Modulation of Antimalarial Activity at a Putative Bisquinoline Receptor in vivo Using Fluorinated Bisquinolines

Autor: Said Alizadeh-Shekalgourabi, Sam P. de Visser, James F. Dunn, Alistair J. Fielding, Michael G. B. Drew, Fyaz M.D. Ismail, Fabián G. Cantú Reinhard, Alessio del Casino, Nicola M. Dempster, Philip G. Evans, Verity Male, Dascombe Mj, Valentina Lukinović, Roger H. Bisby, Lutfun Nahar, Satyajit D. Sarker, Laura E. Randle

Publikováno v: Fielding, A, Lukinović, V, Evans, P G, Alizadeh-Shekalgourabi, S, Bisby, R H, Drew, M G B, ADel Casino, A, Dunn, J F, Randle, L E, Dempster, N M, Nahar, L, Sarker, S D, Cantu Reinhard, F, De Visser, S, Dascombe, M & Ismail, F M D 2017, ' Modulation of Antimalarial Activity at a Putative Bisquinoline Receptor in vivo Using Fluorinated Bisquinolines ', Chemistry: A European Journal, vol. 23, no. 28, pp. 6811-6828 . https://doi.org/10.1002/chem.201605099

Antimalarials can interact with heme covalently, by π⋅⋅⋅π interactions or by hydrogen bonding. Consequently, the prototropy of 4-aminoquinolines and quinoline methanols was investigated by using quantum mechanics. Calculations showed mefloqui

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