Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Alex, Duval"'
Autor:
Vincent Jonchère, Hugo Montémont, Enora Le Scanf, Aurélie Siret, Quentin Letourneur, Emmanuel Tubacher, Christophe Battail, Assane Fall, Karim Labreche, Victor Renault, Toky Ratovomanana, Olivier Buhard, Ariane Jolly, Philippe Le Rouzic, Cody Feys, Emmanuelle Despras, Habib Zouali, Rémy Nicolle, Pascale Cervera, Magali Svrcek, Pierre Bourgoin, Hélène Blanché, Anne Boland, Jérémie Lefèvre, Yann Parc, Mehdi Touat, Franck Bielle, Danielle Arzur, Gwennina Cueff, Catherine Le Jossic-Corcos, Gaël Quéré, Gwendal Dujardin, Marc Blondel, Cédric Le Maréchal, Romain Cohen, Thierry André, Florence Coulet, Pierre de la Grange, Aurélien de Reyniès, Jean-François Fléjou, Florence Renaud, Agusti Alentorn, Laurent Corcos, Jean-François Deleuze, Ada Collura, Alex Duval
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-26 (2024)
Abstract Background Microsatellite instability (MSI) due to mismatch repair deficiency (dMMR) is common in colorectal cancer (CRC). These cancers are associated with somatic coding events, but the noncoding pathophysiological impact of this genomic i
Externí odkaz:
https://doaj.org/article/87efc7be65b6480c8bf4509103a6aab4
Autor:
Isaias Hernández-Verdin, Kadir C. Akdemir, Daniele Ramazzotti, Giulio Caravagna, Karim Labreche, Karima Mokhtari, Khê Hoang-Xuan, Matthieu Peyre, Franck Bielle, Mehdi Touat, Ahmed Idbaih, Alex Duval, Marc Sanson, Agustí Alentorn
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-14 (2022)
Abstract Activation-induced cytidine deaminase, AICDA or AID, is a driver of somatic hypermutation and class-switch recombination in immunoglobulins. In addition, this deaminase belonging to the APOBEC family may have off-target effects genome-wide,
Externí odkaz:
https://doaj.org/article/10e4ff93711e45efae0a1c2b4a7ff33b
Autor:
Coralie Dorard, Claire Madry, Olivier Buhard, Stefanie Toifl, Sebastian Didusch, Toky Ratovomanana, Quentin Letourneur, Helmut Dolznig, Mathew J. Garnett, Alex Duval, Manuela Baccarini
Publikováno v:
Oncogene. 42:1649-1660
More than 30% of all human cancers are driven by RAS mutations and activating KRAS mutations are present in 40% of colorectal cancer (CRC) in the two main CRC subgroups, MSS (Microsatellite Stable) and MSI (Microsatellite Instable). Studies in RAS-dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f75ef5b397a3b1a216944e18afa23ca7
https://doi.org/10.1038/s41388-023-02683-w
https://doi.org/10.1038/s41388-023-02683-w
Autor:
Romain Cohen, Vincent Jonchère, Toky Ratovomanana, Quentin Letourneur, Mira Ayadi, Lucile Armenoult, Adrien Buisson, Matthieu Sarabi, Anna Pellat, Francois Paye, Alex Duval
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 2 (2021)
Metastatic colorectal cancers (mCRC) harboring microsatellite instability (MSI) are sensitive to immune checkpoint inhibitors (ICIs), but the mechanisms of resistance to ICIs remain unclear. Dissociated responses in patients with ICI-treated cancer s
Externí odkaz:
https://doaj.org/article/766e2d2ae92c46f59d17f74264f5bde7
Autor:
Vincent Jonchere, Laetitia Marisa, Malorie Greene, Alain Virouleau, Olivier Buhard, Romane Bertrand, Magali Svrcek, Pascale Cervera, Anastasia Goloudina, Erell Guillerm, Florence Coulet, Samuel Landman, Toky Ratovomanana, Sylvie Job, Mira Ayadi, Nabila Elarouci, Lucile Armenoult, Fatiha Merabtene, Sylvie Dumont, Yann Parc, Jérémie H. Lefèvre, Thierry André, Jean-François Fléjou, Agathe Guilloux, Ada Collura, Aurélien de Reyniès, Alex Duval
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 6, Iss 3, Pp 277-300 (2018)
