Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Alessio Fiascarelli"'
Autor:
Elena M. Tosca, Elisa Borella, Chiara Piana, Salim Bouchene, Giuseppe Merlino, Alessio Fiascarelli, Paolo Mazzei, Paolo Magni
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 11, Pp 1626-1639 (2023)
Abstract MEN1611 is a novel orally bioavailable PI3K inhibitor currently in clinical development for patients with HER2‐positive (HER2+) PI3KCA mutated advanced/metastatic breast cancer (BC) in combination with trastuzumab (TZB). In this work, a tr
Externí odkaz:
https://doaj.org/article/dba562be02ea4a66a04c13114df44563
Autor:
Eugenio Gaudio, Chiara Tarantelli, Filippo Spriano, Francesca Guidetti, Giulio Sartori, Roberta Bordone, Alberto J. Arribas, Luciano Cascione, Mario Bigioni, Giuseppe Merlino, Alessio Fiascarelli, Alessandro Bressan, Afua Adjeiwaa Mensah, Gaetanina Golino, Renzo Lucchini, Elena Bernasconi, Davide Rossi, Emanuele Zucca, Georg Stussi, Anastasios Stathis, Robert S. Boyd, Rachel L. Dusek, Arnima Bisht, Nickolas Attanasio, Christian Rohlff, Andrea Pellacani, Monica Binaschi, Francesco Bertoni
Publikováno v:
Haematologica, Vol 105, Iss 11 (2020)
Antibody drug conjugates represent an important class of anti-cancer drugs in both solid tumors and hematological cancers. Here, we report preclinical data on the anti-tumor activity of the first-in-class antibody drug conjugate MEN1309/OBT076 target
Externí odkaz:
https://doaj.org/article/fd52bf5cbc7f444ba1538b1b0e104dc7
Autor:
Alessio Fiascarelli, Giuseppe Merlino, Stefania Capano, Simone Talucci, Diego Bisignano, Alessandro Bressan, Daniela Bellarosa, Corrado Carrisi, Alessandro Paoli, Mario Bigioni, Patrizia Tunici, Clelia Irrissuto, Massimiliano Salerno, Joaquin Arribas, Elisa de Stanchina, Maurizio Scaltriti, Monica Binaschi
Publikováno v:
Scientia
Purpose Dysregulation of the PI3K pathway is one of the most common events in breast cancer. Here we investigate the activity of the PI3K inhibitor MEN1611 at both molecular and phenotypic levels by dissecting and comparing its profile and efficacy i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106976cb77db0f365733f8e2231bb9ed
https://hdl.handle.net/11351/9983
https://hdl.handle.net/11351/9983
Autor:
Monica Binaschi, Andrea Pellacani, Stefano Manzini, Christian Rohlff, Keith E. Wilson, Jonathan Terrett, Carmel M. Lynch, Michael Trang, Dee Aud, Rahel Awdew, Phuoc Huy Pham, James E. Ackroyd, Rachel L. Dusek, San Lin Lou, Nickolas Attanasio, Sudha Swaminathan, Uyen T. Do, Robert Boyd, Angelo Kaplan, Arnima Bisht, Joaquin Arribas, Cristina Bernadó Morales, Rosanna Manno, Rossana Bugianesi, Massimiliano Salerno, Daniela Bellarosa, Corrado Carrisi, Alessandro Bressan, Mario Bigioni, Alessio Fiascarelli, Giuseppe Merlino
Supplementary Table S5: Microscopic IHC staining for CD205 in different cynomolgus tissues after treatment with MEN1309/OBT076. Staining: 1, minimal (+, rare cells with low staining intensity); 2, slight/moderate (++, many cells with medium/high stai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d120dff76a7a69bed3c4755b84293b6
https://doi.org/10.1158/1535-7163.22506909.v1
https://doi.org/10.1158/1535-7163.22506909.v1
Autor:
Monica Binaschi, Andrea Pellacani, Stefano Manzini, Christian Rohlff, Keith E. Wilson, Jonathan Terrett, Carmel M. Lynch, Michael Trang, Dee Aud, Rahel Awdew, Phuoc Huy Pham, James E. Ackroyd, Rachel L. Dusek, San Lin Lou, Nickolas Attanasio, Sudha Swaminathan, Uyen T. Do, Robert Boyd, Angelo Kaplan, Arnima Bisht, Joaquin Arribas, Cristina Bernadó Morales, Rosanna Manno, Rossana Bugianesi, Massimiliano Salerno, Daniela Bellarosa, Corrado Carrisi, Alessandro Bressan, Mario Bigioni, Alessio Fiascarelli, Giuseppe Merlino
Supplementary Figure S3-A. Representative image of IHC staining for CD205 in a tumor mass from HCC-70 xenograft model, 16 days far from the initial treatment with 5 mg/kg of MEN1309/OBT076. The semiquantitative IHC analysis showed a score of 1+ in 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::409b3e8ea4192c7e05c7ae7eb15f6146
