Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Alessio De Magis"'
TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest
Autor:
Alessio De Magis, Philipp Schult, Antonia Schönleber, Rebecca Linke, Kerstin U. Ludwig, Beate M. Kümmerer, Katrin Paeschke
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Background SARS-CoV-2 infection depends on the host cell factors angiotensin-converting enzyme 2, ACE2, and the transmembrane serinprotease 2, TMPRSS2. Potential inhibitors of these proteins would be ideal targets against severe acute respir
Externí odkaz:
https://doaj.org/article/482e5826db224a729a72cbb3f46861e9
Autor:
Alessio De Magis, Michaela Limmer, Venkat Mudiyam, David Monchaud, Stefan Juranek, Katrin Paeschke
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Senescence has two roles in oncology: it is known as a potent tumor-suppressive mechanism, which also supports tissue regeneration and repair, it is also known to contribute to reduced patient resilience, which might lead to cancer recurrenc
Externí odkaz:
https://doaj.org/article/6587942841c340699a216b4c762cb0e3
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-12 (2021)
Abstract Background Nucleic acids can fold into non-canonical secondary structures named G-quadruplexes (G4s), which consist of guanine-rich sequences stacked into guanine tetrads stabilized by Hoogsteen hydrogen bonding, π-π interactions, and mono
Externí odkaz:
https://doaj.org/article/434443b8e28f4375a881de111208c1f0
Autor:
Alessio De Magis, Silvia Götz, Mona Hajikazemi, Enikő Fekete-Szücs, Marco Caterino, Stefan Juranek, Katrin Paeschke
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
G4 structure-interacting proteins have been linked to DNA repair processes. Here the authors reveal that in yeast, Zuo1 associates with G4 structures and plays a role in repair pathway choice by promoting nucleotide excision repair and ultimately con
Externí odkaz:
https://doaj.org/article/cd23c2b5cefd458695c086739126cc02
Autor:
Joel C. Rosenbaum, Braulio Bonilla, Sarah R. Hengel, Tony M. Mertz, Benjamin W. Herken, Hinke G. Kazemier, Catherine A. Pressimone, Timothy C. Ratterman, Ellen MacNary, Alessio De Magis, Youngho Kwon, Stephen K. Godin, Bennett Van Houten, Daniel P. Normolle, Patrick Sung, Subha R. Das, Katrin Paeschke, Steven A. Roberts, Andrew P. VanDemark, Kara A. Bernstein
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
The homologous recombination machinery needs to be recruited at replication intermediates for accurate functioning. Here, the authors reveal that a Rad51 paralog-containing complex, called the Shu complex, recognizes and enables tolerance of predomin
Externí odkaz:
https://doaj.org/article/c959b07076c14325a2928af04c0eea82
Autor:
Markus Sauer, Stefan A. Juranek, James Marks, Alessio De Magis, Hinke G. Kazemier, Daniel Hilbig, Daniel Benhalevy, Xiantao Wang, Markus Hafner, Katrin Paeschke
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Translation efficiency can be affected by mRNA stability and secondary RNA structures. Here the authors reveal that loss of DHX36 helicase activity leads to an accumulation of translationally inactive target mRNAs with G-rich structures in untranslat
Externí odkaz:
https://doaj.org/article/c487ca0e9f33481f9ed1636cdf7e8cc9
Autor:
Daniel Hilbig, James Marks, Markus Hafner, Katrin Paeschke, Hinke G. Kazemier, Stefan Juranek, Xiantao Wang, Markus Sauer, Daniel Benhalevy, Alessio De Magis
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications, 10(1):2421. Nature Publishing Group
Nature Communications
Nature Communications, 10(1):2421. Nature Publishing Group
Nature Communications
Translation efficiency can be affected by mRNA stability and secondary structures, including G-quadruplex structures (G4s). The highly conserved DEAH-box helicase DHX36/RHAU resolves G4s on DNA and RNA in vitro, however a systems-wide analysis of DHX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19878510a1638c37ddc77898057fdf9b
http://link.springer.com/article/10.1038/s41467-019-10432-5
http://link.springer.com/article/10.1038/s41467-019-10432-5
Autor:
Marco Russo, Alessio De Magis, Rita Morigi, Olivier Sordet, Jessica Marinello, Stefano G. Manzo, Giovanni Capranico
Publikováno v:
Proceedings of the National Academy of Sciences. 116:816-825
G quadruplexes (G4s) and R loops are noncanonical DNA structures that can regulate basic nuclear processes and trigger DNA damage, genome instability, and cell killing. By different technical approaches, we here establish that specific G4 ligands sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72750f5d4e9e4d55df9120b87c7a582d
https://doi.org/10.1073/pnas.1810409116
https://doi.org/10.1073/pnas.1810409116
Autor:
Alessio De Magis, Silvia Götz, Mona Hajikazemi, Enikő Fekete-Szücs, Marco Caterino, Stefan Juranek, Katrin Paeschke
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications, 11(1):3907. Nature Publishing Group
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications, 11(1):3907. Nature Publishing Group
Nucleic acids can fold into G-quadruplex (G4) structures that can fine-tune biological processes. Proteins are required to recognize G4 structures and coordinate their function. Here we identify Zuo1 as a novel G4-binding protein in vitro and in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::86d66ba4379c3eb285f9016efbe85274
https://pubmed.ncbi.nlm.nih.gov/32764578
https://pubmed.ncbi.nlm.nih.gov/32764578