Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Alex A. Compton"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Omicron emerged following COVID-19 vaccination campaigns, displaced previous SARS-CoV-2 variants of concern worldwide, and gave rise to lineages that continue to spread. Here, we show that Omicron exhibits increased infectivity in primary ad
Externí odkaz:
https://doaj.org/article/9d9e3bf53c4e42d2940807288b7477e3
Autor:
Guoli Shi, Abhilash I. Chiramel, Tiansheng Li, Kin Kui Lai, Adam D. Kenney, Ashley Zani, Adrian C. Eddy, Saliha Majdoul, Lizhi Zhang, Tirhas Dempsey, Paul A. Beare, Swagata Kar, Jonathan W. Yewdell, Sonja M. Best, Jacob S. Yount, Alex A. Compton
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 24 (2022)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in immunocompromised individuals is associated with prolonged virus shedding and evolution of viral variants. Rapamycin and its analogs (rapalogs, including everolimus, temsirolim
Externí odkaz:
https://doaj.org/article/54c02ef4c7e14f2d8fd82a8b248817d9
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT Serine incorporator 5 (Ser5), a transmembrane protein, has recently been identified as a host antiviral factor against human immunodeficiency virus (HIV)-1 and gammaretroviruses like murine leukemia viruses (MLVs). It is counteracted by HIV-
Externí odkaz:
https://doaj.org/article/145e85a9da3e4cb39d56ca6ba3ca394f
Autor:
Yadvinder S. Ahi, Diborah Yimer, Guoli Shi, Saliha Majdoul, Kazi Rahman, Alan Rein, Alex A. Compton
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
ABSTRACT Interferon-induced transmembrane (IFITM) proteins are encoded by many vertebrate species and exhibit antiviral activities against a wide range of viruses. IFITM3, when present in virus-producing cells, reduces the fusion potential of HIV-1 v
Externí odkaz:
https://doaj.org/article/6c0f7bd7082f450ba1ac4916471050db
Publikováno v:
Retrovirology, Vol 14, Iss 1, Pp 1-11 (2017)
Abstract The first responders of human antiviral immunity are components of the intrinsic immune response that reside within each and every one of our cells. This cell-autonomous arsenal consists of nucleic acid sensors and antiviral effectors strate
Externí odkaz:
https://doaj.org/article/53ce77bb20b345e1b0d3c495a494ba4f
Autor:
Kazi Rahman, Charles A Coomer, Saliha Majdoul, Selena Y Ding, Sergi Padilla-Parra, Alex A Compton
Publikováno v:
eLife, Vol 9 (2020)
The interferon-inducible transmembrane (IFITM) proteins belong to the Dispanin/CD225 family and inhibit diverse virus infections. IFITM3 reduces membrane fusion between cells and virions through a poorly characterized mechanism. Mutation of proline-r
Externí odkaz:
https://doaj.org/article/6d61b165ea014362a89fec8e64dae635
SummaryOmicron emerged following COVID-19 vaccination campaigns, displaced previous SARS-CoV-2 variants of concern worldwide, and gave rise to lineages that continue to spread. Here, we show that Omicron exhibits increased infectivity in primary adul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::012356d5a72b0e0f169472e04d78950d
https://doi.org/10.1101/2023.05.06.539698
https://doi.org/10.1101/2023.05.06.539698
Autor:
Kazi Rahman, Siddhartha A.K. Datta, Andrew H. Beaven, Abigail A. Jolley, Alexander J. Sodt, Alex A. Compton
The interferon-induced transmembrane (IFITM) proteins broadly inhibit the entry of diverse pathogenic viruses, including Influenza A virus (IAV), Zika virus, HIV-1, and SARS coronaviruses by inhibiting virus-cell membrane fusion. IFITM3 was previousl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1519336cf9a29db8e97e57964320f222
https://doi.org/10.1101/2022.04.21.488780
https://doi.org/10.1101/2022.04.21.488780
Autor:
Alex A. Compton, Kazi Rahman
Publikováno v:
J Virol
The interferon-induced transmembrane (IFITM) gene family performs multiple functions in immunity, including inhibition of virus entry into cells. The IFITM repertoire varies widely between species and consists of protein-coding genes and pseudogenes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::738ff3a2ae5caedb3c9af66c5567d61e
https://pubmed.ncbi.nlm.nih.gov/34319781
https://pubmed.ncbi.nlm.nih.gov/34319781
Autor:
Guoli Shi, Abhilash I. Chiramel, Tiansheng Li, Kin Kui Lai, Adam D. Kenney, Ashley Zani, Adrian C. Eddy, Saliha Majdoul, Lizhi Zhang, Tirhas Dempsey, Paul A. Beare, Swagata Kar, Jonathan W. Yewdell, Sonja M. Best, Jacob S. Yount, Alex A. Compton
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
Infection by SARS-CoV-2 generally causes mild symptoms but can lead to severe disease and death in certain populations, including the immunocompromised. Drug repurposing efforts are underway to identify compounds that interfere with SARS-CoV-2 replic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681ff4acf303d40082d1e4292bf4daba
https://pubmed.ncbi.nlm.nih.gov/36264642
https://pubmed.ncbi.nlm.nih.gov/36264642