Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Alessio Lanna"'
Autor:
Inès Dufait, Therese Liechtenstein, Alessio Lanna, Christopher Bricogne, Roberta Laranga, Antonella Padella, Karine Breckpot, David Escors
Publikováno v:
Scientifica, Vol 2012 (2012)
Retroviral and lentiviral vectors have proven to be particularly efficient systems to deliver genes of interest into target cells, either in vivo or in cell cultures. They have been used for some time for gene therapy and the development of gene vacc
Externí odkaz:
https://doaj.org/article/6e07370133f54efe9b873b01b2905146
Autor:
Alessio Lanna, Clara D’Ambra
Publikováno v:
The Immune Synapse ISBN: 9781071631348
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a241afff535a1d7b4b691231206d38f
https://doi.org/10.1007/978-1-0716-3135-5_16
https://doi.org/10.1007/978-1-0716-3135-5_16
Autor:
Bruno Vaz, Salvatore Valvo, Francesco Maria Esposito, Giovanna Borsellino, Alessio Lanna, Claudia Vuotto, Clara D’Ambra, Derek W. Gilroy, Michael Karin, Massimo Sanchez, Arne N. Akbar, Valerio Chiurchiù, Michael L. Dustin, Oliver P. Devine
The common view is that T-lymphocytes activate telomerase, a DNA polymerase that extends telomeres at chromosome ends, to delay senescence. We show that independently of telomerase, T cells elongate telomeres by acquiring telomere vesicles from antig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cb19911f1e0b3502e932394baddeed2
https://doi.org/10.1101/2020.10.09.331918
https://doi.org/10.1101/2020.10.09.331918
Autor:
Alessio Lanna, Bruno Vaz, Clara D’Ambra, Salvatore Valvo, Claudia Vuotto, Valerio Chiurchiù, Oliver Devine, Massimo Sanchez, Giovanna Borsellino, Arne N. Akbar, Marco De Bardi, Derek W. Gilroy, Michael L. Dustin, Brendan Blumer, Michael Karin
Publikováno v:
Nature cell biology. 24(10)
The common view is that T lymphocytes activate telomerase to delay senescence. Here we show that some T cells (primarily naïve and central memory cells) elongated telomeres by acquiring telomere vesicles from antigen-presenting cells (APCs) independ
Autor:
Djamel Nehar-Belaid, Alessio Lanna, Daniel Cláudio de Oliveira Gomes, Emma S. Chambers, Anis Larbi, Luciana Polaco Covre, Radu Marches, Jun Hee Lee, Mala K. Maini, Neil A. Mabbott, Jessica Strid, Sam M. Janes, Arne N. Akbar, Sian M. Henson, Derek W. Gilroy, Vitor H. Teixeira, Branca Pereira, Jacques Banchereau, Duygu Ucar, Natalie E. Riddell, Roel P.H. De Maeyer, George A. Kuchel, Sophie Ward
Publikováno v:
Nat Immunol
Pereira, B I, De Maeyer, R P H, Covre, L P, Nehar-Belaid, D, Lanna, A, Ward, S, Marches, R, Chambers, E S, Gomes, D C O, Riddell, N E, Maini, M K, Teixeira, V H, Janes, S M, Gilroy, D W, Larbi, A, Mabbott, N, Ucar, D, Kuchel, G A, Henson, S M, Strid, J, Lee, J H, Banchereau, J & Akbar, A N 2020, ' Sestrins induce natural killer function in senescent-like CD8+ T cells ', Nature Immunology . https://doi.org/10.1038/s41590-020-0643-3
Pereira, B I, De Maeyer, R P H, Covre, L P, Nehar-Belaid, D, Lanna, A, Ward, S, Marches, R, Chambers, E S, Gomes, D C O, Riddell, N E, Maini, M K, Teixeira, V H, Janes, S M, Gilroy, D W, Larbi, A, Mabbott, N, Ucar, D, Kuchel, G A, Henson, S M, Strid, J, Lee, J H, Banchereau, J & Akbar, A N 2020, ' Sestrins induce natural killer function in senescent-like CD8+ T cells ', Nature Immunology . https://doi.org/10.1038/s41590-020-0643-3
Ageing is associated with re-modelling of the immune system to enable the maintenance of life-long immunity. In the CD8(+) T cell compartment, ageing results in the expansion of highly-differentiated cells that exhibit characteristics of cellular sen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::289e8fffe8d05399b0c4afbc6fd159d2
http://hdl.handle.net/10044/1/84728
http://hdl.handle.net/10044/1/84728
Autor:
Thomas McDonnell, Bojana Müller-Durovic, Michael Karin, Arne N. Akbar, Jun Hee Lee, Alessio Lanna, David Escors, Daniel Cláudio de Oliveira Gomes, Derek W. Gilroy
Publikováno v:
Nature immunology
Mitogen-activated protein kinases (MAPKs) including Erk, Jnk and p38 regulate diverse cellular functions and are thought to be controlled by independent upstream activation cascades. Here we show that the sestrins bind to and coordinate simultaneous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::debfa5855197430411f26e5a81239b93
https://doi.org/10.1038/ni.3665
https://doi.org/10.1038/ni.3665
Autor:
Alessio Lanna
Publikováno v:
Methods in Molecular Biology ISBN: 9781493965465
Telomerase, a RNA-dependent DNA polymerase that adds telomeric DNA at the 3′ ends of eukaryotic chromosomes, is essential for the lifelong preservation of the proliferative potential of antigen specific T lymphocytes. However, senescent T cells tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b97b3947bde7126772958cd727a8f678
https://ora.ox.ac.uk/objects/uuid:7ffed93c-25b5-4025-9cb2-345a434e978c
https://ora.ox.ac.uk/objects/uuid:7ffed93c-25b5-4025-9cb2-345a434e978c
Autor:
Alessio, Lanna
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1514
Telomerase, a RNA-dependent DNA polymerase that adds telomeric DNA at the 3' ends of eukaryotic chromosomes, is essential for the lifelong preservation of the proliferative potential of antigen specific T lymphocytes. However, senescent T cells that
Publikováno v:
Trends in Immunology. 37(12)
As humans live longer, a central concern is to find ways to maintain their health as they age. Immunity declines during ageing, as shown by the increased susceptibility to infection by both previously encountered and new pathogens and by the decrease
In T lymphocytes, the mitogen-activated protein kinase (MAPK) p38 regulates pleiotropic functions and is activated by canonical MAPK signaling or the alternative activation pathway downstream of the T cell antigen receptor (TCR). Here we found that s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::807c79e2595cffb4025b598072dd41e9
https://ora.ox.ac.uk/objects/uuid:b7b0a355-f100-45ef-a3e0-45dd72eb4bbe
https://ora.ox.ac.uk/objects/uuid:b7b0a355-f100-45ef-a3e0-45dd72eb4bbe