Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Alessio, Tovaglieri"'
Autor:
Thomas D. Lewin, Blandine Avignon, Alessio Tovaglieri, Lauriane Cabon, Nikolche Gjorevski, Lucy G. Hutchinson
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Cancer immunotherapy often involves the use of engineered molecules to selectively bind and activate T cells located within tumour tissue. Fundamental to the success of such treatments is the presence or recruitment of T cells localised within the tu
Externí odkaz:
https://doaj.org/article/fd3e59da22e0471e9e57da377981c377
Autor:
Alexandra Sontheimer-Phelps, David B. Chou, Alessio Tovaglieri, Thomas C. Ferrante, Taylor Duckworth, Cicely Fadel, Viktoras Frismantas, Arlene D. Sutherland, Sasan Jalili-Firoozinezhad, Magdalena Kasendra, Eric Stas, James C. Weaver, Camilla A. Richmond, Oren Levy, Rachelle Prantil-Baun, David T. Breault, Donald E. Ingber
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 3, Pp 507-526 (2020)
Background & Aims: The mucus layer in the human colon protects against commensal bacteria and pathogens, and defects in its unique bilayered structure contribute to intestinal disorders, such as ulcerative colitis. However, our understanding of colon
Externí odkaz:
https://doaj.org/article/554b633ff25042a892b30b69e190d4cd
Autor:
Alessio Tovaglieri, Alexandra Sontheimer-Phelps, Annelies Geirnaert, Rachelle Prantil-Baun, Diogo M. Camacho, David B. Chou, Sasan Jalili-Firoozinezhad, Tomás de Wouters, Magdalena Kasendra, Michael Super, Mark J. Cartwright, Camilla A. Richmond, David T. Breault, Christophe Lacroix, Donald E. Ingber
Publikováno v:
Microbiome, Vol 7, Iss 1, Pp 1-21 (2019)
Abstract Background Species-specific differences in tolerance to infection are exemplified by the high susceptibility of humans to enterohemorrhagic Escherichia coli (EHEC) infection, whereas mice are relatively resistant to this pathogen. This intri
Externí odkaz:
https://doaj.org/article/76b721f3cb93444bb33fc22d0b887943
Autor:
Camilla A. Richmond, Hannah Rickner, Manasvi S. Shah, Tracy Ediger, Luke Deary, Fanny Zhou, Alessio Tovaglieri, Diana L. Carlone, David T. Breault
Publikováno v:
Stem Cell Reports, Vol 10, Iss 1, Pp 17-26 (2018)
Summary: The intestinal epithelium serves as an essential barrier to the outside world and is maintained by functionally distinct populations of rapidly cycling intestinal stem cells (CBC ISCs) and slowly cycling, reserve ISCs (r-ISCs). Because disru
Externí odkaz:
https://doaj.org/article/0cb59d8f737a4c27b185dba443005144
Autor:
Amir Bein, Woojung Shin, Sasan Jalili-Firoozinezhad, Min Hee Park, Alexandra Sontheimer-Phelps, Alessio Tovaglieri, Angeliki Chalkiadaki, Hyun Jung Kim, Donald E. Ingber
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 4, Pp 659-668 (2018)
Microfluidic organ-on-a-chip models of human intestine have been developed and used to study intestinal physiology and pathophysiology. In this article, we review this field and describe how microfluidic Intestine Chips offer new capabilities not pos
Externí odkaz:
https://doaj.org/article/1649e018d954403a9bd7246603660a8c
Autor:
Camilla A. Richmond, Manasvi S. Shah, Luke T. Deary, Danny C. Trotier, Horatio Thomas, Dana M. Ambruzs, Lijie Jiang, Bristol B. Whiles, Hannah D. Rickner, Robert K. Montgomery, Alessio Tovaglieri, Diana L. Carlone, David T. Breault
Publikováno v:
Cell Reports, Vol 13, Iss 11, Pp 2403-2411 (2015)
The cellular and molecular mechanisms underlying adaptive changes to physiological stress within the intestinal epithelium remain poorly understood. Here, we show that PTEN, a negative regulator of the PI3K→AKT→mTORC1-signaling pathway, is an imp
Externí odkaz:
https://doaj.org/article/cddef076518c4b6d880192dc6ebfe2f1
Autor:
Jesse Lyons, Phaedra C Ghazi, Alina Starchenko, Alessio Tovaglieri, Katherine R Baldwin, Emily J Poulin, Jessica J Gierut, Casie Genetti, Vijay Yajnik, David T Breault, Douglas A Lauffenburger, Kevin M Haigis
Publikováno v:
PLoS Biology, Vol 16, Iss 3, p e2002417 (2018)
Inflammatory bowel disease (IBD) is a chronic condition driven by loss of homeostasis between the mucosal immune system, the commensal gut microbiota, and the intestinal epithelium. Our goal is to understand how these components of the intestinal eco
Externí odkaz:
https://doaj.org/article/47ef114201964675b32fd68e61204548
Publikováno v:
Stem Cell Reports, Vol 5, Iss 5, Pp 673-681 (2015)
Lgr5-expressing intestinal stem cells (ISCs) renew the adult gut epithelium by producing mature villus cells (VCs); the transcriptional basis for ISC functions remains unclear. RNA sequencing analysis identified transcripts modulated during different
Externí odkaz:
https://doaj.org/article/f3fa9b1b10b34cd18add73b4dfd9832c
Autor:
Thomas C. Ferrante, Viktoras Frismantas, Donald E. Ingber, David T. Breault, Sasan Jalili-Firoozinezhad, David B. Chou, Cicely Fadel, Magdalena Kasendra, James C. Weaver, Eric Stas, Rachelle Prantil-Baun, Oren Levy, Camilla A. Richmond, Alexandra Sontheimer-Phelps, Arlene D. Sutherland, Taylor Duckworth, Alessio Tovaglieri
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 3, Pp 507-526 (2020)
Background & Aims: The mucus layer in the human colon protects against commensal bacteria and pathogens, and defects in its unique bilayered structure contribute to intestinal disorders, such as ulcerative colitis. However, our understanding of colon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e9771646a41f9111333a9cd11e0ed2d
http://www.sciencedirect.com/science/article/pii/S2352345X19301638
http://www.sciencedirect.com/science/article/pii/S2352345X19301638
Autor:
Thomas D, Lewin, Blandine, Avignon, Alessio, Tovaglieri, Lauriane, Cabon, Nikolche, Gjorevski, Lucy G, Hutchinson
Publikováno v:
Frontiers in pharmacology. 13
Cancer immunotherapy often involves the use of engineered molecules to selectively bind and activate T cells located within tumour tissue. Fundamental to the success of such treatments is the presence or recruitment of T cells localised within the tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::494c6e725ea0d4522920602b596abf4d
https://pubmed.ncbi.nlm.nih.gov/35586042
https://pubmed.ncbi.nlm.nih.gov/35586042