Weak to no correlation between quantitative high-resolution computed tomography metrics and lung function change in fibrotic diseases

Autor: Yixuan Zou, Xuefeng Hou, Neha Anegondi, Mohammadreza Negahdar, Dorothy Cheung, Paula Belloni, Alex de Crespigny, Alexandre Fernandez Coimbra

Publikováno v: ERJ Open Research, Vol 9, Iss 5 (2023)

Background Identifying systemic sclerosis (SSc) and idiopathic pulmonary fibrosis (IPF) patients at risk of more rapid forced vital capacity (FVC) decline could improve trial design. The purpose of the present study was to explore the prognostic valu

Externí odkaz: https://doaj.org/article/df885346bb274c64b06723dd75925756

Heart and bladder detection and segmentation on FDG PET/CT by deep learning

Autor: Xiaoyong Wang, Skander Jemaa, Jill Fredrickson, Alexandre Fernandez Coimbra, Tina Nielsen, Alex De Crespigny, Thomas Bengtsson, Richard A. D. Carano

Publikováno v: BMC Medical Imaging, Vol 22, Iss 1, Pp 1-13 (2022)

Abstract Purpose Positron emission tomography (PET)/ computed tomography (CT) has been extensively used to quantify metabolically active tumors in various oncology indications. However, FDG-PET/CT often encounters false positives in tumor detection d

Externí odkaz: https://doaj.org/article/04aad2d3ad564c558ae667f831f4c02a

Resting-state functional magnetic resonance imaging in a randomized clinical trial for Alzheimer's disease

Autor: David Clayton, Alexandre Coimbra, Farshid Faraji, Thomas Bengtsson, Lee Honigberg, William Cho, Robert Paul, Alex de Crespigny

Publikováno v: Neuroimage: Reports, Vol 1, Iss 4, Pp 100055- (2021)

Resting-state functional connectivity has been used to study Alzheimer's disease, revealing underlying differences between groups of individuals at different levels of cognitive impairment, or groupwise changes over time. Most of these studies have e

Externí odkaz: https://doaj.org/article/0385cf08fb4d43de8c03a5d982256ba0

Preclinical development of ZED8, an

Autor: Annie, Ogasawara, James R, Kiefer, Herman, Gill, Eugene, Chiang, Shravan, Sriraman, Gregory Z, Ferl, James, Ziai, Sandra Sanabria, Bohorquez, Sebastian, Guelman, Xiangdan, Wang, Jihong, Yang, Minh Michael, Phan, Van, Nguyen, Shan, Chung, Christine, Yu, Jeff, Tinianow, Stijn Jan Hein, Waaijer, Alex, De Crespigny, Jan, Marik, C Andrew, Boswell, Tanja, Zabka, Karin, Staflin, Simon-Peter, Williams

Publikováno v: European journal of nuclear medicine and molecular imaging. 50(2)

ZED8 is a novel monovalent antibody labeled with zirconium-89 for the molecular imaging of CD8. This work describes nonclinical studies performed in part to provide rationale for and to inform expectations in the early clinical development of ZED8, s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::31e464b63e7f56aaa5305457496e7b95
https://pubmed.ncbi.nlm.nih.gov/36427067

Magnetic Resonance Enterography and Histology in Patients With Fibrostenotic Crohn's Disease: A Multicenter Study

Autor: Alexandre Coimbra, Jordi Rimola, Miriam Cuatrecasas, Gert De Hertogh, Gert Van Assche, Ragna Vanslembrouck, Henning Glerup, Agnete Hedemann Nielsen, Rikke Hagemann-Madsen, Yoram Bouhnik, Magaly Zappa, Dominique Cazals-Hatem, Geert D'Haens, Jaap Stoker, Sybren Meijer, Gerhard Rogler, Andreas Boss, Achim Weber, Rui Zhao, Mary E. Keir, Alexis Scherl, Alex de Crespigny, Timothy T. Lu, Julián Panés

Publikováno v: Coimbra, A, Rimola, J, Cuatrecasas, M, De Hertogh, G, Van Assche, G, Vanslembrouck, R, Glerup, H, Nielsen, A H, Hagemann-Madsen, R, Bouhnik, Y, Zappa, M, Cazals-Hatem, D, D'Haens, G, Stoker, J, Meijer, S, Rogler, G, Boss, A, Weber, A, Zhao, R, Keir, M E, Scherl, A, de Crespigny, A, Lu, T T & Panés, J 2022, ' Magnetic Resonance Enterography and Histology in Patients With Fibrostenotic Crohn's Disease : A Multicenter Study ', Clinical and Translational Gastroenterology, vol. 13, no. 7, e00505 . https://doi.org/10.14309/ctg.0000000000000505
Coimbra, A, Rimola, J, Cuatrecasas, M, de Hertogh, G, van Assche, G, Vanslembrouck, R, Glerup, H, Nielsen, A H, Hagemann-Madsen, R, Bouhnik, Y, Zappa, M, Cazals-Hatem, D, D'Haens, G, Stoker, J, Meijer, S, Rogler, G, Boss, A, Weber, A, Zhao, R, Keir, M E, Scherl, A, de Crespigny, A, Lu, T T & Panés, J 2022, ' Magnetic Resonance Enterography and Histology in Patients With Fibrostenotic Crohn's Disease : A Multicenter Study ', CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY, vol. 13, no. 7, pp. e00505 . https://doi.org/10.14309/ctg.0000000000000505
Clinical and translational gastroenterology, 13(7). Nature Publishing Group
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY, 13(7). Nature Publishing Group

INTRODUCTION: Magnetic resonance enterography (MRE) is useful for detecting bowel strictures, whereas a number of imaging biomarkers may reflect severity of fibrosis burden in Crohn's disease (CD). This study aimed to verify the association of MRE me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2e7b36f148a23fc90cd9aa8a6d29b0