Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Alex, Macharia"'
Autor:
Albert Koulman, Kelsey Jones, James Berkley, Judd Walson, Eric Houpt, David S. Wishart, Christina L. Lancioni, Moses Ngari, Lei Xia, James M. Njunge, Abdoulaye Hama Diallo, Kirkby Tickell, Md. Amran Gazi, Abu Sadat Mohammad Sayeem Bin Shahid, Zaubina Kazi, Ali Saleem, Caroline Tigoi, Syed Ali, Emily Yoshioka, Ezekiel Mupere, Moses Mburu, Mohammod Jobayer Chisti, Bonface Gichuki, Narshion Ngao, Wilson Gumbi, Elisha Omer, Robert Bandsma, Benson Singa, Wieger Voskuijl, Tahmeed Ahmed, Alex Macharia, Thomas N. Williams, Anna Mitchel, Johnstone Makale, Joe Gogain, Jessica Williams, Rupasri Mandal, Nebojsa Janjic, Michael Routledge, Hang Wu, Camilo Espinosa, Yun Yun Gong, Jie Liu, Nima Aghaeepour, Hilary Browne, Trevor D. Lawley, Doreen Rwigi, Yan Shao, Timothy Kaburu, Kevin Kariuki, Lisa Gartner, Holm H. Uhlig
Publikováno v:
Gates Open Research, Vol 6 (2022)
Introduction: Many acutely ill children in low- and middle-income settings have a high risk of mortality both during and after hospitalisation despite guideline-based care. Understanding the biological mechanisms underpinning mortality may suggest op
Externí odkaz:
https://doaj.org/article/4f784e51afb14738813820fdbf1f5a7d
Autor:
Michelle K. Muthui, Polycarp Mogeni, Kennedy Mwai, Christopher Nyundo, Alex Macharia, Thomas N. Williams, George Nyangweso, Juliana Wambua, Daniel Mwanga, Kevin Marsh, Philip Bejon, Melissa C. Kapulu
Publikováno v:
Wellcome Open Research, Vol 4 (2019)
Background: Interventions to block malaria transmission from humans to mosquitoes are currently in development. To be successfully implemented, key populations need to be identified where the use of these transmission-blocking and/or reducing strateg
Externí odkaz:
https://doaj.org/article/c4f75ddd48b44efc98dad25319280644
Autor:
Anthony O. Etyang, Sailoki Kapesa, Emily Odipo, Evasius Bauni, Catherine Kyobutungi, Marwah Abdalla, Paul Muntner, Solomon K. Musani, Alex Macharia, Thomas N. Williams, J. Kennedy Cruickshank, Liam Smeeth, J. Anthony G. Scott
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 6 (2019)
Background Malaria exposure in childhood may contribute to high blood pressure (BP) in adults. We used sickle cell trait (SCT) and α+thalassemia, genetic variants conferring partial protection against malaria, as tools to test this hypothesis. Metho
Externí odkaz:
https://doaj.org/article/cd91cfa41a114de1a96e6b355528c996
Autor:
Shebe Mohammed, Kennedy Mwai, Johnstone Makale, Neema Mturi, Thomas N. Williams, Alex Macharia, Sarah H. Atkinson, Esther Muthumbi, Salim Mwarumba, John Muthii Muriuki, Reagan M. Mogire, Philip Bejon, Manfred Nairz, J. Anthony G. Scott, Kelvin M. Abuga, Sophie Uyoga
Publikováno v:
Haematologica. 107:1589-1598
Malaria and invasive non-typhoidal Salmonella (NTS) are life-threatening infections that often co-exist in African children. The iron-regulatory hormone hepcidin is highly upregulated during malaria and controls the availability of iron, a critical n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59ee1cbd8a9c48a4d3846c3877940e58
https://doi.org/10.3324/haematol.2021.279316
https://doi.org/10.3324/haematol.2021.279316
Autor:
Anthony O. Etyang, Christopher Khayeka‐Wandabwa, Sailoki Kapesa, Esther Muthumbi, Emily Odipo, Marylene Wamukoya, Nicholas Ngomi, Tilahun Haregu, Catherine Kyobutungi, Metrine Tendwa, Johnstone Makale, Alex Macharia, J. Kennedy Cruickshank, Liam Smeeth, J. Anthony G. Scott, Thomas N. Williams
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 4 (2017)
BackgroundRecent studies have discovered that α‐globin is expressed in blood vessel walls where it plays a role in regulating vascular tone. We tested the hypothesis that blood pressure (BP) might differ between normal individuals and those with
Externí odkaz:
https://doaj.org/article/d42d8beadc204f8f8ea9496cf8e4f754
Autor:
Johnstone Makale, Amidou Diarra, Crystal D Karakochuk, Ruth Mitchell, Robert W. Snow, Francis M. Ndungu, Laura M. Raffield, Kirk A. Rockett, Alexander J. Mentzer, Parminder S. Suchdev, John Muthii Muriuki, Rita Wegmüller, Catherine Kyobutungi, Sodiomon B. Sirima, Thomas N. Williams, Dominic P. Kwiatkowski, Moses Gwamaka, Clare L. Cutland, Seth Adu-Afarwuah, Adrian V. S. Hill, Alison M. Elliott, James P. Wirth, Wandia Kimita, Patrick E. Duffy, Caroline Ngetsa, Manjinder S. Sandhu, Andrew M. Prentice, Christine P. Stewart, Kendra A. Byrd, Michal Fried, Alireza Morovat, Emily L. Webb, Alex Macharia, Timothy J. Green, Alfred B. Tiono, Sarah H. Atkinson, Shabir A. Madhi, Reina Engle-Stone, Philip Bejon, George Davey Smith, Alex Ndjebayi, Solomon K. Musani, Swaib A. Lule, Anthony Etyang
Publikováno v:
Nature medicine
muriuki, J, Mentzer, A J, Mitchell, R E, Webb, E L, Etyang, A O, Kyobutungi, C, Morovat, A, Kimita, W, Ndungu, F M, Macharia, A W, Ngetsa, C, Makale, J, Lule, S A, Musani, S K, Raffield, L M, Cutland, C L, Sirima, S B, Diarra, A, Tiono, A B, Fried, M, Gwamaka, M, Adu-Afarwuah, S & Davey Smith, G 2021, ' Malaria is a cause of iron deficiency in African children ', Nature Medicine, vol. 27, no. 4, pp. 653-658 . https://doi.org/10.1038/s41591-021-01238-4
Nature medicine, vol 27, iss 4
muriuki, J, Mentzer, A J, Mitchell, R E, Webb, E L, Etyang, A O, Kyobutungi, C, Morovat, A, Kimita, W, Ndungu, F M, Macharia, A W, Ngetsa, C, Makale, J, Lule, S A, Musani, S K, Raffield, L M, Cutland, C L, Sirima, S B, Diarra, A, Tiono, A B, Fried, M, Gwamaka, M, Adu-Afarwuah, S & Davey Smith, G 2021, ' Malaria is a cause of iron deficiency in African children ', Nature Medicine, vol. 27, no. 4, pp. 653-658 . https://doi.org/10.1038/s41591-021-01238-4
Nature medicine, vol 27, iss 4
Malaria and iron deficiency (ID) are common and interrelated public health problems in African children. Observational data suggest that interrupting malaria transmission reduces the prevalence of ID1. To test the hypothesis that malaria might cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96de8a1482060483305a4bdc27e6a8a7
http://europepmc.org/articles/PMC7610676
http://europepmc.org/articles/PMC7610676
Autor:
J. Anthony G. Scott, Mohammed Shebe, Thomas N. Williams, Gideon Nyutu, Kennedy O. Awuondo, Sophie Uyoga, Norbert Peshu, Alex Macharia, Neema Mturi, Carolyne M. Ndila, Kathryn Maitland, Benjamin Tsofa
Publikováno v:
Blood Adv
Few previous studies have reported the effects of glucose-6-phosphate dehydrogenase (G6PD)–deficiency on child health in Africa. We conducted a case-control study in which cases (n = 6829) were children admitted, for any reason, to Kilifi County Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead90676076f786812f4b98b9b67f0d2
https://doi.org/10.1182/bloodadvances.2020003015
https://doi.org/10.1182/bloodadvances.2020003015
Autor:
James M. Njunge, Kirkby Tickell, Abdoulaye Hama Diallo, Abu Sadat Mohammad Sayeem Bin Shahid, Md. Amran Gazi, Ali Saleem, Zaubina Kazi, Syed Ali, Caroline Tigoi, Ezekiel Mupere, Christina L. Lancioni, Emily Yoshioka, Mohammod Jobayer Chisti, Moses Mburu, Moses Ngari, Narshion Ngao, Bonface Gichuki, Elisha Omer, Wilson Gumbi, Benson Singa, Robert Bandsma, Tahmeed Ahmed, Wieger Voskuijl, Thomas N. Williams, Alex Macharia, Johnstone Makale, Anna Mitchel, Jessica Williams, Joe Gogain, Nebojsa Janjic, Rupasri Mandal, David S. Wishart, Hang Wu, Lei Xia, Michael Routledge, Yun Yun Gong, Camilo Espinosa, Nima Aghaeepour, Jie Liu, Eric Houpt, Trevor D. Lawley, Hilary Browne, Yan Shao, Doreen Rwigi, Kevin Kariuki, Timothy Kaburu, Holm H. Uhlig, Lisa Gartner, Kelsey Jones, Albert Koulman, Judd Walson, James Berkley
Publikováno v:
Gates Open Research, 6:77
Gates Open Research, 6:77. F1000 Research Ltd.