https://doi.org/10.1158/1535-7163.22506918
https://doi.org/10.1158/1535-7163.22506918
Autor:
Monica Binaschi, Andrea Pellacani, Stefano Manzini, Christian Rohlff, Keith E. Wilson, Jonathan Terrett, Carmel M. Lynch, Michael Trang, Dee Aud, Rahel Awdew, Phuoc Huy Pham, James E. Ackroyd, Rachel L. Dusek, San Lin Lou, Nickolas Attanasio, Sudha Swaminathan, Uyen T. Do, Robert Boyd, Angelo Kaplan, Arnima Bisht, Joaquin Arribas, Cristina Bernadó Morales, Rosanna Manno, Rossana Bugianesi, Massimiliano Salerno, Daniela Bellarosa, Corrado Carrisi, Alessandro Bressan, Mario Bigioni, Alessio Fiascarelli, Giuseppe Merlino
Supplementary Figure S2. In vitro characterization of MEN1309/OBT076. A) ELISA assay showed that both the unconjugated and DM4-conjugated antibodies were able to bind FcγRIIIA with the same affinity (n=2). B) FACS binding experiment on THP-1 cell li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aefead13cb4ceb92f11fcd09e2c2c30
https://doi.org/10.1158/1535-7163.22506921.v1
https://doi.org/10.1158/1535-7163.22506921.v1
Autor:
Monica Binaschi, Andrea Pellacani, Stefano Manzini, Christian Rohlff, Keith E. Wilson, Jonathan Terrett, Carmel M. Lynch, Michael Trang, Dee Aud, Rahel Awdew, Phuoc Huy Pham, James E. Ackroyd, Rachel L. Dusek, San Lin Lou, Nickolas Attanasio, Sudha Swaminathan, Uyen T. Do, Robert Boyd, Angelo Kaplan, Arnima Bisht, Joaquin Arribas, Cristina Bernadó Morales, Rosanna Manno, Rossana Bugianesi, Massimiliano Salerno, Daniela Bellarosa, Corrado Carrisi, Alessandro Bressan, Mario Bigioni, Alessio Fiascarelli, Giuseppe Merlino
Supplementary Table S1. Commercial tumor TMAs representing different solid tumor types. Supplementary Table S2. Summary of CD205 expression in human solid tumor types.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21cf7101ed534f43774d52ecead68615
https://doi.org/10.1158/1535-7163.22506906
https://doi.org/10.1158/1535-7163.22506906
Autor:
Monica Binaschi, Andrea Pellacani, Stefano Manzini, Christian Rohlff, Keith E. Wilson, Jonathan Terrett, Carmel M. Lynch, Michael Trang, Dee Aud, Rahel Awdew, Phuoc Huy Pham, James E. Ackroyd, Rachel L. Dusek, San Lin Lou, Nickolas Attanasio, Sudha Swaminathan, Uyen T. Do, Robert Boyd, Angelo Kaplan, Arnima Bisht, Joaquin Arribas, Cristina Bernadó Morales, Rosanna Manno, Rossana Bugianesi, Massimiliano Salerno, Daniela Bellarosa, Corrado Carrisi, Alessandro Bressan, Mario Bigioni, Alessio Fiascarelli, Giuseppe Merlino
CD205 is a type I transmembrane glycoprotein and is a member of the C-type lectin receptor family. Analysis by mass spectrometry revealed that CD205 was robustly expressed and highly prevalent in a variety of solid malignancies from different histoty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15a43cd253373afbccb5590a5dc6f77f
https://doi.org/10.1158/1535-7163.c.6538521.v1
https://doi.org/10.1158/1535-7163.c.6538521.v1
Autor:
Monica Binaschi, Andrea Pellacani, Stefano Manzini, Christian Rohlff, Keith E. Wilson, Jonathan Terrett, Carmel M. Lynch, Michael Trang, Dee Aud, Rahel Awdew, Phuoc Huy Pham, James E. Ackroyd, Rachel L. Dusek, San Lin Lou, Nickolas Attanasio, Sudha Swaminathan, Uyen T. Do, Robert Boyd, Angelo Kaplan, Arnima Bisht, Joaquin Arribas, Cristina Bernadó Morales, Rosanna Manno, Rossana Bugianesi, Massimiliano Salerno, Daniela Bellarosa, Corrado Carrisi, Alessandro Bressan, Mario Bigioni, Alessio Fiascarelli, Giuseppe Merlino
Supplementary Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eec59be317dbf0230532db78f737319
https://doi.org/10.1158/1535-7163.22506927
https://doi.org/10.1158/1535-7163.22506927
Autor:
Elena M. Tosca, Elisa Borella, Chiara Piana, Salim Bouchene, Giuseppe Merlino, Alessio Fiascarelli, Paolo Mazzei, Paolo Magni
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology.