Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Alex A. Gandhi"'
Autor:
Hui Shi, Alex A. Gandhi, Stephanie A. Smith, Qiuyu Wang, Diane Chiang, Srilakshmi Yalavarthi, Ramadan A. Ali, Chao Liu, Gautam Sule, Pei-Suen Tsou, Yu Zuo, Yogendra Kanthi, Evan A. Farkash, Jiandie D. Lin, James H. Morrissey, Jason S. Knight
Publikováno v:
JCI Insight, Vol 6, Iss 17 (2021)
Neutrophil-mediated activation and injury of the endothelium play roles in the pathogenesis of diverse disease states ranging from autoimmunity to cancer to COVID-19. Neutralization of cationic proteins (such as neutrophil extracellular trap–derive
Externí odkaz:
https://doaj.org/article/841d7563afdf4a2684c13199b322ad80
Autor:
Ramadan A. Ali, Alex A. Gandhi, He Meng, Srilakshmi Yalavarthi, Andrew P. Vreede, Shanea K. Estes, Olivia R. Palmer, Paula L. Bockenstedt, David J. Pinsky, Joan M. Greve, Jose A. Diaz, Yogendra Kanthi, Jason S. Knight
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Antiphospholipid syndrome is characterised by increased neutrophil extracellular trap formation (NETosis) and, consequently, increased thrombotic events. Here Ali et al. show that treatment with adenosine receptor agonists suppresses NETosis and veno
Externí odkaz:
https://doaj.org/article/d8ca98b7f1d54784a2dbed7642ccb42a
Autor:
Ramadan A. Ali, Alex A. Gandhi, Lipeng Dai, Julia Weiner, Shanea K. Estes, Srilakshmi Yalavarthi, Kelsey Gockman, Duxin Sun, Jason S. Knight
Publikováno v:
JCI Insight, Vol 6, Iss 3 (2021)
Ginger is known to have antiinflammatory and antioxidative effects and has traditionally been used as an herbal supplement in the treatment of various chronic diseases. Here, we report antineutrophil properties of 6-gingerol, the most abundant bioact
Externí odkaz:
https://doaj.org/article/e0feddd6aa7d428fab958f336fc5bf0f
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2588 (2021)
Antiphospholipid syndrome (APS) is a leading acquired cause of thrombotic events, with a notable tendency to promote thrombosis in vascular beds of all sizes, including both arterial and venous circuits. While pathogenic antiphospholipid antibodies c
Externí odkaz:
https://doaj.org/article/404d9d4aef9c4195bdff82f4b3c0ec75
Autor:
Hui Shi, Ramadan A. Ali, Shanea K. Estes, Jason S. Knight, Doruk Erkan, Alex A. Gandhi, Srilakshmi Yalavarthi, Yu Zuo, Claire K Hoy
Publikováno v:
Arthritis Rheumatol
OBJECTIVES: Defibrotide is a heterogenous mixture of polyanionic oligonucleotides currently approved for treatment of transplant-associated veno-occlusive disease. While defibrotide has a known role in limiting endothelial cell activation, some studi
Autor:
James H. Morrissey, Stephanie A. Smith, Yu Zuo, Chao Liu, Qiuyu Wang, Yogendra Kanthi, Pei-Suen Tsou, Srilakshmi Yalavarthi, Diane Chiang, Jiandie D. Lin, Jason S. Knight, Gautam Sule, Alex A. Gandhi, Evan A. Farkash, Hui Shi, Ramadan A. Ali
Publikováno v:
medRxiv
JCI Insight
JCI Insight
Neutrophil-mediated activation and injury of the endothelium play a role in the pathogenesis of diverse disease states ranging from autoimmunity to cancer to COVID-19. Neutralization of cationic proteins (such as neutrophil extracellular trap/NET-der
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 2588, p 2588 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 2588, p 2588 (2021)
Antiphospholipid syndrome (APS) is a leading acquired cause of thrombotic events, with a notable tendency to promote thrombosis in vascular beds of all sizes, including both arterial and venous circuits. While pathogenic antiphospholipid antibodies c
Autor:
Yu Zuo, Jacqueline A. Madison, Yogendra Kanthi, Hui Shi, Melanie Zuo, Yue Shi, Michael D. Maile, Alyssa Harbaugh, Srilakshmi Yalavarthi, Sherwin Navaz, Kelsey Gockman, Claire K Hoy, Jason S. Knight, Alex A. Gandhi, Jintao Wang, Gautam Sule
Publikováno v:
medRxiv
Objectives Patients with coronavirus disease 19 ( COVID-19 ) are at high risk for fibrin-based occlusion of vascular beds of all sizes. Considering endothelial cell activation has regularly been described as part of the COVID-19 thrombo-inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224471b456e56cf9bfffd57a4322709c
https://europepmc.org/articles/PMC7836141/
https://europepmc.org/articles/PMC7836141/
Autor:
Vinita Yadav, Sean P Lezak, Stephanie A. Smith, Melanie Zuo, Srilakshmi Yalavarthi, Wrenn Woodard, Yu Zuo, Shanea K. Estes, Kelsey Gockman, Jason S. Knight, Hui Shi, Ramadan A. Ali, Jacqueline A. Madison, Yogendra Kanthi, Njira L Lugogo, Jintao Wang, James H. Morrissey, Gautam Sule, Alex A. Gandhi
Publikováno v:
Science Translational Medicine
Patients with COVID-19 are at high risk for thrombotic arterial and venous occlusions. Lung histopathology often reveals fibrin-based blockages in the small blood vessels of patients who succumb to the disease. Antiphospholipid syndrome is an acquire
Autor:
Duxin Sun, Shanea K. Estes, Kelsey Gockman, Jason S. Knight, Ramadan A. Ali, Lipeng Dai, Srilakshmi Yalavarthi, Julia Weiner, Alex A. Gandhi
Publikováno v:
JCI Insight
JCI Insight, Vol 6, Iss 3 (2021)
JCI Insight, Vol 6, Iss 3 (2021)
Ginger is known to have antiinflammatory and antioxidative effects and has traditionally been used as an herbal supplement in the treatment of various chronic diseases. Here, we report antineutrophil properties of 6-gingerol, the most abundant bioact