Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Alex A. Compton"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Omicron emerged following COVID-19 vaccination campaigns, displaced previous SARS-CoV-2 variants of concern worldwide, and gave rise to lineages that continue to spread. Here, we show that Omicron exhibits increased infectivity in primary ad
Externí odkaz:
https://doaj.org/article/9d9e3bf53c4e42d2940807288b7477e3
Autor:
Guoli Shi, Abhilash I. Chiramel, Tiansheng Li, Kin Kui Lai, Adam D. Kenney, Ashley Zani, Adrian C. Eddy, Saliha Majdoul, Lizhi Zhang, Tirhas Dempsey, Paul A. Beare, Swagata Kar, Jonathan W. Yewdell, Sonja M. Best, Jacob S. Yount, Alex A. Compton
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 24 (2022)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in immunocompromised individuals is associated with prolonged virus shedding and evolution of viral variants. Rapamycin and its analogs (rapalogs, including everolimus, temsirolim
Externí odkaz:
https://doaj.org/article/54c02ef4c7e14f2d8fd82a8b248817d9
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT Serine incorporator 5 (Ser5), a transmembrane protein, has recently been identified as a host antiviral factor against human immunodeficiency virus (HIV)-1 and gammaretroviruses like murine leukemia viruses (MLVs). It is counteracted by HIV-
Externí odkaz:
https://doaj.org/article/145e85a9da3e4cb39d56ca6ba3ca394f
Autor:
Charles A Coomer, Irene Carlon-Andres, Maro Iliopoulou, Michael L Dustin, Ewoud B Compeer, Alex A Compton, Sergi Padilla-Parra
Publikováno v:
PLoS Pathogens, Vol 17, Iss 5, p e1009584 (2021)
[This corrects the article DOI: 10.1371/journal.ppat.1008359.].
Externí odkaz:
https://doaj.org/article/1ca77da391a84ad584cedd1fe6e59b48
Autor:
Kazi Rahman, Charles A Coomer, Saliha Majdoul, Selena Y Ding, Sergi Padilla-Parra, Alex A Compton
Publikováno v:
eLife, Vol 9 (2020)
The interferon-inducible transmembrane (IFITM) proteins belong to the Dispanin/CD225 family and inhibit diverse virus infections. IFITM3 reduces membrane fusion between cells and virions through a poorly characterized mechanism. Mutation of proline-r
Externí odkaz:
https://doaj.org/article/6d61b165ea014362a89fec8e64dae635
Autor:
Charles A Coomer, Irene Carlon-Andres, Maro Iliopoulou, Michael L Dustin, Ewoud B Compeer, Alex A Compton, Sergi Padilla-Parra
Publikováno v:
PLoS Pathogens, Vol 16, Iss 2, p e1008359 (2020)
There has been resurgence in determining the role of host metabolism in viral infection yet deciphering how the metabolic state of single cells affects viral entry and fusion remains unknown. Here, we have developed a novel assay multiplexing genetic
Externí odkaz:
https://doaj.org/article/c53ad4eca67b4c4a96160bb8ee44fc94
Autor:
Yadvinder S. Ahi, Diborah Yimer, Guoli Shi, Saliha Majdoul, Kazi Rahman, Alan Rein, Alex A. Compton
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
ABSTRACT Interferon-induced transmembrane (IFITM) proteins are encoded by many vertebrate species and exhibit antiviral activities against a wide range of viruses. IFITM3, when present in virus-producing cells, reduces the fusion potential of HIV-1 v
Externí odkaz:
https://doaj.org/article/6c0f7bd7082f450ba1ac4916471050db
Publikováno v:
Retrovirology, Vol 14, Iss 1, Pp 1-11 (2017)
Abstract The first responders of human antiviral immunity are components of the intrinsic immune response that reside within each and every one of our cells. This cell-autonomous arsenal consists of nucleic acid sensors and antiviral effectors strate
Externí odkaz:
https://doaj.org/article/53ce77bb20b345e1b0d3c495a494ba4f
SummaryOmicron emerged following COVID-19 vaccination campaigns, displaced previous SARS-CoV-2 variants of concern worldwide, and gave rise to lineages that continue to spread. Here, we show that Omicron exhibits increased infectivity in primary adul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::012356d5a72b0e0f169472e04d78950d
https://doi.org/10.1101/2023.05.06.539698
https://doi.org/10.1101/2023.05.06.539698
Autor:
Alex A Compton, Olivier Schwartz
Publikováno v:
PLoS Pathogens, Vol 13, Iss 2, p e1006099 (2017)
Externí odkaz:
https://doaj.org/article/6769dcf4d548411c897a359e1b0f0424