Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Alex, Tonks"'
Autor:
Ana Catarina Menezes, Christabel Dixon, Anna Scholz, Rachael Nicholson, Adam Leckenby, Aleksandra Azevedo, Sarah Baker, Amanda F. Gilkes, Sara Davies, Richard L. Darley, Alex Tonks
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract RUNX proteins belong to a family of transcription factors essential for cellular proliferation, differentiation, and apoptosis with emerging data implicating RUNX3 in haematopoiesis and haematological malignancies. Here we show that RUNX3 pl
Externí odkaz:
https://doaj.org/article/708bfa0ef22d450dae8c94c032ab776a
CD200 ectodomain shedding into the tumor microenvironment leads to NK cell dysfunction and apoptosis
Autor:
Huw J. Morgan, Elise Rees, Simone Lanfredini, Kate A. Powell, Jasmine Gore, Alex Gibbs, Charlotte Lovatt, Gemma E. Davies, Carlotta Olivero, Boris Y. Shorning, Giusy Tornillo, Alex Tonks, Richard Darley, Eddie C.Y. Wang, Girish K. Patel
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 21 (2022)
The basis of immune evasion, a hallmark of cancer, can differ even when cancers arise from one cell type such as in the human skin keratinocyte carcinomas: basal and squamous cell carcinoma. Here we showed that the basal cell carcinoma tumor–initia
Externí odkaz:
https://doaj.org/article/ea703a273eba40cda8c0b9d20462893e
Autor:
Rachael Nicholson, Ana Catarina Menezes, Aleksandra Azevedo, Adam Leckenby, Sara Davies, Claire Seedhouse, Amanda Gilkes, Steve Knapper, Alex Tonks, Richard L. Darley
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The protein kinase C (PKC) family of serine/threonine kinases are pleiotropic signaling regulators and are implicated in hematopoietic signaling and development. Only one isoform however, PKCϵ, has oncogenic properties in solid cancers where it is a
Externí odkaz:
https://doaj.org/article/e85da284ca174933b6750e1a2cafebd7
Autor:
Megan Wagstaff, Olga Tsaponina, Gilian Caalim, Hayley Greenfield, Leanne Milton-Harris, Erika J. Mancini, Allison Blair, Kate J. Heesom, Alex Tonks, Richard L. Darley, Stefan G. Roberts, Rhys G. Morgan
Publikováno v:
Haematologica, Vol 108, Iss 1 (2022)
Externí odkaz:
https://doaj.org/article/a6ff5983437d400480a77a8722f391de
Autor:
Juan Bautista Menendez-Gonzalez, Milica Vukovic, Ali Abdelfattah, Lubaid Saleh, Alhomidi Almotiri, Leigh-anne Thomas, Aloña Agirre-Lizaso, Aleksandra Azevedo, Ana Catarina Menezes, Giusy Tornillo, Sarah Edkins, Kay Kong, Peter Giles, Fernando Anjos-Afonso, Alex Tonks, Ashleigh S. Boyd, Kamil R. Kranc, Neil P. Rodrigues
Publikováno v:
Stem Cell Reports, Vol 13, Iss 2, Pp 291-306 (2019)
Summary: Subversion of transcription factor (TF) activity in hematopoietic stem/progenitor cells (HSPCs) leads to the development of therapy-resistant leukemic stem cells (LSCs) that drive fulminant acute myeloid leukemia (AML). Using a conditional m
Externí odkaz:
https://doaj.org/article/8fa51b867c2d478fb185ad8f114dbac4
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Acute myeloid leukemia (AML) is a heterogeneous disease with poor clinical outcomes. We have previously shown that constitutive activation of NADPH oxidase 2 (NOX2), resulting in over-production of reactive oxygen species (ROS), occurs in over 60% of
Externí odkaz:
https://doaj.org/article/3e2928d9903a4f1e987f6c57413f637d
Autor:
James Hillier, Gemma J. Allcott, Laura A. Guest, Wayne Heaselgrave, Alex Tonks, Myra E. Conway, Amy L. Cherry, Steven J. Coles
Publikováno v:
Antioxidants, Vol 11, Iss 4, p 683 (2022)
The cytosolic branched-chain aminotransferase (BCAT1) has received attention for its role in myeloid leukaemia development, where studies indicate metabolic adaptations due to BCAT1 up-regulation. BCAT1, like the mitochondria isoform (BCAT2), shares
Externí odkaz:
https://doaj.org/article/352984e1debc41599335d19c183f4b01
Autor:
Namrata Rastogi, Juan Bautista Menendez Gonzalez, Vikas Kumar Srivastava, Bader Alanazi, Rehab N. Alanazi, Owen M. Hughes, Niamh S. O’Neill, Amanda F. Gilkes, Neil Ashley, Sumukh Deshpande, Robert Andrews, Adam Mead, Neil P. Rodrigues, Steve Knapper, Richard L. Darley, Alex Tonks
Publikováno v:
Leukemia. 37:276-287
Nuclear factor I-C (NFIC) belongs to a family of NFI transcription factors that binds to DNA through CAATT-boxes and are involved in cellular differentiation and stem cell maintenance. Here we show NFIC protein is significantly overexpressed in 69% o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ba95674c3b49828743805bd6eb22c08
https://doi.org/10.1038/s41375-022-01801-z
https://doi.org/10.1038/s41375-022-01801-z
Autor:
Rhys G. Morgan, Jenna Ridsdale, Megan Payne, Kate J. Heesom, Marieangela C. Wilson, Andrew Davidson, Alexander Greenhough, Sara Davies, Ann C. Williams, Allison Blair, Marian L. Waterman, Alex Tonks, Richard L. Darley
Publikováno v:
Haematologica, Vol 104, Iss 7 (2019)
Canonical Wnt/β-catenin signaling is frequently dysregulated in myeloid leukemias and is implicated in leukemogenesis. Nuclear-localized β-catenin is indicative of active Wnt signaling and is frequently observed in acute myeloid leukemia (AML) pati
Externí odkaz:
https://doaj.org/article/67f282a8773c4e4da92b6fe97861268a
Autor:
Alex Tonks, Richard L. Darley, Nader Omidvar, Paul S. Hole, Sara Davies, Michelle Doyle, Marie Hodges, Namrata Rastogi, Goitseone L. Hopkins, Andrew J. Robinson
Acute myeloid leukemia (AML) is a heterogeneous clonal disorder with a poor clinical outcome. Previously, we showed that overproduction of reactive oxygen species (ROS), arising from constitutive activation of NOX2 oxidase, occurs in >60% of patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a92f27d68149ad8b079b0b7d7f73f2
https://doi.org/10.1158/0008-5472.c.6512380.v1
https://doi.org/10.1158/0008-5472.c.6512380.v1
