Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Alex, Groisman"'
Autor:
Elisabeth Ghabache, Yuansheng Cao, Yuchuan Miao, Alex Groisman, Peter N Devreotes, Wouter‐Jan Rappel
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 12, Pp 1-21 (2021)
Abstract Motile cells can use and switch between different modes of migration. Here, we use traction force microscopy and fluorescent labeling of actin and myosin to quantify and correlate traction force patterns and cytoskeletal distributions in Dic
Externí odkaz:
https://doaj.org/article/4e3e8f1a87ba4047a333ba182bf5d986
Autor:
Sangyoon J Han, Evgenia V Azarova, Austin J Whitewood, Alexia Bachir, Edgar Guttierrez, Alex Groisman, Alan R Horwitz, Benjamin T Goult, Kevin M Dean, Gaudenz Danuser
Publikováno v:
eLife, Vol 10 (2021)
Talin and vinculin are mechanosensitive proteins that are recruited early to integrin-based nascent adhesions (NAs). In two epithelial cell systems with well-delineated NA formation, we find these molecules concurrently recruited to the subclass of N
Externí odkaz:
https://doaj.org/article/6da67ed4c2294cc29a0a867acd5126d3
Autor:
Bart Weijts, Edgar Gutierrez, Semion K. Saikin, Ararat J. Ablooglu, David Traver, Alex Groisman, Eugene Tkachenko
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
The mechanisms of sensing of blood flow and responses to it in vascular remodelling are poorly understood. Here, the authors show that in zebrafish blood flow controls both the fate determination of individual blood vessels and the arterial versus ve
Externí odkaz:
https://doaj.org/article/b1794bd622bc45d3a2fefd0e655fefd7
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Bacterial biofilms are an increasingly important medical problem but the mechanisms by which they develop remain largely unknown. Here, using a high-throughput approach, the authors show that biofilm formation is linked to self-imposed mechanical str
Externí odkaz:
https://doaj.org/article/a275354c255049fcb1b857c5361648a5
Autor:
Michael Abadier, Akula Bala Pramod, Sara McArdle, Alex Marki, Zhichao Fan, Edgar Gutierrez, Alex Groisman, Klaus Ley
Publikováno v:
Cell Reports, Vol 21, Iss 13, Pp 3885-3899 (2017)
The adaptive immune response involves T cell differentiation and migration to sites of inflammation. T cell trafficking is initiated by rolling on inflamed endothelium. Tethers and slings, discovered in neutrophils, facilitate cell rolling at high sh
Externí odkaz:
https://doaj.org/article/2cf9a5879a9f4aa698706144be6e373f
Autor:
Richa Karmakar, Christoph Schich, Nadine Kamprad, Vanessa Scheller, Edgar Gutierrez, Alex Groisman, Wouter-Jan Rappel, Marco Tarantola
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0236171 (2020)
Cell-substrate adhesion of the social amoeba Dictyostelium discoideum, a model organism often used for the study of chemotaxis, is non-specific and does not involve focal adhesion complexes. Therefore, micropatterned substrates where adherent Dictyos
Externí odkaz:
https://doaj.org/article/94be9124a2824fbf96bac87b05326b4e
Autor:
Zhichao Fan, Sara McArdle, Alex Marki, Zbigniew Mikulski, Edgar Gutierrez, Britta Engelhardt, Urban Deutsch, Mark Ginsberg, Alex Groisman, Klaus Ley
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Integrin β2 attachment regulates inflammation via effects on neutrophil rolling and extravasation through sequential integrin extension then headpiece opening. Here the authors show an alternative open headpiece prior to extension stabilized in cisb
Externí odkaz:
https://doaj.org/article/bf21e777e3c842518d89e822f46d2e45
Autor:
Kian-Yong Lee, Rebecca A Green, Edgar Gutierrez, J Sebastian Gomez-Cavazos, Irina Kolotuev, Shaohe Wang, Arshad Desai, Alex Groisman, Karen Oegema
Publikováno v:
eLife, Vol 7 (2018)
Throughout metazoans, germ cells undergo incomplete cytokinesis to form syncytia connected by intercellular bridges. Gamete formation ultimately requires bridge closure, yet how bridges are reactivated to close is not known. The most conserved bridge
Externí odkaz:
https://doaj.org/article/8d54a258e8bc4974992ec3a275f36ca7
Autor:
My N. Tran, Edgar Gutierrez, Andrew R. Holder, Sameer B. Shah, Lawrence S.B. Goldstein, Angels Almenar-Queralt, Brian G. Bober, Rodrigo S. Chaves, Alex Groisman, Elizabeth A. Roberts, Brian P. Head, Alexandra M. Balcer, Andrea M. Dickey
Publikováno v:
J Neurosci
Traumatic brain injury (TBI) results in disrupted brain function following impact from an external force and is a risk factor for sporadic Alzheimer's disease (AD). Although neurologic symptoms triggered by mild traumatic brain injuries (mTBI), the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdb8ee8080a75953f3ee84ca2359a547
https://doi.org/10.1523/jneurosci.2553-20.2021
https://doi.org/10.1523/jneurosci.2553-20.2021
Autor:
Anja Paulick, Vladimir Jakovljevic, SiMing Zhang, Michael Erickstad, Alex Groisman, Yigal Meir, William S Ryu, Ned S Wingreen, Victor Sourjik
Publikováno v:
eLife, Vol 6 (2017)
In bacteria various tactic responses are mediated by the same cellular pathway, but sensing of physical stimuli remains poorly understood. Here, we combine an in-vivo analysis of the pathway activity with a microfluidic taxis assay and mathematical m
Externí odkaz:
https://doaj.org/article/213c77bd1cb84e339e362e11214654cc