Výsledky vyhledávání - "Alex, Virasami"

Akademický článek

Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition

Autor: Branca I. Pereira, Oliver P. Devine, Milica Vukmanovic-Stejic, Emma S. Chambers, Priya Subramanian, Neil Patel, Alex Virasami, Neil J. Sebire, Veronica Kinsler, Alexis Valdovinos, Claude Jourdan LeSaux, João F. Passos, Antony Antoniou, Malcom H. A. Rustin, Judith Campisi, Arne N. Akbar

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

Senescent cells increase with ageing and may cause inflammatory conditions, but how this accumulation is mediated is still unclear. Here the authors show that senescent cells express HLA-E to suppress NKG2A-mediated natural killer and CD8 T cell acti

Externí odkaz: https://doaj.org/article/a849def66981451db25ae5092d6b7804

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Akademický článek

Multi-stage bioengineering of a layered oesophagus with in vitro expanded muscle and epithelial adult progenitors

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)

Combining decellularised scaffolds with patient-derived cells holds promise for bioengineering of functional tissues. Here the authors develop a two-stage approach to engineer an oesophageal graft that retains the structural organisation of native oe

Externí odkaz: https://doaj.org/article/04035db7e1a6472b9d4fc0a2bd25b51a

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Akademický článek

Argininosuccinic aciduria fosters neuronal nitrosative stress reversed by Asl gene transfer

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

Patients with mutations in the ASL gene present with argininosuccinic aciduria characterised by hyperammonaemia and cognitive impairment. Here, the authors show that cerebral disease involves neuronal nitrosative/oxidative stress that is not induced

Externí odkaz: https://doaj.org/article/bccd48b998f7466b8b4e37f6409acdb2

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Akademický článek

Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma

Autor: Jose Mario Gonzalez-Meljem, Scott Haston, Gabriela Carreno, John R. Apps, Sara Pozzi, Christina Stache, Grace Kaushal, Alex Virasami, Leonidas Panousopoulos, Seyedeh Neda Mousavy-Gharavy, Ana Guerrero, Mamunur Rashid, Nital Jani, Colin R. Goding, Thomas S. Jacques, David J. Adams, Jesus Gil, Cynthia L. Andoniadou, Juan Pedro Martinez-Barbera

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)

Senescent cells can promote tumour progression through the activation of a senescenceassociated secretory phenotype (SASP). Here, the authors show that SASP activation is associated with non-cell autonomous cell transformation and tumour initiation i

Externí odkaz: https://doaj.org/article/a0474958863a4634a3e1c6faf8951dc5

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Akademický článek

Learning from cases: Analysis of two cases of craniopharyngioma from the 19th to the 21st centuries. [version 1; peer review: 2 approved]

Autor: John R. Apps, J. Ciaran Hutchinson, Susan Shelmerdine, Alex Virasami, Eduard Winter, Thomas S. Jacques, Juan-Pedro Martinez-Barbera, Owen Arthurs, Thomas Czech

Publikováno v: F1000Research, Vol 8 (2019)

This manuscript describes the study of two cases of craniopharyngioma, which have been examined repeatedly over three separate centuries. This includes analysis by Josef Engel in 1839, who sought to uncover the physiological role of the pituitary gla

Externí odkaz: https://doaj.org/article/e1f70f2e62ee42b18c173a2382433568

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Supplementary Table S1 from Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes

Autor: Chris Jones, David T.W. Jones, Thomas S. Jacques, David W. Ellison, Sergey Popov, David Capper, Maria Vinci, Andrea Carai, Angela Mastronuzzi, Suzanne J. Baker, Felix Sahm, Stefan M. Pfister, Christof M. Kramm, Andreas von Deimling, Lynley V. Marshall, Fernando Carceller, Darren R. Hargrave, Kristian Aquilina, Matthias A. Karajannis, David S. Ziegler, Mark J. Cowley, Maria Tsoli, Stephen P. Lowis, Timothy E.G. Hassall, Andrew S. Moore, Simon Bailey, Francesca Diomedi-Camassei, Giovanna Stefania Colafati, Evelina Miele, Clare Mitchell, Tabitha Bloom, Olaf Witt, Marc Zuckermann, Dominik Sturm, Barbara C. Worst, Lotte Hiddingh, Andrey Korshunov, Pablo Hernáiz Driever, Felipe Andreiuolo, Torsten Pietsch, Simone Hettmer, Kornelius Kerl, Winand N.M. Dinjens, Martin Ebinger, Martin U. Schuhmann, Jens Schittenhelm, Michael Karremann, Michael Capra, Jane B. Cryan, Michael Farrell, Petter Brandal, Thale Kristin Olsen, David A. Solomon, Monika Ashok Davare, Lissa Baird, Matthew D. Wood, Barbara Faganel Kotnik, Mara Popović, Shani Caspi, Ho-Keung Ng, Roger Packer, Irene Slavc, Christine Haberler, Matthias Preusser, Tobey J. Macdonald, Paula Z. Proszek, Debbie Hughes, Marc K. Rosenblum, Stephen W. Gilheeney, Ira J. Dunkel, Martin Sill, Simon P. Robinson, Jessica K.R. Boult, Rachael Natrajan, Claire Cairns, Bassel Zebian, Christopher Chandler, Safa Al-Sarraj, Lawrence J. Doey, Andrew J. Martin, Leslie Bridges, Matija Snuderl, David E. Kram, Uwe Kordes, Ulrich Schüller, Jeffrey Knipstein, Stephen Crosier, Mellissa Maybury, Catherine Rowe, Kathreena M. Kurian, Michael Hubank, Ji Wen, Wilda Orisme, James D. Dalton, Kelly Haupfear, Mark Kristiansen, Jane Chalker, Aimee Avery, Amy R. Fairchild, Alex Virasami, Louise Howell, Anna Burford, Valeria Molinari, Diana M. Carvalho, Sara Temelso, Elisa Izquierdo, Iris Stoler, Tejus A. Bale, Scott Newman, Ruth G. Tatevossian, Jessica C. Pickles, Britta Ismer, Alan Mackay, Matthew Clarke

Supplementary Table S1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04d97c92485c6eb10e27f5e8a1018f6
https://doi.org/10.1158/2159-8290.22535600

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Supplementary Data from Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes

Supplementary Figures and Legends

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c65c2845bc3337ffe6dc1ec69cb64973
https://doi.org/10.1158/2159-8290.22535603

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Data from Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes

Infant high-grade gliomas appear clinically distinct from their counterparts in older children, indicating that histopathologic grading may not accurately reflect the biology of these tumors. We have collected 241 cases under 4 years of age, and carr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c88928a63f70570ceb077ac4ab638a2
https://doi.org/10.1158/2159-8290.c.6547883.v1

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