Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Alessio Balzerano"'
Autor:
Elena Paccosi, Giulia Artemi, Silvia Filippi, Alessio Balzerano, Federico Costanzo, Valentina Laghezza-Masci, Silvia Proietti, Luca Proietti-De-Santis
Publikováno v:
European Journal of Cell Biology, Vol 102, Iss 2, Pp 151325- (2023)
Mutations in CSA and CSB proteins cause Cockayne syndrome, a rare genetic neurodevelopment disorder. Alongside their demonstrated roles in DNA repair and transcription, these two proteins have recently been discovered to regulate cytokinesis, the fin
Externí odkaz:
https://doaj.org/article/0a31f918ce2c4ed88805ee4712c7026a
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2809 (2023)
The serine/threonine kinase Akt modulates the functions of numerous substrates, many of them being involved in cell proliferation and growth, metabolism, angiogenesis, resistance to hypoxia and migration. Akt is frequently deregulated in many types o
Externí odkaz:
https://doaj.org/article/af9aa9ee77204dfb9d7b023dfbeb7e05
Autor:
Elena Paccosi, Michele Costantino, Alessio Balzerano, Silvia Filippi, Stefano Brancorsini, Luca Proietti-De-Santis
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 10070 (2021)
Neuroblastoma, the most common extra-cranial solid tumor of early childhood, is one of the major therapeutic challenges in child oncology: it is highly heterogenic at a genetic, biological, and clinical level. The high-risk cases have one of the leas
Externí odkaz:
https://doaj.org/article/4022fd266270425389d845ef20a28a91
Autor:
Manuela Caputo, Alessio Balzerano, Ivan Arisi, Mara D'Onofrio, Rossella Brandi, Silvia Bongiorni, Stefano Brancorsini, Mattia Frontini, Luca Proietti-De-Santis
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0172399 (2017)
The DNA repair protein Cockayne syndrome group B (CSB) has been recently identified as a promising anticancer target. Suppression, by antisense technology, of this protein causes devastating effects on tumor cells viability, through a massive inducti
Externí odkaz:
https://doaj.org/article/5ada6a63f88243899d7d00ad3620186f
Publikováno v:
Biological trace element researchReferences.
Exposure to heavy metals represents one of the most important risk factors for the health of incinerator workers. Indeed, heavy metals can determine increased generation of reactive oxygen species (ROS). In this work, we introduced the use of transcr
Publikováno v:
Cytogenetic and Genome Research. 161:362-371
The goal in personalized therapeutic approaches for cancer medicine is to identify specific mutations with prognostic and therapeutic value in order to tailor the therapy for the single patient. The most powerful obstacle for personalized medicine ar
Autor:
Silvia Filippi, Elena Paccosi, Alessio Balzerano, Margherita Ferretti, Giulia Poli, Juri Taborri, Stefano Brancorsini, Luca Proietti-De-Santis
Publikováno v:
Cancers; Volume 14; Issue 7; Pages: 1687
Breast cancer (BC) is the most common cancer with the highest frequency of death among women. BC is highly heterogenic at the genetic, biological, and clinical level. Despite the significant improvements in diagnosis and treatments of BC, the high ra
Autor:
Silvia Filippi, Elena Paccosi, Alessio Balzerano, Stefano Brancorsini, Michele Costantino, Luca Proietti-De-Santis
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10070, p 10070 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 18
International Journal of Molecular Sciences
Volume 22
Issue 18
Neuroblastoma, the most common extra-cranial solid tumor of early childhood, is one of the major therapeutic challenges in child oncology: it is highly heterogenic at a genetic, biological, and clinical level. The high-risk cases have one of the leas
Autor:
Federico Costanzo, Michele Costantino, Laura Monteonofrio, Stefano Brancorsini, Giorgio Prantera, Luca Proietti-De-Santis, Alessio Balzerano, Silvia Soddu, Elena Paccosi, Jean-Marc Egly
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (48), pp.30498-30508. ⟨10.1073/pnas.2006543117⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2020, 117 (48), pp.30498-30508. ⟨10.1073/pnas.2006543117⟩
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (48), pp.30498-30508. ⟨10.1073/pnas.2006543117⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2020, 117 (48), pp.30498-30508. ⟨10.1073/pnas.2006543117⟩
International audience; Cytokinesis is monitored by a molecular machinery that promotes the degradation of the intercellular bridge, a transient protein structure connecting the two daughter cells. Here, we found that CSA and CSB, primarily defined a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce326e3a2f8437cb2d67cd14870676eb
http://hdl.handle.net/11391/1517469
http://hdl.handle.net/11391/1517469
Publikováno v:
Trends in cancer. 4(3)
The DNA repair protein Cockayne syndrome group B (CSB) is frequently found overexpressed in cancer cells. High CSB levels favor tumor cell proliferation whilst inhibiting apoptosis. Conversely, the suppression of CSB has significant anticancer effect