Gametocyte-specific and all-blood-stage transmission-blocking chemotypes discovered from high throughput screening on Plasmodium falciparum gametocytes

Autor: Giacomo Paonessa, Giulia Siciliano, Rita Graziani, Cristiana Lalli, Ottavia Cecchetti, Cristina Alli, Roberto La Valle, Alessia Petrocchi, Alessio Sferrazza, Monica Bisbocci, Mario Falchi, Carlo Toniatti, Alberto Bresciani, Pietro Alano

Publikováno v: Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)

High-throughput screening of 120,000 compounds followed by counter-screening and validation assays reveals candidate antimalarial drugs that kill Plasmodium falciparum sexual and asexual blood stages blocking parasite transmission through mosquito.

Externí odkaz: https://doaj.org/article/59fe7c35684348d7a872e3a5b86d2bef

Highly Efficient and Mild Gold (I) Catalyzed Synthesis of 3,8-Diarylidene-2,7-dioxaspiro[4.4]nonane-1,6-diones

Autor: Antonia Iazzetti, Dario Allevi, Andrea Calcaterra, Giancarlo Fabrizi, Antonella Goggiamani, Giulia Mazzoccanti, Alessio Sferrazza, Rosanna Verdiglione, Valeria Vergine

Publikováno v: Molecules, Vol 28, Iss 1, p 300 (2022)

The gold-catalyzed cyclization of 2,2-bis(3-arylprop-2-yn1-yl)malonic acid has been proposed as an efficient approach to substituted 3,8-dibenzyl-2,7-dioxaspiro[4.4]nonane-1,6-diones. The reaction proceeds smoothly in mild reaction conditions to give

Externí odkaz: https://doaj.org/article/4b5a7351ca5b4c988ff8acac65fedab9

Discovery of a Novel Series of Imidazopyrazine Derivatives as Potent SHP2 Allosteric Inhibitors

Autor: Esther Torrente, Valentina Fodale, Alina Ciammaichella, Federica Ferrigno, Jesus M. Ontoria, Simona Ponzi, Ilaria Rossetti, Alessio Sferrazza, Jérôme Amaudrut, Antonino Missineo, Simone Esposito, Simone Palombo, Martina Nibbio, Mauro Cerretani, Monica Bisbocci, Antonella Cellucci, Annalise di Marco, Cristina Alli, Vincenzo Pucci, Carlo Toniatti, Alessia Petrocchi

Publikováno v: ACS Medicinal Chemistry Letters. 14:156-162

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6897f93fa03f3115ac19fe47da452c3
https://doi.org/10.1021/acsmedchemlett.2c00454

Azide-free synthesis of Boc-protected (3R,4S)-3,4-dihydroxypiperidine

Autor: Paola Fezzardi, Danilo Fabbrini, Nicola Relitti, Federica Ferrigno, Ilaria Rossetti, Alessio Sferrazza, Alessia Petrocchi, Christian Montalbetti

Publikováno v: Tetrahedron Letters. 97:153789

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a3477c64bc8dcf7c47de5b0851bbc02
https://doi.org/10.1016/j.tetlet.2022.153789

Synthesis and Small and Wide Angle X-Ray Scattering Characterization of L-Proline Based Chiral Ionic Liquids

Autor: Alessandro Triolo, Ruggero Caminiti, Luisa Maria Migneco, Alessio Sferrazza

Publikováno v: Current organic chemistry 19 (2015): 99–104. doi:10.2174/1385272819666141211221640
info:cnr-pdr/source/autori:Sferrazza, Alessio; Triolo, Alessandro; Migneco, Luisa M.; Caminiti, Ruggero/titolo:Synthesis and Small and Wide Angle X-Ray Scattering Characterization of L-Proline Based Chiral Ionic Liquids/doi:10.2174%2F1385272819666141211221640/rivista:Current organic chemistry/anno:2015/pagina_da:99/pagina_a:104/intervallo_pagine:99–104/volume:19
Scopus-Elsevier

In this work we report the first small and wide-angle X-Ray diffraction study (S-WAXS) of L-proline ester based ionic liquids, a family of chiral ionic liquids (CILs) with several potential useful applications. Along the synthetic pathway that was fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fe4bda3c062cec4fbbebb3c6e06dfde
https://doi.org/10.2174/1385272819666141211221640