Walson, J, Berkley, J, Njunge, J M, Tickell, K, Diallo, A H, Sayeem Bin Shahid, A S M, Gazi, M A, Saleem, A, Kazi, Z, Ali, S, Tigoi, C, Mupere, E, Lancioni, C L, Yoshioka, E, Chisti, M J, Mburu, M, Ngari, M, Ngao, N, Gichuki, B, Omer, E, Gumbi, W, Singa, B, Bandsma, R, Ahmed, T, Voskuijl, W, Williams, T N, Macharia, A, Makale, J, Mitchel, A, Williams, J, Gogain, J, Janjic, N, Mandal, R, Wishart, D S, Wu, H, Xia, L, Routledge, M, Gong, Y Y, Espinosa, C, Aghaeepour, N, Liu, J, Houpt, E, Lawley, T D, Browne, H, Shao, Y, Rwigi, D, Kariuki, K, Kaburu, T, Uhlig, H H, Gartner, L, Jones, K & Koulman, A 2022, ' The Childhood Acute Illness and Nutrition (CHAIN) network nested case-cohort study protocol : A multi-omics approach to understanding mortality among children in sub-Saharan Africa and South Asia ', Gates Open Research, vol. 6, 77 . https://doi.org/10.12688/gatesopenres.13635.2
Gates Open Research, 6:77. F1000 Research Ltd.
Walson, J, Berkley, J, Njunge, J M, Tickell, K, Diallo, A H, Sayeem Bin Shahid, A S M, Gazi, M A, Saleem, A, Kazi, Z, Ali, S, Tigoi, C, Mupere, E, Lancioni, C L, Yoshioka, E, Chisti, M J, Mburu, M, Ngari, M, Ngao, N, Gichuki, B, Omer, E, Gumbi, W, Singa, B, Bandsma, R, Ahmed, T, Voskuijl, W, Williams, T N, Macharia, A, Makale, J, Mitchel, A, Williams, J, Gogain, J, Janjic, N, Mandal, R, Wishart, D S, Wu, H, Xia, L, Routledge, M, Gong, Y Y, Espinosa, C, Aghaeepour, N, Liu, J, Houpt, E, Lawley, T D, Browne, H, Shao, Y, Rwigi, D, Kariuki, K, Kaburu, T, Uhlig, H H, Gartner, L, Jones, K & Koulman, A 2022, ' The Childhood Acute Illness and Nutrition (CHAIN) network nested case-cohort study protocol : A multi-omics approach to understanding mortality among children in sub-Saharan Africa and South Asia ', Gates Open Research, vol. 6, 77 . https://doi.org/10.12688/gatesopenres.13635.2
Introduction: Many acutely ill children in low- and middle-income settings have a high risk of mortality both during and after hospitalisation despite guideline-based care. Understanding the biological mechanisms underpinning mortality may suggest op
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca2507dc93316c0c7dd8531742d7cbd
http://www.scopus.com/inward/record.url?scp=85141985804&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85141985804&partnerID=8YFLogxK
Autor:
Emily L. Webb, Alex Macharia, Shabir A. Madhi, Wandia Kimita, Clare L. Cutland, Thomas N. Williams, Amidou Diarra, Sarah H. Atkinson, Alfred B. Tiono, John M. Pettifor, John Muthii Muriuki, Reagan M. Mogire, Alireza Morovat, Manjinder S. Sandhu, Andrew M. Prentice, Adebowale Adeyemo, Swaib A. Lule, Philip Bejon, Alison M. Elliott, Sodiomon B. Sirima, Francis M. Ndungu, Alexander J. Mentzer
Publikováno v:
BMC Medicine
BMC Medicine, Vol 19, Iss 1, Pp 1-14 (2021)
BMC Medicine, Vol 19, Iss 1, Pp 1-14 (2021)
Background Children living in sub-Saharan Africa have a high burden of rickets and infectious diseases, conditions that are linked to vitamin D deficiency. However, data on the vitamin D status of young African children and its environmental and gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::280afed75ab5c658cf54230d514ae56c
https://doi.org/10.1186/s12916-021-01985-8
https://doi.org/10.1186/s12916-021-01985-8
Autor:
John Muthii Muriuki, Alex Macharia, Sarah H. Atkinson, J. Anthony G. Scott, Thomas N. Williams, Sophie Uyoga, Kelvin M. Abuga, Philip Bejon, Salim Mwarumba, Reagan M. Mogire, Johnstone Makale, Neema Mturi, Kennedy Mwai, Shebe Mohammed, Manfred Nairz
BackgroundSevere malaria and invasive non-typhoidal Salmonella (NTS) are life-threatening infections that often co-exist in African children. The iron-regulatory hormone hepcidin is highly upregulated during malaria and controls the availability of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db54a194231ee25dba24f3a3fea3ff22
https://doi.org/10.1101/2021.04.08.21255042
https://doi.org/10.1101/2021.04.08.21255042