Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Alex, Menys"'
Autor:
Christabella Ng, Helen Barr, Caroline Hoad, Neele S Dellschaft, Robin Spiller, Luca Marciani, Alan R Smyth, Trevor Hill, Colin Crooks, Jochen G Mainz, Alex Menys, Giles Major, Penny A. Gowland
Publikováno v:
NIHR Open Research, Vol 3 (2024)
Background People with cystic fibrosis (CF) can experience recurrent chest infections, pancreatic exocrine insufficiency and gastrointestinal symptoms. New cystic fibrosis transmembrane conductance regulator (CFTR) modulator drugs improve lung functi
Externí odkaz:
https://doaj.org/article/5c1c3656d9e84dffb5b38374c1d6241e
Autor:
Khaled Heissam, Nichola Abrehart, Caroline L Hoad, Jeff Wright, Alex Menys, Kathryn Murray, Paul M Glover, Geoffrey Hebbard, Penny A Gowland, Jason Baker, William L Hasler, Robin C Spiller, Maura Corsetti, James G Brasseur, Bart Hens, Kerby Shedden, Joseph Dickens, Deanna M Mudie, Greg E Amidon, Gordon L Amidon, Luca Marciani
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0241441 (2020)
ObjectiveThe gastrointestinal environment in which drug products need to disintegrate before the drug can dissolve and be absorbed has not been studied in detail due to limitations, especially invasiveness of existing techniques. Minimal in vivo data
Externí odkaz:
https://doaj.org/article/8b870100c3494f05b33becca50d1d77a
Autor:
Konstantinos C. Fragkos, María Claudia Picasso Bouroncle, Shankar Kumar, Lucy Caselton, Alex Menys, Alan Bainbridge, Stuart A. Taylor, Francisco Torrealdea, Tomoko Kumagai, Simona Di Caro, Farooq Rahman, Jane Macnaughtan, Manil D. Chouhan, Shameer Mehta
Publikováno v:
Nutrients, Vol 12, Iss 7, p 2151 (2020)
(1) Background: Intestinal failure-associated liver disease (IFALD) in adults is characterized by steatosis with variable progression to fibrosis/cirrhosis. Reference standard liver biopsy is not feasible for all patients, but non-invasive serologica
Externí odkaz:
https://doaj.org/article/168ee398bfe349ec8243d429164a3167
Autor:
H Fitzke, Manil D Chouhan, Stuart A. Taylor, Rajeshwar P. Mookerjee, David Atkinson, Nathan Davies, Mark F. Lythgoe, Steve Halligan, Alan Bainbridge, Alex Menys
Publikováno v:
Abdominal Radiology. 46:4660-4670
MR elastography and magnetization-tagging use liver stiffness (LS) measurements to diagnose fibrosis but require physical drivers, specialist sequences and post-processing. Here we evaluate non-rigid registration of dynamic two-dimensional cine MRI i
Autor:
Thomas Hampshire, Alex Menys, Asif Jaffer, Gauraang Bhatnagar, Shonit Punwani, David Atkinson, Steve Halligan, David J Hawkes, Stuart A Taylor
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0168317 (2017)
MRI has recently been applied as a tool to quantitatively evaluate the response to therapy in patients with Crohn's disease, and is the preferred choice for repeated imaging. Bowel wall thickness on MRI is an important biomarker of underlying inflamm
Externí odkaz:
https://doaj.org/article/31a6e23bc91744669a64a2921b909e62
Publikováno v:
Topics in Magnetic Resonance Imaging. 30:31-41
In this review article, we present the latest developments in quantitative imaging biomarkers based on magnetic resonance imaging (MRI), applied to the diagnosis, assessment of response to therapy, and assessment of prognosis of Crohn disease. We als
Autor:
Ruaridh M. Gollifer, Stuart A. Taylor, Alex Menys, Natalia Zarate‐Lopez, Dave Chatoor, Anton Emmanuel, David Atkinson
Publikováno v:
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 34(10)
Gastrointestinal symptoms in functional gut disorders occur without any discernible structural gut abnormality. Preliminary observations on enteric MRI suggest possible abnormal content and motility of the terminal ileum (TI) in constipation-predomin
Publikováno v:
BJR open, 4(1)
Objectives: To evaluate the effect of bowel dilation on cine-MRI small bowel motility measurements, by comparing a conventional motility score (including bowel wall and lumen) with a bowel wall-specific motility score in healthy and diseased populati
Autor:
Shankar Kumar, Liina Palm, Trevor Gaunt, H Fitzke, Dyanne Rampling, Stuart A. Taylor, Lucia Cococcioni, Alex Menys, Fevronia Kiparissi, Tom A. Watson
Publikováno v:
European Radiology. 31:775-784
Investigate the relationship between quantified terminal ileal (TI) motility and histopathological activity grading, Crohn Disease MRI Index (CDMI) and faecal calprotectin. Retrospective review of children with Crohn disease or unclassified inflammat
Autor:
Khalid Latief, Stuart A. Taylor, Shellie Jean Radford, Asseel Khalaf, Luca Marciani, Gulzar Singh, Yirga Falcone, Alex Menys, Adam Nowak, Robin C. Spiller, Caroline L. Hoad, Melanie Lingaya, Gordon W. Moran, Penny A. Gowland
Publikováno v:
The American Journal of Clinical Nutrition. 111:131-140
BACKGROUND Crohn's disease (CD) patients suffer postprandial aversive symptoms, which can lead to anorexia and malnutrition. Changes in the regulation of gut hormones and gut dysmotility are believed to play a role. OBJECTIVES This study aimed to inv