Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Alessio Canovai"'
Autor:
Alessio Canovai, Pete A. Williams
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 1, Pp 41-53 (2025)
Pyrroloquinoline quinone is a quinone described as a cofactor for many bacterial dehydrogenases and is reported to exert an effect on metabolism in mammalian cells/tissues. Pyrroloquinoline quinone is present in the diet being available in foodstuffs
Externí odkaz:
https://doaj.org/article/8d3f6a9b19014f6da82ca259e018a949
Autor:
James R. Tribble, Melissa Jöe, Carmine Varricchio, Amin Otmani, Alessio Canovai, Baninia Habchi, Evangelia Daskalakis, Romanas Chaleckis, Andrea Loreto, Jonathan Gilley, Craig E. Wheelock, Gauti Jóhannesson, Raymond C. B. Wong, Michael P. Coleman, Andrea Brancale, Pete A. Williams
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Maintenance of NAD pools is critical for neuronal survival. The capacity to maintain NAD pools declines in neurodegenerative disease. We identify that low NMNAT2, the critical neuronal NAD producing enzyme, drives retinal susceptibility to n
Externí odkaz:
https://doaj.org/article/752e0ceae3fe4a6387d7e708ced0fe15
Autor:
James R. Tribble, Melissa Jöe, Carmine Varricchio, Amin Otmani, Alessio Canovai, Baninia Habchi, Evangelia Daskalakis, Romanas Chaleckis, Andrea Loreto, Jonathan Gilley, Craig E. Wheelock, Gauti Jóhannesson, Raymond C. B. Wong, Michael P. Coleman, Andrea Brancale, Pete A. Williams
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/26dff57e67d64561bc637003537e66aa
Autor:
Alessio Canovai, James R. Tribble, Melissa Jöe, Daniela Y. Westerlund, Rosario Amato, Ian A. Trounce, Massimo Dal Monte, Pete A. Williams
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-23 (2023)
Abstract Retinal ganglion cells are highly metabolically active requiring strictly regulated metabolism and functional mitochondria to keep ATP levels in physiological range. Imbalances in metabolism and mitochondrial mechanisms can be sufficient to
Externí odkaz:
https://doaj.org/article/9b0fb1fc29404f1ebda176ae9e7a591f
Autor:
Rosario Amato, Alberto Melecchi, Laura Pucci, Alessio Canovai, Silvia Marracci, Maurizio Cammalleri, Massimo Dal Monte, Carla Caddeo, Giovanni Casini
Publikováno v:
Cells, Vol 12, Iss 20, p 2448 (2023)
Nutraceuticals are natural substances whose anti-oxidant and anti-inflammatory properties may be used to treat retinal pathologies. Their efficacy is limited by poor bioavailability, which could be improved using nanocarriers. Lisosan G (LG), a ferme
Externí odkaz:
https://doaj.org/article/6fc08fd7fae04cfc87e666eed49e529b
Autor:
Alessio Canovai, Rosario Amato, Alberto Melecchi, Massimo Dal Monte, Dario Rusciano, Paola Bagnoli, Maurizio Cammalleri
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
In diabetic retinopathy (DR), high blood glucose drives chronic oxidative stress and inflammation that trigger alterations of the neurovascular balance finally resulting in vascular abnormalities and retinal cell death, which converge towards altered
Externí odkaz:
https://doaj.org/article/fd8844aa2aeb4a52adf08253167f699d
Autor:
Rosario Amato, Alessio Canovai, Alberto Melecchi, Salvatore Pezzino, Roberta Corsaro, Massimo Dal Monte, Dario Rusciano, Paola Bagnoli, Maurizio Cammalleri
Publikováno v:
Biomedicines, Vol 9, Iss 9, p 1177 (2021)
Light-induced retinal damage (LD) is characterized by the accumulation of reactive oxygen species leading to oxidative stress and photoreceptor cell death. The use of natural antioxidants has emerged as promising approach for the prevention of LD. Am
Externí odkaz:
https://doaj.org/article/0bc94128e88f4cb495132d564ac69d52
Autor:
Noemi Anna Pesce, Alessio Canovai, Emma Lardner, Maurizio Cammalleri, Anders Kvanta, Helder André, Massimo Dal Monte
Publikováno v:
Cells, Vol 10, Iss 1, p 177 (2021)
During retinal development, a physiologic hypoxia stimulates endothelial cell proliferation. The hypoxic milieu warrants retina vascularization and promotes the activation of several mechanisms aimed to ensure homeostasis and energy balance of both e
Externí odkaz:
https://doaj.org/article/791ce60accb944139b0ca35f37a54c6a
Autor:
Mattia Cantarini, Dario Rusciano, Rosario Amato, Alessio Canovai, Maurizio Cammalleri, Massimo Dal Monte, Cristina Minnelli, Emiliano Laudadio, Giovanna Mobbili, Giorgia Giorgini, Roberta Galeazzi
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 3
Pages: 2863
Volume 24
Issue 3
Pages: 2863
Glaucoma, a major ocular neuropathy originating from a progressive degeneration of retinal ganglion cells, is often associated with increased intraocular pressure (IOP). Daily IOP fluctuations are physiologically influenced by the antioxidant and sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e50ae98d716539f7bd684018cfebabd6
https://doi.org/10.3390/ijms24032863
https://doi.org/10.3390/ijms24032863
Autor:
Roberta Corsaro, Paola Bagnoli, Alberto Melecchi, Dario Rusciano, Rosario Amato, Alessio Canovai, Salvatore Pezzino, Maurizio Cammalleri, Massimo Dal Monte
Publikováno v:
Biomedicines
Volume 9
Issue 9
Biomedicines, Vol 9, Iss 1177, p 1177 (2021)
Volume 9
Issue 9
Biomedicines, Vol 9, Iss 1177, p 1177 (2021)
Light-induced retinal damage (LD) is characterized by the accumulation of reactive oxygen species leading to oxidative stress and photoreceptor cell death. The use of natural antioxidants has emerged as promising approach for the prevention of LD. Am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e881dc564dd6ebef3f3ef81e6304ccf