Journal of strength and conditioning research. 20(2)

The purpose of this study was to compare the Ab-Slide with crunch abdominal exercises for electromyographic activity for selected muscles. Forty-five subjects who regularly performed abdominal exercises participated. Subjects completed 5 trials for e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13fe5b5b5ba9113969593d93b673b9f3
https://pubmed.ncbi.nlm.nih.gov/16686576

Urine Specific Gravity and Osmolality Measurements in a College Football Team

Autor: Abbie E Smith, Alex J. Koch, Jerry L. Mayhew, Scott Roberts

Publikováno v: Medicine & Science in Sports & Exercise. 38:S244

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cbd36d66345308ca0cb2d493b726ccc3
https://doi.org/10.1249/00005768-200605001-01948

Associations of Standard Care, Intrathecal Antibiotics, and Antibiotic-Impregnated Catheters With Cerebrospinal Fluid Shunt Infection Organisms and Resistance.

Autor: Sedano, Sabrina¹ (AUTHOR), Kronman, Matthew P^2,3 (AUTHOR) matthew.kronman@seattlechildrens.org, Whitlock, Kathryn B⁴ (AUTHOR), Zhou, Chuan^2,3 (AUTHOR), Coffin, Susan E⁵ (AUTHOR), Hauptman, Jason S^2,6 (AUTHOR), Heller, Evan⁷ (AUTHOR), Mangano, Francesco T⁸ (AUTHOR), Pollack, Ian F⁹ (AUTHOR), Schaffzin, Joshua K¹⁰ (AUTHOR), Thorell, Emily⁷ (AUTHOR), Warf, Benjamin C¹¹ (AUTHOR), Simon, Tamara D^1,12,13 (AUTHOR)

Publikováno v: Journal of the Pediatric Infectious Diseases Society. Sep2023, Vol. 12 Issue 9, p504-512. 9p.