Background & Aims: Recent studies have shown that cancers arise as a result of the positive selection of driver somatic events in tumor DNA, with negative selection playing only a minor role, if any. However, these investigations were concerned with
Externí odkaz:
https://doaj.org/article/db668905d34649de97e087d79ac84a22
Autor:
Roseline Vibert, Jasmine Hasnaoui, Alexandre Perrier, Alexandra Lefebvre, Chrystelle Colas, Marion Dhooge, Noémie Basset, Albain Chansavang, Camille Desseignes, Alex Duval, Solenne Farelly, Nadim Hamzaoui, Pierre Laurent-Puig, Julie Metras, Diane Moliere, Martine Muleris, Jeanne Netter, Mehdi Touat, Franck Bielle, Karim Labreche, Romain Nicolle, Géraldine Perkins, Mathilde Warcoin, Florence Coulet, Patrick R. Benusiglio
Publikováno v:
European Journal of Human Genetics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8921497eb9c1a0e245ce99245c188f25
https://doi.org/10.1038/s41431-023-01367-z
https://doi.org/10.1038/s41431-023-01367-z
Autor:
Raphael Colle, Sara Lonardi, Marine Cachanado, Michael J Overman, Elena Elez, Marwan Fakih, Francesca Corti, Priya Jayachandran, Magali Svrcek, Antoine Dardenne, Baptiste Cervantes, Alex Duval, Romain Cohen, Filippo Pietrantonio, Thierry André
Publikováno v:
The Oncologist.
Background We pooled data from 2 cohorts of immune checkpoint inhibitors-treated microsatellite instability-high/mismatch repair-deficient (MSI/dMMR) metastatic colorectal cancer patients to evaluate the prognostic value of RAS/BRAFV600E mutations an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c88f6e7935ab7dc17c08dd5aa8b426a6
https://doi.org/10.1093/oncolo/oyad082
https://doi.org/10.1093/oncolo/oyad082
Autor:
Pierre Laurent-Puig, Aurélien de Reyniès, Jean-François Emile, Valérie Boige, Sophie Mouillet-Richard, Janick Selves, Audrey Rapinat, David Gentien, Valérie Taly, Hélène Blons, Alex Duval, Daniela Aust, Ramon Salazar, Côme Lepage, Karine Le Malicot, Camilla Pilati, Mira Ayadi, Julien Taieb, Yuna Blum, Laetitia Marisa
Purpose:The consensus molecular subtypes (CMS) represent a significant advance in the understanding of intertumor heterogeneity in colon cancer. Intratumor heterogeneity (ITH) is the new frontier for refining prognostication and understanding treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07922256faee29c30686d1abc1b7335b
https://doi.org/10.1158/1078-0432.c.6530403
https://doi.org/10.1158/1078-0432.c.6530403
Autor:
Pierre Laurent-Puig, Aurélien de Reyniès, Jean-François Emile, Valérie Boige, Sophie Mouillet-Richard, Janick Selves, Audrey Rapinat, David Gentien, Valérie Taly, Hélène Blons, Alex Duval, Daniela Aust, Ramon Salazar, Côme Lepage, Karine Le Malicot, Camilla Pilati, Mira Ayadi, Julien Taieb, Yuna Blum, Laetitia Marisa
supplementary data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::443000be778a72a58dd46e3d5e55b5e6
https://doi.org/10.1158/1078-0432.22480257.v1
https://doi.org/10.1158/1078-0432.22480257.v1
Autor:
Roseline VIBERT, Jasmine Hasnaoui, Alexandra Lefebvre, Chrystelle Colas, Marion Dhooge, Noemie Basset, Albain Chansavang, Camille Desseignes, Alex Duval, Solenne Farelly, Nadim Hamzaoui, Pierre Laurent-Puig, Julie Metras, Diane Moliere, Martine Muleris, Jeanne Netter, Romain Nicolle, Géraldine Perkins, Alexandre Perrier, Mathilde Warcoin, Florence Coulet, Patrick Benusiglio
Some patients with Lynch syndrome (LS) have extreme phenotypes, i.e. cancer before the recommended screening age, or cancer for which there are no screening guidelines. We made the hypothesis that additional germline variants in cancer susceptibility
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a37a87cafff94066f032af60c65ae91
https://doi.org/10.21203/rs.3.rs-2159229/v1
https://doi.org/10.21203/rs.3.rs-2159229/v1