Výsledky vyhledávání - "Alex, Carisey"

Lenalidomide augments actin remodeling and lowers NK-cell activation thresholds

Autor: Rajesh Chopra, David H. J. Morgan, Kathryn Lagrue, Alex Carisey, Daniel M. Davis

Publikováno v: Lagrue, K, Carisey, A, Morgan, D J, Chopra, R & Davis, D M 2015, ' Lenalidomide augments actin remodelling and lowers NK cell activation thresholds. ', Blood, vol. 126, no. 1, pp. 50-60 . https://doi.org/10.1182/blood-2015-01-625004

As multiple myeloma (MM) progresses, natural killer (NK)-cell responses decline against malignant plasma cells. The immunomodulatory drug lenalidomide is widely used for treatment of MM but its influence on NK-cell biology is unclear. Here, we report

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e42356867e02107b2b4bea8a4eafe45
https://doi.org/10.1182/blood-2015-01-625004

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Combining AFM and Acoustic Probes to Reveal Changes in the Elastic Stiffness Tensor of Living Cells

Autor: Nadja Nijenhuis, Christoph Ballestrem, Alex Carisey, Xuegen Zhao, Brian Derby

Knowledge of how the elastic stiffness of a cell affects its communication with its environment is of fundamental importance for the understanding of tissue integrity in health and disease. For stiffness measurements, it has been customary to quote a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90dc0ddbc856cac18e9e2b7b0f3d929c
https://europepmc.org/articles/PMC4190602/

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Global analysis reveals the complexity of the human glomerular extracellular matrix

Autor: Rachel, Lennon, Adam, Byron, Jonathan D, Humphries, Michael J, Randles, Alex, Carisey, Stephanie, Murphy, David, Knight, Paul E, Brenchley, Roy, Zent, Martin J, Humphries

Publikováno v: Journal of the American Society of Nephrology : JASN. 25(5)

The glomerulus contains unique cellular and extracellular matrix (ECM) components, which are required for intact barrier function. Studies of the cellular components have helped to build understanding of glomerular disease; however, the full composit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::840fe0799b4be269c0406768a5f69328
https://pubmed.ncbi.nlm.nih.gov/24436468

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The central role of the cytoskeleton in mechanisms and functions of the NK cell immune synapse

Autor: David Williamson, Adam N.R. Cartwright, Alex Carisey, Charlotte Barthen, Daniel M. Davis, Philippa R. Kennedy, Anna Oszmiana, Kathryn Lagrue

Publikováno v: Immunological reviews. 256(1)

Natural killer (NK) cells discriminate between healthy and unhealthy target cells through a balance of activating and inhibitory signals at direct intercellular contacts called immune synapses. Rearrangements in the cellular cytoskeleton have long be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81a5a552ccd51bf1be6635210adfd540
https://pubmed.ncbi.nlm.nih.gov/24117823

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Fluorescence recovery after photobleaching

Autor: Alex, Carisey, Matthew, Stroud, Ricky, Tsang, Christoph, Ballestrem

Publikováno v: Methods in molecular biology (Clifton, N.J.). 769

This chapter describes the use of microscope-based fluorescence recovery after photobleaching (FRAP). To quantify the dynamics of proteins within a subcellular compartment, we first outline the general aspects of FRAP experiments and then provide a d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6013a3701d3b66b37b01a8e5d5e7349d
https://pubmed.ncbi.nlm.nih.gov/21748690

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