Zobrazeno 1 - 10
of 191
pro vyhledávání: '"Alex, von Kriegsheim"'
Autor:
Agata N. Makar, Alina Boraman, Peter Mosen, Joanne E. Simpson, Jair Marques, Tim Michelberger, Stuart Aitken, Ann P. Wheeler, Dominic Winter, Alex von Kriegsheim, Noor Gammoh
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Autophagy is a finely orchestrated process required for the lysosomal degradation of cytosolic components. The final degradation step is essential for clearing autophagic cargo and recycling macromolecules. Using a CRISPR/Cas9-based screen,
Externí odkaz:
https://doaj.org/article/6883251db50c4cf790616ebe8bd9529f
Autor:
Giovana Carrasco, Ifigeneia Stavrou, Mairi Treanor-Taylor, Henry Beetham, Martin Lee, Roza Masalmeh, Artur Carreras-Soldevila, David Hardman, Miguel O. Bernabeu, Alex von Kriegsheim, Gareth J. Inman, Adam Byron, Valerie G. Brunton
Publikováno v:
Oncogenesis, Vol 13, Iss 1, Pp 1-12 (2024)
Abstract Kindler syndrome (KS) is a rare genodermatosis resulting from loss-of-function mutations in FERMT1, the gene that encodes Kindlin-1. KS patients have a high propensity to develop aggressive and metastatic cutaneous squamous cell carcinoma (c
Externí odkaz:
https://doaj.org/article/8cc9d5b92cf442b7a04bdf1f0c5b321a
Autor:
Yuting Lu, Jana Travnickova, Mihaly Badonyi, Florian Rambow, Andrea Coates, Zaid Khan, Jair Marques, Laura C. Murphy, Pablo Garcia-Martinez, Richard Marais, Pakavarin Louphrasitthiphol, Alex H.Y. Chan, Christopher J. Schofield, Alex von Kriegsheim, Joseph A. Marsh, Valeria Pavet, Owen J. Sansom, Robert S. Illingworth, E. Elizabeth Patton
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114927- (2024)
Externí odkaz:
https://doaj.org/article/a0bd1226210f449ba3106f231ea41cf1
Autor:
Roly Megaw, Abigail Moye, Zhixian Zhang, Fay Newton, Fraser McPhie, Laura C. Murphy, Lisa McKie, Feng He, Melissa K. Jungnickel, Alex von Kriegsheim, Peter A. Tennant, Chloe Brotherton, Christine Gurniak, Alecia K. Gross, Laura M. Machesky, Theodore G. Wensel, Pleasantine Mill
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract As signalling organelles, cilia regulate their G protein-coupled receptor content by ectocytosis, a process requiring localised actin dynamics to alter membrane shape. Photoreceptor outer segments comprise an expanse of folded membranes (dis
Externí odkaz:
https://doaj.org/article/162f25833a9b438992ccafbff79b3556
Autor:
Eléa Gutierrez, Sharon Mitchell, Catherine Hambly, Kerry L. Sayle, Alex von Kriegsheim, John R. Speakman, Kate Britton
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110059- (2024)
Summary: This study characterized the effect of calorie restriction (CR) on elemental content and stable isotope ratio measurements of bone “collagen” and hair keratin. Adult mice on graded CR (10–40%; 84 days) showed decreased hair δ15N, δ13
Externí odkaz:
https://doaj.org/article/58c5bb42eee047ea92dee82d576f0c89
Autor:
Milad Ghomlaghi, Mandy Theocharous, Nhan Hoang, Sung-Young Shin, Alex von Kriegsheim, Eric O’ Neill, Tao Zhang, Lan K. Nguyen
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109031- (2024)
Summary: The transcriptional co-activator YAP forms complexes with distinct transcription factors, controlling cell fate decisions, such as proliferation and apoptosis. However, the mechanisms underlying its context-dependent function are poorly defi
Externí odkaz:
https://doaj.org/article/ac43d1e023b14adeb764bd7c42e1ff0f
Autor:
Frederic Li Mow Chee, Bruno Beernaert, Billie G. C. Griffith, Alexander E. P. Loftus, Yatendra Kumar, Jimi C. Wills, Martin Lee, Jessica Valli, Ann P. Wheeler, J. Douglas Armstrong, Maddy Parsons, Irene M. Leigh, Charlotte M. Proby, Alex von Kriegsheim, Wendy A. Bickmore, Margaret C. Frame, Adam Byron
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Cells transmit mechanical force to the nucleus via the cytoskeleton. Here, the authors reveal a role for the actin regulator Mena in force transmission at the nuclear envelope, where it regulates nuclear architecture, chromatin organization and gene
Externí odkaz:
https://doaj.org/article/c362f4cc95db4024a0d3eb4b310fffac
Autor:
Marco Sciacovelli, Aurelien Dugourd, Lorea Valcarcel Jimenez, Ming Yang, Efterpi Nikitopoulou, Ana S. H. Costa, Laura Tronci, Veronica Caraffini, Paulo Rodrigues, Christina Schmidt, Dylan Gerard Ryan, Timothy Young, Vincent R. Zecchini, Sabrina H. Rossi, Charlie Massie, Caroline Lohoff, Maria Masid, Vassily Hatzimanikatis, Christoph Kuppe, Alex Von Kriegsheim, Rafael Kramann, Vincent Gnanapragasam, Anne Y. Warren, Grant D. Stewart, Ayelet Erez, Sakari Vanharanta, Julio Saez-Rodriguez, Christian Frezza
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Primary and metastatic tumours have different metabolic phenotypes due to changes in nutrient availability. Here the authors perform multi-omic analyses of primary and metastatic renal cancer cells grown in a physiological medium and show that the re
Externí odkaz:
https://doaj.org/article/5e44e98a96b7403ead5d644996d99bb6
Autor:
Helen F. Titmarsh, Alex von Kriegsheim, Jimi C. Wills, Richard A. O’Connor, Kevin Dhaliwal, Margaret C. Frame, Samuel B. Pattle, David A. Dorward, Adam Byron, Ahsan R. Akram
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionThe composition and remodelling of the extracellular matrix (ECM) are important factors in the development and progression of cancers, and the ECM is implicated in promoting tumour growth and restricting anti-tumour therapies through mult
Externí odkaz:
https://doaj.org/article/7b547f7e40124ff7826557da8efed3d7
Autor:
Joy Edwards-Hicks, Huizhong Su, Maurizio Mangolini, Kubra K. Yoneten, Jimi Wills, Giovanny Rodriguez-Blanco, Christine Young, Kevin Cho, Heather Barker, Morwenna Muir, Ania Naila Guerrieri, Xue-Feng Li, Rachel White, Piotr Manasterski, Elena Mandrou, Karen Wills, Jingyu Chen, Emily Abraham, Kianoosh Sateri, Bin-Zhi Qian, Peter Bankhead, Mark Arends, Noor Gammoh, Alex von Kriegsheim, Gary J. Patti, Andrew H. Sims, Juan Carlos Acosta, Valerie Brunton, Kamil R. Kranc, Maria Christophorou, Erika L. Pearce, Ingo Ringshausen, Andrew J. Finch
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
MYC activation can sensitise cells to apoptosis upon glutamine withdrawal. Here the authors show that MYC activation enhances global transcription and translation that creates a metabolic demand, while glutamine limitation causes a metabolic demand a
Externí odkaz:
https://doaj.org/article/f58e694b2f6c429fb6bed6c1ae69a6f7